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The RheumNow Week in Review – 13 January 2017

Dr. Jack Cush reviews highlights from this past week on RheumNow.com:

  1. ARTIS RA registry shows those initiating a TNFi within 5 yrs of onset double their odds of returning to work in 3 yrs https://t.co/WytSlSYRj1
  2. ARTIS & DANBIO registries: 8703 SpA (AS, PsA) patients treated with TNFI: they do NOT have an increase risk of cancer overall; nor the 6 most common types CA http://buff.ly/2icvD9O
  3. Hepatosplenic T cell lymphoma: review shows this to be a very rare event with TNFi; but is more common in IBD pts (younger), receiving thiopurines. http://buff.ly/2jn7Bqm
  4. Biosimilar Inflectra priced at only a 15% discount; CMS issues payment and claims processing information https://t.co/lCwn198PAN
  5. There is no interaction between low dose weekly MTX and NSAIDs, PCNs or PPIs. https://t.co/h4JeLoSbEg
  6. FDA reviewing a new drug application (NDA) for the new combo drug: allopurinol + lesinurad (Ironwood Pharm) to Rx hyperuricemia and uncontrolled gout https://t.co/e95R8TlXuv
  7. Meta-analysis of 1069 knee OA patients- intraarticular Platelet Rich Plasma (vs HA, NS) shows significantly better WOMAC pain/function scores. @12mo https://t.co/LBJt2SbZXO,
  8. Chronic PPI use associated with 74% more C difficile infections & 2.5-fold increased risk of recurrent C difficile with chronic PPI https://t.co/W1mLbPEPYP
  9. 13% of US African Americans have diabetes; but AA are seldom included in diabetes clinical trials. Whatsupwiththat? https://t.co/GYgXnAcyzb
  10. Total knee vs hemiarthroplasty show equal outcomes;more complications with bilateral total knee replacements (pt selection is critical to the success of hemiarthroplasty) https://t.co/D8OXH8VnTA
  11. 94 pts with MTX pancytopenia in elderly; 24% mortality; risk factors include age>65, sepsis + hypoalbuminemia https://t.co/7p99v9bt3g
  12. Multiple Comorbidity Risks with Giant Cell Arteritis
  13. Do Exercise ‘Weekend Warriors’ Lower Their Risk of Death? 
  14. The IL-6 Wars 
  15. DMARDs Under Study for Secondary Prevention of Cardiovascular Events

 

Disclosures: 
The author has no conflicts of interest to disclose related to this subject
The author has received compensation as an advisor or consultant on this subject

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