Monday, 18 Feb 2019

Autoimmune/Lupus

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27 Nov 2018 Social Musculoskeletal/Rheumatic diseases (arthralgias, myalgias, arthritis, PMR, myositis, Sjogrens, SLE) are uncommon side effects of immune checkpoint inhibitors, so-called irAE (immune related adverse events). Good review here. https://t.co/R52SW0HUjv
02 Nov 2015 Social Uncontrolled trial of Perfenidone (antifibrotic) gel in 12 pts w/ localized scleroderma shows major skin benefits https://t.co/b2myM0uZVv
12 Aug 2016 Social Great review of Raynauds Phenomenon in NEJM by Dr. Fred Wigley https://t.co/pzxpQlNQFH
30 Apr 2017 Social RT @DrRachelTate: MALT more common than diffuse B cell lymphoma in Sjogrens pts. A Baer, MD @RheumNow #SOTA2017 https://t.co/GnEuD3JULd
30 Aug 2016 Social Dr. Langford: VTE is increased risk w/ active GPA, MPA or EGPA. However no current evidence attesting to need for automatic anticoagulation
04 May 2016 Social May is lupus awareness month. https://t.co/Ri6ZOQ7Ae9
05 May 2015 Social Study of 513 GPA (Wegeners) patients; 3.3% had cardiac involvement - unrelated to ANCA positivity or disease activity http://buff.ly/1R7HwIp 
03 Nov 2017 Social Comparison of familial and sporadic SLE - Photosensitivity, thrombocytopenia renal more in sporadic SLE. https://t.co/VgizQzN6xq
07 Nov 2017 Social RT @_connectedcare: ANA as a screening test is problematic given this low specificity. Leads to so much anxiety #ACR17 @RheumNow https://t.…
23 Jan 2018 Social Among 286 SLE from the NHS, 42% were dsDNA+ at diagnosis. Current smokers were more likely to be dsDNA+ (HR 1.86) & >10 Pk-yr hx had elevated dsDNA+ SLE risk (HR 1.60) https://t.co/0RSI7r3zWP
25 May 2018 Social Registry of 509 women with SLE had 719 children showed that compared to matched controls, children born to mothers with SLE had No greater risk of a systemic rheumatic autoimmune diagnoses. https://t.co/RmKXyOuLyQ
17 Jan 2019 Social A scleroderma/Raynauds patient just showed us her favorite XMAS gift - an Electric Hand Warmer - you can buy these on Amazon for $15-30. Very Cool!! https://t.co/My06QzcHhj
04 Sep 2015 Social Cogan's syndrome:Rare, w/ interstitial keratitis & sensorineural hearing loss +/- syst vasculitis. Rx steroids, INFLX http://t.co/xwqgrGu6fI
05 Dec 2016 Social Catastrophic antiphospholipid registry:500 pts, 30% SLE, death in 37%; renal 73%, lung 60%, half w/ CNS, heart, skin https://t.co/3fWqYlLZ4p
14 Apr 2017 Social Anabasum is a oral endocannabinoid-mimetic binds to CB2 receptor, will enter a phase III trial in Systemic sclerosis https://t.co/2qeDOA32bT
18 May 2017 Social 189 SLE pts F/U for 13yrs; 53-59% lower risk of CV events if on ASA &HCQ, but APL Ab+ or HTN incr CV risk 18 fold https://t.co/O5PAOjIyv3
28 Sep 2016 Social IL-6 inhibitor (PF-04236921) NOT effective in SLE;186 pts RCT- 3 doses same as placebo in SRI-4, BICLA responses https://t.co/xBc3D9ONH3
01 Jun 2016 Social Rituximab fails to be effective treatment for calcinosis. https://t.co/OqWwxdlvK7
03 Jun 2015 Social RCT of sildenafil vs PBO in PSS ischemic digital ulcers(DU): A nonsignif. trend for DU w/ sildenafil; PBO also healed http://t.co/SpBWnKeq7L
17 Feb 2016 Social Biomarkers predictive of decline in Renal Funct in lupus nephritis: LFABP, urine MCP-1, albumin, transferrin https://t.co/yHGmivkoQo