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An observational case-control study has shown that psoriasis is associated with an increased prevalence of nonalcoholic fatty liver disease (NAFLD).
A single center, outpatient dermatology clinic studied 151 patients with psoriasis and 51 control subjects with ultrasonography to diagnose NAFLD.
They found that NAFLD was 3-fold more likey in patients with psoriasis (21.2% vs. 7.8%, p<0.04). However, the association with psoriasis was not significant after controlling for age, sex, and body mass index (BMI) (odds ratio: 2.63, 95% confidence interval [CI]: 0.51-13.6; p=0.25).
Psoriasis patients with NAFLD were more likely to be obese (BMI: 34.9 vs. 27.2, 95% CI: 32.4-37.5 vs. 25.9-28.5; p<0.01) and have select components of metabolic syndrome, including hyperglycemia and hyperlipidemia.
Psoriasis patients are known to have more comorbidities, obesity and the metabolic syndrome. NAFLD can be added to the potential risks associated with psoriatic disease.