Tuesday, 15 Oct 2019

Autoimmune/Lupus

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14 Oct 2019 Social Comparison of 69 SLE pts w/ C/S+ infection vs 69 SLE without infx shows that serum procalitonin did not distinguish those w/ infection, BUT C-reactive protein did successfully identify those SLE patients with infection https://t.co/HMHqfaP0Cg
14 Oct 2019 Social Taiwanese Claims data study shows the risk of opportunistic infection in ~77K autoimmune pts shows OI highes in PM/DM cases (61.3/1000PY), followed by SLE (43.1/1000PY), SSc (31.6), RA (25), and pSS (24.1). OI risk highest during 1st year https://t.co/YKP7ZF7FIx
09 Oct 2019 News Declining Trends in Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis Mortality in the USA
08 Oct 2019 News Serum Interferon Predicts Lupus Flares
07 Oct 2019 Social T2T in Lupus Nephritis aims for less proteinuria, Study of 87 pts with class III/IV LN compared goal of urine protein/creat ratio(UPCR) < 0.5 to stringent < 0.15, Latter assoc w/ lower renal flares (HR  0.16), less CKD (HR 0.19), more MMF use (HR = 7.26) https://t.co/0LSXTiUAaV
05 Oct 2019 Social RT @LCalabreseDO: Looking forward to giving plenary talk at #ACR2019 at 11AM Sunday on practical aspects of vaccines(flu/pneumo/VZV) for au…
04 Oct 2019 News ILD Patients At Risk for Autoimmune Disease
01 Oct 2019 Social Kaiser study of 1956 SLE patients shows only 58% of were adherent (≥ 80%) to hydroxychloroquine; not predicted by the Rheum, hospital or socioeconomics. Risk factors for nonadherence included age, being white, # of Rheum visits/yr. https://t.co/qRdJRGvRAr
30 Sep 2019 Social A&R reviews the inflammasome in autoimmune diseases. Pattern recognition recpt induce inflammasome activation, pro-caspase-1 converts to caspase-1 convertin pro-IL-1β and pro-IL-18 active IL-1β and IL-18; seen in RA, SLE, gout, Sjogrens https://t.co/JGadiEWQWf
28 Sep 2019 Social The RheumNow Podcast is up - discussing PSS & Cancer, SLE & narcotics, AAV & Lipids, Anakinra & NIDDM. Watch it here>> https://t.co/PolTYQqbBW or listen to the podcast on iTunes, or SoundCloud>> https://t.co/ILQQw2kpse
26 Sep 2019 News MMWR: Increased Opioid Use in Lupus
25 Sep 2019 News Low Dose IL-2 Effective in Lupus
20 Sep 2019 Social 90 SLE pts (SLEDAI<6) on immunosuppressives were given PBO or Live Virus zostavax - Vax pts had significantly higher Wk 6 anti-VZV IgG, more injection site reactions (31 vs 7%). 3 pts flared (1PBO; 2 Zostavax) and no one developed zoster postvaccination https://t.co/pVrQ4tHAwY
20 Sep 2019 Social Risk of HCQ/CQ Retinal toxicity was 5.5% in 326 SLE pts F/U x 12.8 yrs. None occured in 1st 5 yrs; earliest 8 yrs (max =33 years). Retinal toxicity cases tended to have more renal disease (22% vs 15%) and were slightly less likely to be Caucasian https://t.co/kSFVedbUPY
19 Sep 2019 Social Metanalysis of 16 studyes Systemic Sclerosis pregnancies have a higher risk of miscarriages (OR 1.6), IUGR (OR 3.2), preterm births (OR 2.4) and low birth weight (OR 3.8). SSc pts have 2.8 fold higher rate of gestational HTN & 2.3x more C- sections. https://t.co/FuM0DZFR4k
18 Sep 2019 News Sensitivity of Temporal Artery Biopsy
18 Sep 2019 News FDA Grants Breakthrough Status for Potential Lupus Nephritis Drug
17 Sep 2019 Social Despite RCTs showing RTX doesnt work in SLE - rheums still use it. Review of 147 SLE pts on RTX shows better outcomes in those w/ a low # prior DMARDs & low C4 levels. Lesser resp w/ Joint dz. (>1/2 had prior MMF, AZA, HCQ; 1/3 CTX or MTX) https://t.co/XlGGulpLDW
16 Sep 2019 Social Despite several Vitamin D intervention RCTs in SLE failing; a metanalysis shows Vit D levels low in SLE, esp if SLEDAI >10. Deficiency of Vit D incr SLE risk (OR=4.37) and Vit D levels were inversely correlated with SLEDAI (correlation coefficien = −0.50) https://t.co/M39lzISw09
15 Sep 2019 Social RT @sclerodermaUM: I found this to be extremely helpful for recommending cannabinoids. https://t.co/5NkQzurbnK