Monday, 24 Feb 2020

Biologic/Novel Rx

Date Typesort ascending Title Save
07 Dec 2017 Social Prospective study of 133 IBD pts (64% CD, 36% UC) switched from Remicade to biosimilar Inflectra. After 12 mos. no differences in drug levels, disease activity between innovator and biosimilar.
22 Nov 2016 Social RT @DrPetryna: Sarilumab (IL6R) superior to Humira in MONARCH phase 3 trial. neutropenia &abn LFT > with sarilumab…
03 Oct 2018 Social RT @RheumNow: Often Not discussed but do you combine Otezla with a biologic (TNFi or IL-17 inhibitor) in your difficult PsA patients? Rheum…
15 Mar 2016 Social 63 Actemra nonresponders switched to TNFi (41) or Orencia (22) - more TNFi achieved LDAS (CDAI<10) (64% vs 24% ABA)
30 Apr 2015 Social Negative RCT of RTX vs PBO in pts w/ ITP (PLT<30k) on background steroids. No difference in response or relapse rates 
29 Jan 2017 Social CHMP sends a positive recommendation for tofacitinib to the EMA. This would be for the 5 mg bid dose mod-severe RA
12 Jan 2017 Social Biosimilar Inflectra priced at only a 15% discount; CMS issues paymentand claims processing information
05 Nov 2018 Social Oct 31st Sandoz announced that the FDA has approved its adalimumab biosimilar named Hyrimoz (adalimumab-adaz) with indications for RA, JIA, PsA, AS, Crohns, ulcerative colitis and plaque psoriasis.
05 May 2016 Social There is insufficient evidence that platelet rich plasma treatment benefits patellar tendinopathy.
19 Aug 2017 Social RheumNow Wk in Review up! How to store enbrel, over/under testing. Check out podcast video
01 Jan 2020 Social Do biologics work in relapsing polychondritis? French cohort of 41 pts use 105 biologics (TNFi=60; TCZ 17; anakinra 15; RTX 7; ABA6). While 63% resp in 1st 6 mos (on pred!), a complete response rate was 19%. Steroid sparing variable, high infx rates.
13 Nov 2019 Social RT @EBRheum: Great talk by Dr. Manzi for Year in Review! See my recent podcast about SPIRIT-H2H. It shows that IXE > ADA for skin but NO…
23 Jun 2016 Social 47 RA/Psoriasis women exposed to Tofacitinib: 25 healthy, 1 congen. pulm stenosis 7 spont abortions. 8 terminations…/
17 Feb 2017 Social ORAL strategy trial shows Xeljanz +MTX = Humira +MTX; but was inferior as monoRx Xeljanz in 1152 RA pts over 12 mos
24 May 2018 Social Sandoz announces the approval of its infliximab biosimilarZessly (infliximab) by the European Commission. It is approved for use in RA, , adult & pediatric Crohn’s, adult & pediatric ulcerative colitis, AS, PsA and plaque psoriasis
10 Jun 2016 Social BMS Orencia data presented @ #EULAR16; including #CORRONA data showing RF+ or CCP+ assoc w/ better Orencia responses
13 Sep 2017 Social Sandoz announces FDA will review its biosimilar version of rituximab
06 Jul 2015 Social Pfizer has submitted to the FDA (for review) a new once-a-day Xeljanz (tofacitinib) 11 mg qd (equal to 5 mg bid)
23 Aug 2016 Social Idiopathic Recurrent Pericarditis follows ~20% acute pericarditis; responds VERY well to IL-1 inhibition (anakinra)
07 Apr 2017 Social Dr. Laura Cappelli - Talk on checkpoint inhibitors of PD-1 (nivolumab, pembrolizumab) and CTLA4 (impilimumab) commonly used in chemotherapy