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Two recent reports have shown that gout is associated with a lower risk of dementia and Alzheimers disease. The proposed mechanism involves the antioxidant effect or uric acid and its neuroprotective effects. Lu et al studied a large UK population and found a 24-29% reduction in Alzhemers risk in gout patients compared to 5 matched population controls (http://url.ie/z0o2). Hong and coworkers studied claims data in Taiwan and also noted a 24% reduction in both vascular and nonvascular dementia. It is unclear if patients treated with urate lowering therapy will lose this potential advantage.