Monday afternoon's session on the treatment of Axial Spondyloarthritis presented us with a great selection of studies addressing important issues in modern treatment paradigm of AxSpA. Clinical and functional improvement with IL17 inhibitors in TNF naïve patients, incidence of IBD with IL17i, TNFi retention over time were amongst topics discussed.
Pegloticase has become an excellent option for management of patients with chronic refractory gout, although treatment may be limited by the development of anti-drug antibodies that lead to loss of serum urate (sUA) lowering effect.
While I’m only 7 years into a (hopefully) long career in the field of rheumatology, the pace at which we are seeing advances in new medications and earlier detection of rheumatoid arthritis requires you to continually refresh your approach to the disease.
We still haven’t displaced methotrexate and other conventional DMARDs, followed by TNF inhibitors for initial disease management.
We know that uveitis is an extra-articular manifestation of SpA but what remains unclear is if there are any factors that may play a role in the development of uveitis. One group sought to understand these issues.
RheumNow is in Chicago covering the ACR annual meeting. Here are the highlights from Sunday (day one). Be sure to check our complete coverage, including articles, video reports and tweets, at acr18.rheumnow.com.
By Sam Whittle, MBBS (Hons), MClinEpi, FRACP | 22 Oct 2018
During a fascinating gout session on October 21, Hyon Choi presented an important paper (abstract 874) which used data from the Health Professionals Follow-up Study to try to understand the rapid increase in the incidence of gout in recent decades.
During medical training, we were taught about rare diseases that are unlikely to be encountered, but there is a reason why our professors even mention these diseases. It is not just for our board exams; the lectures are for us to recognize the features of the disease when the rare patient comes across our exam table.
We are diving head first into flu season and we need to prepare ourselves. Last year we now know that 80,000 Americans died from influenza. I was happy to see the abstract presented in today’s plenary session by Colmegna et al about efficacy of high dose influenza vaccine in patients with rheumatoid arthritis (#837). This study was a randomized, modified double-blind, active-controlled trial carried out in adults with RA.
I am usually thrilled to offer Plaquenil as one of the safer therapy options to my patients with lupus and other autoimmune conditions. Unfortunately, on many occasions, once we go into detailed discussion of the potential side effects with the patient, the issue of hydroxychloroquine eye toxicity casts a cloud over overall optimistic view of Plaquenil.
Immune checkpoint inhibitors (ICI) have changed the hematology/oncology world. However, their AEs from a rheumatologic standpoint are still being evaluated and at this time, genetic risk factors for inflammatory arthritis due to ICI are not well understood. Dr. Cappelli et al evaluated a possible connection with HLA typing at their institution.
In the last few years, new studies have been published examining if early intervention and tight control (TC) of psoriatic arthritis (PsA) disease activity will have the same beneficial outcomes as it does for rheumatoid arthritis (RA).