Friday, 13 Jul 2018

You are here

The RheumNow Week in Review - Nonadherence and Astronomic Costs (5.11.18)

Dr. Jack Cush reviews highlights, news and journal articles from the past week on RheumNow.com.

  1. Australian RCT treated Trochanteric bursitis (glueal tendinopathy) w/ either education + exercise (EDX), steroid injx or "wait & see". EDX wins w/ better pain and global scores at wk 8 and better global scores at wk 52 (still less pain) https://t.co/eNky3xc9fW https://t.co/v6U8HRfqe0
  2. In an animal model of induced large vessel vasculitis, in vivo Rx w/ tofacitinib reduced JAK2 & JAK 2 cytokine signaling and suppressed tissue-resident memory T cells and vasculitic pathology. https://t.co/7JIMbryFxo
  3. AbbVie Submits Biologics License Application to FDA for Risankizumab (IL-23 Mab) for Moderate to Severe Plaque Psoriasis https://t.co/4lq3xKc6T1
  4. FDA has approved 9 biosimilars in the USA> Zarxio, Inflectra, Erelzi, Amjevita, Renflexis, Cyltezo, Ixifi; Mvasi (Avastin), Ogivri (Herceptin). There are 5 more biosimilars (of either filgrastim or herceptin) in front of FDA w/ upcoming PDUFA dates https://t.co/jeQoGJmygF
  5. The FDA may be getting into the EHR business; FDA has requested $100 million in FY2019 for an EHR initiative to evaluate the safety of regulated products. THis would connect patient safety and outcomes directly to the FDA. https://t.co/DuNorLFKr4
  6. UK study of 1207 male ex-footballers & 4085 control pop. men shows knee osteoarthritis outcomes (knee pain, RKOA TKR) 2-3 times higher in male ex-footballers compared with men in the general population group https://t.co/FJQ34Dm84a
  7. Patients May Not Fill Your Prescription   
  8. Severity of Lupus Nephritis is Declining over Time  
  9. 60 Minutes Drills Acthar - A Financially Crippling Drug   
  10. "Not all symptoms merit a diagnosis or disease, some are just evidence of human imperfection" - J Cush, MD
  11. "I'm addicted to placebos. I'd give them up, but it wouldn't make any difference."  - Steven Wright

 

Disclosures: 
The author has received compensation as an advisor or consultant on this subject

Rheumatologists' Comments

Jack-I will re-try sending this. Your comment "Not all symptoms merit a diagnosis or disease, some are just evidence of human imperfection" - J Cush, MD- strikes a chord with me as I work 6 months a year in locums to keep my skills up. I see many people who have been labeled as inflammatory arthritis, SNRA, UCTD, etc dutifully treated with multiple DMARDs and biologics. Over time, their rheumatologists change but the EHR continues to represent a label as a diagnosis. Subsequent rheumatology providers choose to continue the treatments with dangerous and expensive meds without re-visiting the diagnosis. They take the easy way out and run the patient thru rather than re-invent the wheel or upset the patient who usually doesn't have a clue (especially if underprivileged). No critical thinking or intellectual honesty-just get 'em in and get 'em out and look good on paper (screen of EHR). Very worrisome and a real trap for those who are taking care of he EHR more than the patient. The treatment decisions seem permanent and are not re-evaluated over time for many patients in this uncertain diagnosis category. After FMS, SNRA is a vexing diagnostic label.-David

More Like This

The RheumNow Week in Review –Fateful Outcomes in Rheumatology (7.13.18)

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com.  Fateful outcomes in Rheumatology, what happens to Seronegatives, IL-23 fails, MRI progression, Not all inflammatory back pain becomes SpA:

The RheumNow Week in Review – Life Savers for Rheumatologists (6.29.18)

Dr. Jack Cush reviews selected news and journal reports from the past week on RheumNow.com.

The RheumNow Week in Review – EULAR18 Epilogue (6.22.18)

Dr. Jack Cush reviews EULAR 2018 and the past week's news and reports from RheumNow.com, including DMARDs in OA, the price of Penicillamine, Infections when ANCA+, CV outcomes in gout, NSAIDs in Pregnancy and Seropostive vs. Seronegative Outcomes.

CDC Obesity Prevalence Higher in the Rural USA

MMWR reports that approximately 46 million persons (14%) in the United States live in nonmetropolitan counties, where there is a higher prevalence of obesity-associated chronic diseases such as diabetes, coronary heart disease, and arthritis. (Citation source: http://bit.ly/2lj5yql)

EULAR 2018 - Podcast from Day 4

This EULAR 2018 Podcast is a compilation of audio clips from EULAR in Amsterdam.

Click HERE to listen.

You can also listen on iTunes, Soundcloud or Stitcher.