Friday, 19 Oct 2018

You are here

Vitamin D Fails to Improve Bone Health

The current edition of Lancet Diabetes & Endocrinology suggests that neither vitamin D supplementation, nor dose, will improve bone density or prevent fractures in adults. (Citation source: https://buff.ly/2O9tqxI)

A metanalysis of 81 randomized controlled trials included 53,537 subjects and varied in length ( 4 weeks to 5 years); most included women over age 65 years. 

Pooled data showed that vitamin D supplementation had no effect:

  • Fracture risk (36 trials; n=44 790, relative risk 1·00, 95% CI 0·93–1·07)
  • Hip fracture (20 trials; n=36 655, 1·11, 0·97–1·26)
  • Falls (37 trials; n=34 144, 0·97, 0·93–1·02)
  • Bone mineral density at any site (range −0·16% to 0·76% over 1–5 years).

The authors suggest there is little justification to use vitamin D supplements to maintain or improve musculoskeletal health. 

Disclosures: 
The author has no conflicts of interest to disclose related to this subject

Add new comment

More Like This

Zolendronic Acid Benefits Elder Women with Osteopenia

The NEJM reports that zolendronic acid was shown to significantly lower the risk of nonvertebral or vertebral fragility fractures in older women with osteopenia. 

Neuropathic Like Knee Pain

Fernandez and colleagues have shed further light on a significant subset of patients with knee pain - specifically, those with neuropathic like knee pain (NKP) that includes those with knee pain modified by central and peripheral neurologic dysfunction.

Knee Arthroscopic Surgeries on the Decline

A JAMA Internal Medicine report has shown that the rate of arthroscopic surgery has significantly declined, in an era when arthroplasty and the incidence of osteoarthritis (OA) has increased. (Citation source http://bit.ly/2DtpeUp)

Fractures May Lead to Systemic Bone Loss

Researchers at the University of California - Davis have shown that elderly women who had an upper body fracture or multiple fractures had more loss of hip density compared to those who who did not fracture. Systemic bone loss may increase the risk of future fractures. 

Maastricht Study Links Dairy Intake to Osteoarthritis

The Maastricht study explored the potential association between dairy consumption and knee osteoarthritis (OA), and found that higher intake of full-fat dairy and Dutch cheese - but not milk - was significantly associated with the lower risk of knee OA.