Monday, 24 Feb 2020

Biologic/Novel Rx

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09 Aug 2016 Social In Japan, persistence on biologics highest in biologic-naïve (>95%) and older Pts & lowest w/ more comorbidities.
01 Oct 2018 Social Hear nine experts talk about biosimilars in Therapeutic Update: Biosimilars, a video series brought to viewers by Sandoz. Now available on RheumNow. #sponsored #biosimilars
12 Jul 2018 Social RT @ByJonGardner: Some interesting insight on why US biosimilar uptake has been so anaemic from a Leerink note. Main reasons: PBMS lose mon…
05 Dec 2017 Social FDA listing of currently approved BIOSIMILARS and their product info. 5 of 8 are for rheumatology, think you know them?
08 Aug 2017 Social Tanezumab (MAb against nerve growth factor) is being fast-tracked by FDA as a non-opioid pain reliever.
28 Sep 2016 Social Yale study of Alopecia (areata or universalis) showed 32% of 66pts improved with tofacitinib 5mg bid after 3 months.
25 Oct 2018 Social RT @WIRheum: Canabinoids in vitro CB2 receptor drives inflammation Set the stage for discovery/development of future antagonists? Danger…
29 Jul 2019 Social Measures used to limit costs & utilization of expensive biologics: 1) Generics 1st requirement; 2) Pre-authorization; 3) limited (6-9 mos) approval w/ proof of benefit; 4) 30 day supply; 5) preferred tiered drugs; & 6) utilize less expensive providers
04 Apr 2017 Social FDA grants "breakthrough status" (expedited review) for Rituximab in Pemphigus Vulgaris based on recent Lancet study
25 Jun 2015 Social Antecdotal reports of tofacitinib success in resolving depigmentation of vitiligo.
22 Feb 2018 Social of Derm mtg in San Diego has several new biologic therapies of Atopic Dermatitis, including baricitinib, upadacitinib, ASN002 (JAK/SYK inhibitor) and anti IL-33 (ANB020).
17 Nov 2016 Social RT @DrAiLynTan: Great slide on comparing biologic therapy in #rheumatoidarthritis v #Crohns v #ulcerativecolitis via @JoseCamposMD #ACR16 h…
11 Oct 2017 Social Multicenter study of135 JIA pts who stopped biologic - 76% flared; more if W/D tried before 2 years of remission.
03 Apr 2016 Social IMS Health estimates $92 billion in global sales of branded drugs & biological products will have lost patent protection between 2011 & 2015
28 Nov 2019 Social RT @RheumNow: Abstract L06 shows the efficacy of Emapalumab, an IFN-γ mAb, when given to 9 systemic JIA pts who developed macrophage activ…
01 May 2017 Social OPT 1&2 RCT show Tofacitinib to improve nail psoriasis: NAPSI75 scores PBO 6.8%, Tofa 5mg 16.9%, 10 mg 28.1% bid
01 Sep 2015 Social Is there a role for IVIG management? Infx or biologic contraindicated pts, vasculitis, Stills, rhupus, overlap?
06 Jun 2018 Social The FDA has a new Video Series on Biosimilars - The Promise: new options, $ competition - The Basics: key terms & concepts - Interchangeability: defining the standard - The Development: abbreviated licensure path - The Data: analytics & approval process
06 Nov 2017 Social RT @regeneron: In rheumatoid #arthritis, chronically elevated IL-6 levels may drive inflammation & joint destruction. #ACR17…
23 Apr 2019 Social CORRONA study of 880 RA pts w/ hx of Solid cancer shows many on biologics following Dx. 42% were on biologics/tsDMARDs in the 12 mo before cancer. Post CA 31% were on same Rx, 5% switched biologics &10% started a biologic, the majority starting TNFi (54%).