Wednesday, 28 Jun 2017


The RheumNow Week in Review – 14 April 2017

Dr. Jack Cush reviews the past week's news, articles and advances from

Osteoporosis Drug Stopping by Rheumatologists - March Survey Results

The March 2017 RheumNow “Live Vote” surveyed US and non-US rheumatologists about their beliefs and practices regarding drug holidays for bisphosphonates and denosumab. Here are my responses and comments.

Acute Steroid Use Comes with Risk

Steroids are known for their acute therpeutic wonders and chronic hazards. Hence most practitioners are comfortable using short term, limited dose corticosteroids for a variety of ailments.

Celecoxib Plus PPI Preferred in High Risk Patients

When do the risks outweigh the benefits of NSAIDs use, especially in those with prior cardiovascular and gastrointestinal events? The CONCERN study has tested the effects of proton-pump inhibitor (PPI) in preventing GI bleeds when using NSAIDs and ASA.

Spinal Manipulation Equal to NSAIDS for Acute Low Back Pain

JAMA has published a review of 15 RCTs (1711 patients) analyzing the role of spinal manipulation therapy in patients with acute low back pain. The authors found modest improvements in pain and function at up to 6 weeks, with temporary minor musculoskeletal harms.

Stroke Risk Highest in the First Year of Lupus

Arkema et al has published in Annals of Rheumatic Disease a study showing that ischaemic and haemorrhagic stroke (CVA) is elevated in systemic lupus erythematosus (SLE) compared with the general population, especially in the first year. 

Osteoporosis Drugs of Uncertain Efficacy with CKD

More research is needed to determine the benefits and harms of osteoporosis medications on bone mineral density (BMD), fracture risk, and safety among patients with chronic kidney disease (CKD). This is important because complications of CKD include weak bones and increased fracture risk. The results of a systematic review and meta-analysis are published in Annals of Internal Medicine.

Osteoporosis Screening Indicated Following Non-Vertebral Fractures

The Archives of Osteoporosis have published the results of a cohort study supporting the use of osteoporosis (OP) screening in those sustaining a non-vertebral fracture in patients over age 50 years, independent of sex of level of trauma sustained.

Hydroxychloroquine Underperforms in a Cutaneous Lupus Trial

Hydroxychloroquine has become a mainstay in the treatement of patients with systemic lupus erythematosus (SLE) with proven efficacy in managing many domains of lupus, including skin, joint, and other autoimmune features.

The RheumNow Week in Review – 7 April 2017

Dr. Jack Cush reviews highlights from this week's meeting at the Cleveland Clinic Foundation - Biologics Summit VII; and of course a few other tweets and journal articles.

Biologic Safety Holds Up in RA

An updated systematic literature review has provided reassuring evidence regarding the increasing safety of biologic disease-modifying anti-rheumatic drugs (DMARDs) in the treatment of rheumatoid arthritis (RA), European researchers reported. 

Abatacept Use During Surgery

The issue of medication management is a complicated one, especially in complex rheumatoid arthritis (RA) patients taking biologic or immunosuppressive drugs.  The 2016 Annual ACR meeting saw new guidelines on perioperative management and a number of abstracts suggesting the safety and advantages of continued DMARD and biologic use in those undergoing major surgery.