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UK researchers have treated 248 patients with moderate to severe hand pain and radiographic osteoarthritis (OA) and demonstrated no benefit after 12 months of hydroxychloroquine (HCQ), according to a recent article in Annals of Internal Medicine.
A randomized, double-blind, placebo-controlled clinical trial from 13 centers in England enrolled adults with hand OA and pain ≥4 (0-10 VAS) with evidence of radiographic hand osteoarthritis. The supposition was that control of inflammation and low grade synovitis would forestall the progression of OA.
At 6 months (the primary endpoint), the mean hand pain was similar between groups (5.49 PBO vs 5.66 HCQ). No other significant treatment differences were found at 3, 6, or 12 months for any secondary outcomes.
Whlle X-rays and grayscale ultrasonography were done at baseline, these were not assessed at the endpoints.
HCQ is one of many agents to have been tested, and failed at altering the course or symptom severity of hand OA.