Wednesday, 21 Nov 2018

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Factors That Contribute to Uveitis in SpA

We know that uveitis is an extra-articular manifestation of SpA but what remains unclear is if there are any factors that may play a role in the development of uveitis. One group sought to understand these issues.

ACR 2018 - Day 1 Report

RheumNow is in Chicago covering the ACR annual meeting. Here are the highlights from Sunday (day one). Be sure to check our complete coverage, including articles, video reports and tweets, at

Gout and the Social Determinants of Health

During a fascinating gout session on October 21, Hyon Choi presented an important paper (abstract 874) which used data from the Health Professionals Follow-up Study to try to understand the rapid increase in the incidence of gout in recent decades.

Because It's Rare Doesn’t Mean It Doesn’t Exist: A Tribute to Relapsing Polychondritis

During medical training, we were taught about rare diseases that are unlikely to be encountered, but there is a reason why our professors even mention these diseases. It is not just for our board exams; the lectures are for us to recognize the features of the disease when the rare patient comes across our exam table.

High Dose Flu Vaccine for Patients Younger Than 65?

We are diving head first into flu season and we need to prepare ourselves. Last year we now know that 80,000 Americans died from influenza. I was happy to see the abstract presented in today’s plenary session by Colmegna et al about efficacy of high dose influenza vaccine in patients with rheumatoid arthritis (#837). This study was a randomized, modified double-blind, active-controlled trial carried out in adults with RA.

The Great Debate: Plaquenil - Choosing Safety over Efficacy?

I am usually thrilled to offer Plaquenil as one of the safer  therapy options to my patients with lupus and other autoimmune conditions. Unfortunately, on many occasions, once we go into detailed discussion of the potential side effects with the patient,  the issue of hydroxychloroquine eye toxicity casts a cloud over  overall optimistic view of Plaquenil.

ICI-Induced Inflammatory Arthritis and Shared Epitope Alleles

Immune checkpoint inhibitors (ICI) have changed the hematology/oncology world. However, their AEs from a rheumatologic standpoint are still being evaluated and at this time, genetic risk factors for inflammatory arthritis due to ICI are not well understood. Dr. Cappelli et al evaluated a possible connection with HLA typing at their institution.

Walking the Tightrope of Treat to Target in Psoriatic Arthritis

In the last few years, new studies have been published examining if early intervention and tight control (TC) of psoriatic arthritis (PsA) disease activity will have the same beneficial outcomes as it does for rheumatoid arthritis (RA).  

Nurse Led Gout Management Highly Effective

UK researchers have shown that nurse-led gout management, using a treat-to-target urate-lowering strategy, is efficacious and cost-effective compared with usual physicain care. The results are published in the recent Lancet edition.

Worldwide, gout management is suboptimal. In the UK only 40% of gout patients receive urate-lowering therapy, and fewer ever achieve a target serum urate (< 6mg/d) concentration.

RheumNow Week in Review – ACR Preview Edition (10.19.18)

Dr. Jack Cush summarizes the news and reports from RheumNow.Com this past week and previews RheumNow activities at the upcoming ACR 2018 meeting in Chicago.

It's the Genes, Not the Diet that Raises Urate

Researchers from New Zealand find that in contrast with genetic contributions, diet explains very little variation in serum urate levels in the general population.

NEJM Debate on Medical Marijuana for Chronic Pain

This week’s NEJM features a case discussion and debate over whether medical marijuana should be used to treat chronic pain. The debate focuses on a 31-year-old woman with long-standing complex regional pain syndrome in her leg and foot. CRPS followed a sports related hairline fracture in the right fibula. Her pain has been intractable since.