Friday, 20 Sep 2019

You are here

It's the Genes, Not the Diet that Raises Urate

Researchers from New Zealand find that in contrast with genetic contributions, diet explains very little variation in serum urate levels in the general population.

A total of 16,760 adults of European ancestry from the US were included in analyses. They were without kidney disease or gout, and not taking urate lowering or diuretic drugs.  All were assessed for serum urate, dietary survey data, potential confounders (sex, age, body mass index, average daily calorie intake, years of education, exercise levels, smoking status, and menopausal status), and genome wide genotypes.

The main outcome measures were average serum urate levels and variance in serum urate levels. 

They found that seven foods were associated with raised serum urate levels: beer, liquor, wine, potato, poultry, soft drinks, and meat (beef, pork, or lamb).

Eight foods were associated with reduced serum urate levels: eggs, peanuts, cold cereal, skim milk, cheese, brown bread, margarine, and non-citrus fruits.

Three diet scores, constructed on the basis of healthy diet guidelines, were inversely associated with serum urate levels.

Overall, diet explained ≤0.3% of variance in serum urate levels.

By comparison, 23.9% of variance in serum urate levels was explained by common, genome wide single nucleotide variations.

 

Disclosures: 
The author has no conflicts of interest to disclose related to this subject

Add new comment

More Like This

Higher Rates of Venous Thromboembolism in Gout

A Canadian administrative claims analysis has shown that gout-associated inflammation increases the risk of venous thromboembolism (VTE), deep vein thrombosis (DVT), and pulmonary embolism (PE) before and after the diagnosis of gout.

Modifiable Risk Factors for Hyperuricemia

Choi and colleagues have shown that four modifiable risk factors (BMI, the DASH diet, alcohol use, and diuretic use) could individually account for a notable proportion of observed hyperuricemia. 

Researchers examine modifiable risk factors for hyperuricemia and how this could be prevented through risk factor modification in the general population.

Opioids Overused in Acute Gout

Opioids were commonly given to patients as a treatment for acute gout attacks, despite the availability of other effective and appropriate therapies, a retrospective study found.

Allopurinol Fails to Curtail Hypertension

Editor's note: July 1 - 5, RheumNow is running the best of the EULAR 2019 meeting. A novel trial presented at EULAR 2019 last week assessed whether the use of urate-lowering therapy (ULT) would control hypertension in those at risk; however, results of this trial were largely negative.

Hypertension is one of the many comorbidities that plagues gout patients.

Allopurinol Fails to Curtail Hypertension

A novel trial presented at EULAR 2019 last week assessed whether the use of urate-lowering therapy (ULT) would control hypertension in those at risk; however, results of this trial were largely negative.

Hypertension is one of the many comorbidities that plagues gout patients.