Friday, 21 Sep 2018

You are here

HERO Trial - Hydroxychloroquine Fails in Hand Osteoarthritis

UK researchers have treated 248 patients with moderate to severe hand pain and radiographic osteoarthritis (OA) and demonstrated no benefit after 12 months of hydroxychloroquine (HCQ), according to a recent article in Annals of Internal Medicine.

A randomized, double-blind, placebo-controlled clinical trial from 13 centers in England enrolled adults with hand OA and pain ≥4 (0-10 VAS) with evidence of radiographic hand osteoarthritis. The supposition was that control of inflammation and low grade synovitis would forestall the progression of OA. 

At 6 months (the primary endpoint), the mean hand pain was similar between groups (5.49 PBO vs 5.66 HCQ). No other significant treatment differences were found at 3, 6, or 12 months for any secondary outcomes.

Whlle X-rays and grayscale ultrasonography were done at baseline, these were not assessed at the endpoints. 

HCQ is one of many agents to have been tested, and failed at altering the course or symptom severity of hand OA.

Disclosures: 
The author has no conflicts of interest to disclose related to this subject

Add new comment

More Like This

Maastricht Study Links Dairy Intake to Osteoarthritis

The Maastricht study explored the potential association between dairy consumption and knee osteoarthritis (OA), and found that higher intake of full-fat dairy and Dutch cheese - but not milk - was significantly associated with the lower risk of knee OA.

Osteoarthritis and the Risk of Mortality

Osteoarthritis (OA) affects 27 million Americans but its affect on mortality is uncertain. A recent study shows that while self-reported OA does not increase mortality, radiographic OA of the knee (RKOA) is associated with higher mortality related to CVD, diabetes and renal disease.

2018 EULAR Recommendations for Hand Osteoarthritis Care

The uropean League Against Rheumatism (EULAR) has previously put forth recommendations for management of hand osteoarthritis (OA) in 2007. But since then, advances and further evidence have emerged.

An international panel of 19 physicians, healthcare professionals and patients from 10 European countries formulated five overarching principles and 10 new recommendations after a systematic literature review was performed.

Persistent Osteoporosis Drug Use Pays Off

Among elderly female Medicare patients, persistent use of osteoporosis medications was associated with reduced risk of fracture and significantly lower total health care costs.

Osteoporosis International reports the results of research examining records of 294,369 women >65 years old, on Medicare and taking osteoporosis medicines for the first time at some point between 2009 and 2011. (Citation Source: bit.ly/2vALm98) 

Fractures Augment 10 Year Mortality Risks

This nationwide study of adults (50+ yrs) from Denmark has shown that following a fragility fracture, the 10-years mortality risk was increased, especially in the first year following the fracture.