Monday, 22 Jan 2018

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Ibuprofen’s Anti-androgenic Effect May Result in Hypogonadism in Males

PNAS reports use of ibuprofen by males may result in antiandrogen effects that may contribute to adult male reproductive problems.

40% of Arthritis Patients Fail to Receive Exercise Guidance

The latest issue of CDC’s MMWR reports that exercise counseling among arthritis patients increased from 52% to 61% (2002 to 2014); hence ~40% do not receive health care provider counseling, suggesting the need for provider education and training in exercise counseling, and improved electronic medical record reminders.

Increasing Adverse Events Seen with Higher Disease Activity in Early RA

Researchers in the NEO-RACo Study Group studied adverse events (AEs) in relation to disease activity in patients with early rheumatoid arthritis (RA).

Small Joint Surgeries Drop Among RA Patients

The rate of small - but not large - joint surgery has dropped among patients with rheumatoid arthritis since 1995, a retrospective review of orthopedic surgeries found. By 2015, less than 1% of patients per year underwent small joint surgery, reported Ashima Makol, MD, of the Mayo Clinic in Rochester, Minnesota, and colleagues in Arthritis Care & Research. 

2018 Predictions for Rheumatology

MedPage Today Editors surveyed a few rheumatologists for their major news predictions in 2018. Read on for predictions regarding drug pricing, biosimilars, autoimmunity and checkpoint inhibitors, and thrombotic events and JAK inhibition.

Calcium and Vitamin D Supplements Do Not Reduce Hip Fractures

Recent JAMA study shows metanalysis of 33 clinical trials and 51,145 participants, showed that calcium, vitamin D, or both affords no decreased risk of hip fractures compared with placebo or no treatment and therefore questions their routine widespread use in the elderly.. 

The RheumNow Week in Review - 5 January 2018

Dr Jack Cush reviews the news and journal articles from the past week on RheumNow.com.  

Stem Cell Transplant Succeeds in Scleroderma

Myeloablative autologous stem cell transplantation was significantly more effective than 12 months of cyclophosphamide among patients with severe scleroderma, an open-label multicenter study found.

Malcolm Gladwell Weighs in on Humanizing Doctors Through Aesthetic Interests

Malcolm Gladwell (along with coauthor David Epstein) is well known for his national bestsellers The Tipping Point, Blink, and Out¬liers; all addressing the psychosociologic side of human behaviors and trends. In this issue of Ophthalmology, he describes the "Termin Effect" and how to make better doctors, by sending medical students art school.

Sorting Out the Complexities of Autoimmunity with Immune Checkpoint Inhibitor Therapy

An editorial and systematic review of complications seen when checkpoint inhibitor (CPI) therapies are given to patients with immune mediated inflammatory disorders (IMIDs) and cancer shows that nearly 75% manifest autoimmune and inflammatory immune-related adverse events (irAEs).

Community Screening for Fracture Risk in Older Women is Effective and Feasible

A UK Study published in Lancet shows that community-based screening programme for fracture risk in older women is feasible, and may reduce hip fractures. 

Older women, age 70-85 yrs, were identified and participated in the trial and were assessed using the Fracture Risk Assessment Tool (FRAX) with usual management. 12 483 were enrolled and 6233 women randomly assigned to the screening group.

Despite Increasing Metric Use, They Are Not Widespread in Rheumatoid Care

The Journal of Rheumatology has published a nationwide survey of US rheumatologists and shown that despite trends for increasing metric assessments, nearly half of rheumatoid arthritis (RA) patients are not routinely assessed with a disease activity metric and the evidence they use these in a treat-to-target (T2T) practice is lacking.