Tuesday, 18 Dec 2018

You are here

The RheumNow Week in Review - 15 December 2017

Dr. Jack Cush reviews the news from the past week on RheumNow.com. Subscribe to the podcast on iTunes and SoundCloud.com. 

  1. NICE and NHS reject the approval of Tocilizumab for use in GCA citing cost concerns https://t.co/TZMmnj91sp https://t.co/aQMFLKVCYo
  2. Another TNFi biosimilar FDA approved yesterday! This time its Pfizers Ixifi (infliximab-qbtx) becomes the 3rd remicade biosimilar (Inflectra, Renflexis) and the 6th TNFi biosimilar (in addition to Erelzi, Amjevita, Cyltezo) to be FDA approved in 20 mos. https://buff.ly/2C2fWcl
  3. 240 pts with FUO or inflammation unknown origin (IUO) studied w/ FDG-PET = helpful in Dx of >50% of pts. 190 pts (79.2%) were dx by FDG-PET (Still’s, Lg vessel vasculitis, PMR, IgG4 most common) FDG-PET/CT most helpful with age >50, CRP >30 mg/L & no fever https://buff.ly/2nQcPSK
  4. Small pilot, controlled, delayed Rx trial of 20 PM/DM pts showed at 3 mos,  50% of Abatacept, but only 11% of control/delayed Rx pts responded to therapy.  At 6 mos, with all on ABA, 8/19 responded.  ABA has potential and merits further study in PM/DM  https://buff.ly/2B4ezgg
  5. Data presented at American Society of Hematology mtg shows that Abatacept treatment decreases GVHD 32% to 2%  in patients receiving hematopoietic stem cell transplants Rx for advanced cancer & other blood disorders https://buff.ly/2kTlmDe
  6. C4d may be useful in monitoring SLE. C4d PPV 68% for high Dz activty, correlates w/ SLEDAI w/ higer Dz activity & C4d w/ dsDNA 5 fold better ability to predict lupus nephritis. https://t.co/LpUuAaqUWl
  7. 611 Finnish DMARD NAIVE, Early RA pts (71% RF+) treated with DMARDs, Triple Rx - 68% and 75% achieve DAS28-3 remission at 3 mos and 6 mos respectively. Hence higher response rates with earlier Dx and Rx! https://t.co/iWBs5vhxc7
  8. Similarities were found between Feltys syndrome and LGL leukemia - in both 40% have somatic STAT3 mutations, expansion of CD8+ T cells, same cytokine profile and STAT3 activation  https://buff.ly/2nOLZdB
  9. Febuxostat Works in Early Gout But Fails to Protect from Xray Damage
  10. FDA Approves Mepolizumab for Churg-Strauss (EGPA)
  11. Offspring of RA Women Have Higher Risk of RA and Other Diseases 

 

 

Disclosures: 
The author has received compensation as an advisor or consultant on this subject

Add new comment

More Like This

RheumNow Podcast – Vasculitis and Strange Bedfellows (12.14.18)

Dr. Jack Cush reviews the news from the past week on RheumNow.com. 

RheumNow Podcast – Can RA Be Prevented (12.7.18)

Dr. Jack Cush reviews the news and new journal articles from the past week on RheumNow.com:

Chronic Kidney Disease Increasing in the U.S.A.

JAMA has published the Global Burden of Disease (GBD) study showing that that, from 2002 to 2016, the US burden of chronic kidney disease (CKD) increased, with some states exhibiting more than twice the burden as others. The increase in burden was associated with increased metabolic and dietary risk exposure that manifested in increased probability of death due to diabetic CKD, especially for those between 20 to 55 years.  

RheumNow Podcast – To Needle or Not to Needle (11.30.18)

Dr. Jack Cush updates the news and reports from the past week at RheumNow.com:

Physical Activity Guidelines for Americans

The data are clear and disappointing: despite the well-known health benefits, four out of five US adults are not active physically.  JAMA has published the new US Physical Activity Guidelines for Americans, so that health professionals and policy makers can promote lifestyle changes and awareness of the the health benefits of physical activity.