In RA, previously affected Jts more likely to flare ("joint-specific memory") ?mediated by synovial resident memory T cells, predominantly CD8+ T cells, with a restricted TCR repertoire, responding to specific Ags by releasing chemokines & cytokines https://t.co/VfFZ03yZYL https://t.co/npX3TGDe5A

Cross-sectional study of7887 NY & IL nurses: between 2018-21 top reasons for 2287 leaving nursing were planned retiring (39%), burnout (26%), insufficient staffing (21%), family obligations (18%) & COVID (17%)-- all addressable by health care employers https://t.co/Ls6p060mFB https://t.co/Pxpa8fqchz

Seasonal Pathogens and Henoch-Schönlein Purpura Epidemiologic studies of Henoch-Schönlein purpura (HSP) have suggested seasonal variation in occurrence rates (higher from September-April, lower in June-August), suggesting a role for infectious triggers. https://t.co/MmuVVziqv8 https://t.co/PhidOFTbFV

Pearl: Patients with persistent TMJ pain are more likely to have fibromyalgia than inflammatory or degenerative arthritis (as the underlying cause of their chronic pain) https://t.co/gCEm8A3RAT https://t.co/bvK2ii4fXP

IL-1 recept accessory protein (IL1RAP) shown to block mediators (IL-1, IL33, IL36) that may drive systemic sclerosis. In vitro, IL1RAP inhibited fibroblasts and endothelial cells; in mouse models of SSc anti-IL1RAP decr dermal & pulmonary fibrosis. https://t.co/jWjUMKdqGw https://t.co/O3o5iDHD6X

ICYMI: Top 5 Clinical Pearls in RA Management https://t.co/DphF8HcuHD https://t.co/CF9UuBCUxS

SLE in JAMA (authored by Drs Siegel & Sammaritano at HSS), impressive, full-read review, Covers: - Presentations: skin, Jts, brain, heme, etc - Treatments - Prognosis - Complications: CV, infx, CA - FAQs https://t.co/TPkm3BlrSw https://t.co/FqN1ZXyv4Y

1/600 Falls May Die (4.5.2024) Dr. Jack Cush reviews the news and Journal reports from this past week on RheumNow- including problems w/ falls, pain and treatment of Dupuytren’s contractures. https://t.co/37JSS1fbLi https://t.co/WEwjntAQEt

Serious Infections in Takayasu arteritis The large vessel vasculitis, Takayasu arteritis (TAK), carries a significant morbid risk and a cohort analysis shows these patients are also at high risk of serious infection with resultant higher risk of death. https://t.co/qqtpCMYnZf https://t.co/ZlxATKVQIA

Canadian OBRI study in 692 RA pts shows pts treated w/ triple DMARD (MSH) stayed on Rx longer (15 mos) compared to MTX+LEF (9.6 mos); not significant but MTX/SSZ/HCQ had signif lower DAS28 @ 6 mos (3.4 vs 3.9) & at 12 mos (3.2 vs 3.5, p=0.0005) https://t.co/tuIigaswDK https://t.co/DAh3lgRufA

Primary care pop. study pts shows poor health literacy in gout pts assoc. w/ more gout flares. Study of 551pts; 30% w/ 2+ flares in 12 mos; 9.4% w/ poor health literacy. pts had more flares (OR 4.1) & hx of oligo/polyarticular flares (OR 1.93) https://t.co/tDiFqixbLV https://t.co/Kb75iJwTZE