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Intracranial Hemorrhage with Combined NSAID and Antidepressant Use

The British Medical Journal reports that the combined use of NSAIDs and anti-depressants were associate with higher rates of intracranial bleeding within 30 days of initiation (Citation source http://buff.ly/1gF3uEJ). This Korean study examined a claims database of over 4 million persons and showed an increased rate of bleeds (hazard ratio 1.6, 95% confidence interval 1.32 to 1.85), irrespective of which anti-depressant was used.

Disclosures: 
The author has no conflicts of interest to disclose related to this subject

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