Friday, 17 Jan 2020

Biologic/Novel Rx

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29 Apr 2019 Social FDA has approved Samsung-Bioepsis biosimilar version of etanercept - Eticovo (etanercept-ykro), approved in other countries under names Benepali and Brenzys. Approval based on 596 RA pt trial w/ 52 wk ACR20 of 80.8% and 81.5% (Enbrel arm) https://t.co/r3q9dQ0Bdb
24 Apr 2019 News Ustekinumab Effective in Behcet's Disease
23 Apr 2019 Social CORRONA study of 880 RA pts w/ hx of Solid cancer shows many on biologics following Dx. 42% were on biologics/tsDMARDs in the 12 mo before cancer. Post CA 31% were on same Rx, 5% switched biologics &10% started a biologic, the majority starting TNFi (54%). https://t.co/PjjQvFVnsI
18 Apr 2019 News Polypharmacy Blunts Responses and Ups the Safety Risks
11 Apr 2019 Social 117 pregnancies exposed to biologics were compared to 585 pregnancies not exposed to biologics; 6% of newborns had ≥1 congenital anomalies. No significant association between biologic exposure and congenital anomalies (HR 1.06; 95%CI 0.46-2.47) was seen. https://t.co/bLOtPTmpL1
04 Apr 2019 ACR Video A Video Collage of RheumNow Live 2019
01 Apr 2019 News RheumNowLive On Demand: Development & Use of JAK Inhibitors - Dr. John O'Shea
28 Mar 2019 News For RA With COPD, Abatacept is Safe
28 Mar 2019 News Best of 2019 - Ups and Downs with Abatacept
27 Mar 2019 Social Murine BM–derived macrophages or human monocytes treated w/ tofacitinib or selective JAK1, JAK3 inhibitors. Both TOFA & JAK1i but not JAK3i effectively inhibited STAT1 phosphorylation & IFN gamma production, suggesting affects on macrophage function. https://t.co/qILxzCDrCH
26 Mar 2019 Social Boehringer Ingelheim announce s FDA and EMA regulatory submission for nintedanib in systemic sclerosis associated ILD https://t.co/BQz94Kg4Px
18 Mar 2019 News No Rise in Cancer Risk with Actemra
13 Mar 2019 ACR Video QD Clinic - Secondary Loss of Efficacy
13 Mar 2019 News First Line IL-1 Inhibition in Systemic JIA
11 Mar 2019 ACR Video QD Clinic - Biologic Class Switching
25 Feb 2019 Social ERRATA: "How to Handle Latex Allergies and Biologics" - has been corrected to show that the Cimzia PFS DOES contain 7% of a plastic derived from natural rubber latex. Latex- sensitive patients should be advised to handle the needle shield with caution. https://t.co/ThLns4C5Jt
22 Feb 2019 ACR Video QD Clinic - Rules for Pregnancy
20 Feb 2019 News Impressive Survival of Interleukin-1 Inhibitors in Systemic Juvenile Idiopathic Arthritis
20 Feb 2019 News Safety Warnings for Higher Dose Tofacitinib
19 Feb 2019 ACR Video QD Clinic - When to Stop Anakinra