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PNAS reports use of ibuprofen by males may result in antiandrogen effects that may contribute to adult male reproductive problems.
Young men exposed to ibuprofen show changes of “compensated hypogonadism," a condition usually seen among elderly men and associated with reproductive and physical disorders. In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased.
Researchers used a combination of a randomized, controlled clinical trial and ex vivo and in vitro approaches, and found a univocal depression of testicular function, including testosterone production, after use of over-the-counter ibuprofen.
Also, ibuprofen use results in selective transcriptional repression of endocrine cells in the human testis. This repression results in the elevation of the stimulatory pituitary hormones, resulting in a state of compensated hypogonadism.
Thes findings show ibuprofen alters the endocrine system via selective transcriptional repression in the human testes, thereby inducing compensated hypogonadism.