Thursday, 21 Nov 2019

Autoimmune/Lupus

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11 Nov 2019 Social RT @Janetbirdope: SLE has high work disability. Interestingly work disability was not high in some organ systems such as renal but mild GN…
11 Nov 2019 Social RT @MaeveGamble: “It’s so rare that a lupus clinical trial makes it to a plenary session...so cherish the moment!” -Dr Richard Furie on ani…
11 Nov 2019 Social RT @EBRheum: TULIP1 Anifrolumab RCT in SLE Did NOT meet primary endpt SIR4 wk52 (36% v 40% PLBO, NS) Post Hoc BICLA response DID favor Tx…
04 Nov 2019 Social Retrospective study from Spanish SLE register RELESSER: in 3539 SLE patients, the risk of cancer was elevated (SIR=1.37; CI 95%: 1.15‐1.59), higher in women (SIR=2.38). SLICC Dz activity and ACE inhibitor use was assoc w/ non-Hormone sensitive CA https://t.co/epJsTdblpX
04 Nov 2019 Social Cardiac ECHO in 223 neonatal lupus pts - Those with abnormal ECHO in the 1st year, 44% continue to have abnormalities, but 56% revert to normal. If normal in 1st yr, 9% developed new dysfunction between 1-17 yrs of age, 6.5% in adulthood. https://t.co/EJDsK5ABQ8
30 Oct 2019 Social Persistently frequent use of emergency department (ED) by lupus patients was primarily for pain by SLE pts who were more apt to be on narcotics. Pain management in SLE appears to be a significant challenge, if not unmet need. https://t.co/u9aM8pajZ8
29 Oct 2019 Social UTSW retrospective study of 118 Cutaneous LE patients without prior SLE (13 SCLE; 105 chronic CLE; 87 DLE) , finds 12.7% with prior-onset autoimmune dz (thyroid, Sjogrens, etc) . M median time from CLE Dx to new autoimmune disease was 7.3 yrs https://t.co/aprNyOHhqJ
17 Oct 2019 News Protective Effects of ASA and Vasodilators in Systemic Sclerosis
16 Oct 2019 Social Single center study of anti-PhosphoLipd Abs in 149 Bx proven lupus nephritis pts 36% had APL Abs (18.8% IgG, 18.1% IgM, 10.7% B2GlyP, 8.1% LAC). F/U of 156 mos - APL+ had lower 10 yr survival (91 vs 99%). lower GFR, more thrombotic events & miscarriage https://t.co/U5ra02wMmX
16 Oct 2019 News Myositis Patients at High Risk of Opportunistic Infections
15 Oct 2019 News Warfarin Superior to Xarelto in Antiphospholipid Syndrome
14 Oct 2019 Social Comparison of 69 SLE pts w/ C/S+ infection vs 69 SLE without infx shows that serum procalitonin did not distinguish those w/ infection, BUT C-reactive protein did successfully identify those SLE patients with infection https://t.co/HMHqfaP0Cg
14 Oct 2019 Social Taiwanese Claims data study shows the risk of opportunistic infection in ~77K autoimmune pts shows OI highes in PM/DM cases (61.3/1000PY), followed by SLE (43.1/1000PY), SSc (31.6), RA (25), and pSS (24.1). OI risk highest during 1st year https://t.co/YKP7ZF7FIx
09 Oct 2019 News Declining Trends in Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis Mortality in the USA
08 Oct 2019 News Serum Interferon Predicts Lupus Flares
07 Oct 2019 Social T2T in Lupus Nephritis aims for less proteinuria, Study of 87 pts with class III/IV LN compared goal of urine protein/creat ratio(UPCR) < 0.5 to stringent < 0.15, Latter assoc w/ lower renal flares (HR  0.16), less CKD (HR 0.19), more MMF use (HR = 7.26) https://t.co/0LSXTiUAaV
05 Oct 2019 Social RT @LCalabreseDO: Looking forward to giving plenary talk at #ACR2019 at 11AM Sunday on practical aspects of vaccines(flu/pneumo/VZV) for au…
04 Oct 2019 News ILD Patients At Risk for Autoimmune Disease
01 Oct 2019 Social Kaiser study of 1956 SLE patients shows only 58% of were adherent (≥ 80%) to hydroxychloroquine; not predicted by the Rheum, hospital or socioeconomics. Risk factors for nonadherence included age, being white, # of Rheum visits/yr. https://t.co/qRdJRGvRAr
30 Sep 2019 Social A&R reviews the inflammasome in autoimmune diseases. Pattern recognition recpt induce inflammasome activation, pro-caspase-1 converts to caspase-1 convertin pro-IL-1β and pro-IL-18 active IL-1β and IL-18; seen in RA, SLE, gout, Sjogrens https://t.co/JGadiEWQWf