Friday, 17 Aug 2018

You are here

Biosimilar Data at #EULAR2018

Biosimilars are here, and more are being registered all the time, so I was really interested in the biosimilar data at the meeting.

Abstract THU0222 reported data on 143 patients from a single clinic, ~50% had RA, and multi-switching between the etanercept originator and the biosimilar had no effect on retention of etanercept. In fact there may have even been a small protective effect of multi-switching on etanercept retention. Now it’s a single centre and its observational data so must be treated with a degree of caution but it’s an interesting result.

Another study from a large UK centre looked at the rate of flare after changing from the originator to the biosimilar and for etanercept found 4 out of 63 with RA flares after the change and 2 of 19 with SpA and 2 of 19 with PsA. For the infliximab biosimilar the flare rates was 2-4% across indications. Their conclusions were that the rate of flares was low and this supported single switch (THU0204)

Data from the TURKBIO registry on 614 patients showed that Remsima the infliximab biosimilar had better retention rates than Remicade over 5 years (THU 0218). There is also RABBIT registry data using Kaplan-Meier estimates showed that patients who were bionaive and were commenced on both the originator and biosimilar etanercept. The SB4 biosimilar (n = 250) was stopped around half the rate (14%) and the etanercept originator (n = 317) (THU0192).

So there seems to be an enlarging amount of data that is reassuring around switching patients to biosimilars and drug survival on biosimilars. But it is important to remember that registry and observational data has limitations so care has to be taken to put excessive weight on these types of results.

Add new comment

More Like This

Success of Stopping Depends on the Biologic

The type of biologic disease-modifying anti-rheumatic drug (DMARD) being used and remission duration were important factors predicting whether remission was maintained among patients with rheumatoid arthritis after cessation of the biologic, a Japanese study found.

IL-1 Suppression May Improve Dilated Cardiomyopathy

 

Interleukin-1 (IL-1) suppression helped reverse symptoms of dilated cardiomyopathy (DCM) for one patient in a case study that may implicate inflammation in the development of the condition.

Defining Refractory RA by Biologic Use

A study from the  British Society for Rheumatology Biologics Register (BSRBR) has shown that biologic refractory disease is seen in at least 6% of patients who have ever received a biologic DMARD (bDMARDs).

IL-23 Inhibitor Fails in Ankylosing Spondylitis

A study of the IL-23 risankizumab in active ankylosing spondylitis (AS) patients failed to show efficacy and did not meet primary efficacy endpoints in a 6-month trial.

Five Barriers to Biosimilar Adoption in the US

A recent Deloitte analysis of the biosimilar market in the USA suggests there are defined obstacles to biosimilar use that must be dealt with, especially as the current administration is seeking to lower drug prices and reduce out-of-pocket costs for US consumers.