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IL-23 Outduels IL-17 Inhibition in Psoriasis

Johnson & Johnson has announced the preliminary results of its phase 3 ECLIPSE study; a head-to-head trial wherein guselkumab (Tremfya; an IL-23 inhibitor) was compared to secukinumab (Cosentyx; an IL-17 inhibitor) in adults with moderate to severe plaque psoriasis.

This study of 1,048 patients showed guselkumab to be significantly better than secukinumab. Guselkumab treated patients demonstrated PASI90 scores of 84.5% vs. 70% for those on secukinumab at week 48 (p<0.001).

The time to response, however, was similar between the two drugs.

According to Reuters, Tremfya, first approved in July 2017 as a plaque psoriasis treatment in the U.S., is also being tested as a treatment for psoriatic arthritis and Crohn’s disease.  Cosentyx, which has been approved in the U.S. for plaque psoriasis, scalp psoriasis and psoriatic arthritis, is a key sales driver which raked in $2.1 billion for the drugmaker in 2017.

Disclosures: 
The author has received compensation as an advisor or consultant on this subject

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