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Weight Loss Improves Psoriasis

Jennsen et al previously reported their findings regarding weight reductions ability to improve cutaneous psoriasis at the European Academy of Dermatology and Venereology (EADV) meeting in 2015, Now their results are published in The American Journal of Clinical Nutrition. (Citation source:,

They examined long-term outcomes of weight loss in 56 obese patients with a mean PASI score of 5.4 and a body mass index of 34.4 kg/m2. Patients were randomized to a low-energy diet (LED) group or a control group given general advice to eat healthy foods.

The diet consisted of 8 weeks of a low-energy liquid (fortified drinks and soups) diet (800-1,000 kcal) followed by 8 weeks in which regular foods were reintroduced at 1,200 kcal/day. Patients underwent a 64-week weight-loss program consisting of an initial 16-week randomized phase with an LED for 8 weeks and 8 weeks of normal food intake combined with 2 LED products/day, followed by a 48-week period of weight maintenance with the latter diet. After the randomization phase, the control group received the same 8 + 8-week LED intervention, and all patients were then followed for 48 weeks while on the weight-loss maintenance diet.

After the initial 16-wk LED-only period, the mean weight loss was −15.0 kg along with a decrease in PASI (-2.3) and DLQI (−2.3). At week 64, the mean weight loss compared with baseline was −10.1 kg and the PASI and DLQI reductions were maintained at −2.9 and −1.9, respectively.

Long-term weight loss in patients with psoriasis has long-lasting positive effects on the severity of psoriasis.

The author has no conflicts of interest to disclose related to this subject

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