Tuesday, 25 Sep 2018

Bone/OP&OA

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20 Jul 2018 Social Pfizer & Lilly report on Phase 3 Tanezumab (NGF inhibitor) in 698 Knee or Hip OA pts. At 16wks TNZ yielded significantly better pain, function & the Pt Global (vs PBO). Rapidly progressive OA seen in <1.5% on TNZ; 0 on PBO. https://t.co/AubO4PyYJQ
19 Jul 2018 Social 4543 patients followed for mean 8.4 yrs, crude incidence of knee chondrocalcinosis was 3.2 per 1000 PY and whole cumulative incidence of chondrocalcinosis was 2.7%, more with age and higher HbA1C https://t.co/gdlvmYDlPd
17 Jul 2018 Social Amgen and UCB have re-filed for FDA approval of osteoporosis drug romosozumab one year after a complete response letter citing CV risks. New data includes 7,180 ph3, 4,093 ph3 and a 245 pt male OP trial. https://t.co/evemBRXrpP
15 Jul 2018 Social Sytematic review of supplements for osteoarthritis finds (despite poor quality studies) Limited research evidence to recommend the oral use of Boswellia serrata extract and Pycnogenol, curcumin and methylsulfonylmethane https://t.co/I6ioJn6wDF
02 Jul 2018 Social Metanalysis of 11 RCTs show that DMARDs and biologics are no better than Placebo in treating symptomatic Osteoarthritis https://t.co/OGwvaEglhZ
27 Jun 2018 Social 233,608 statin initiators not shown to increase the risk of hand osteoarthritis when compared 1:10 with non users (from UK Clinical Practice Research Datalink) https://t.co/FLQnfBAfdl
21 Jun 2018 Social Metanalysis of 11 RCTs show that DMARDs and biologics are no better than Placebo in treating symptomatic Osteoarthritis https://t.co/OGwvaEglhZ
16 Jun 2018 Social RT @DrAiLynTan: Secondary #osteoporosis in systemic mastocytosis! Prevalence ~ 30% Beware in cascade of multiple vertebral #fractures! m…
16 Jun 2018 Social Dr. David Felson shows bone marrow lesions correlate well with pain of osteoarthritis, and may improve either treatment. from #EULAR SP0152 https://t.co/Jy94IwdPYQ
16 Jun 2018 Social Felson shows diastolic BP shows 2x risk of OA from #EULAR SP0152
15 Jun 2018 Social RT @DrAiLynTan: Osteonecrosis of the #jaw & antiresorptive treatments statistics, prevalence & incidence via Roux #EULAR2018 #ONJ #mand…
15 Jun 2018 News Update on Osteoporosis
13 Jun 2018 Social Denosumab (Prolia) was approved by the European commission for use in glucocorticoid induced osteoporosis (GIOP) for use in the EU. Timing is perfect given all the GIOP and SIOP abstracts presenting at #EULAR2018 https://t.co/isltyIwpfi
13 Jun 2018 Social Curtis/Saag present data on 150,000 women on Bisphosphonates (BP); 40% d/c for >6mos. W/in 2 yrs theres a 20% incr risk of fracture, higher (40%) after 2 yrs, but less in prev Fosamax Rx pts #EULAR2018 @RheumNow OP0017
13 Jun 2018 Social RT @RonanTKavanagh: @Janetbirdope @RheumNow Especially if DXA hip osteoporosis.
13 Jun 2018 Social RT @RonanTKavanagh: Minten. Low dose radiotherapy not effective for hand and knee OA. Patients randomised to low dose radiotherapy vs Sham…
13 Jun 2018 Social RT @DrAiLynTan: Zolendronic acid didn't significantly reduce cartilage volume loss, #knee pain or bone marrow lesion size in knee #osteoa…
04 Jun 2018 Social JBMR reports a single center study showing that among 53 severe osteoporosis patients treated w/ teriparitide, hypomagnesemia was seen in 36% - risk factors include older age and lower baseline Mg levels. Consider monitoring Mg https://t.co/NUKwHjWkq8
03 Jun 2018 Social FDA approves the combo drug Consensi (amlodipine and celecoxib) for Treatment of Hypertension and Osteoarthritis Pain - is this brilliant of an expensive brand of stupid? https://t.co/RZO0wOl6T8
25 May 2018 Social RheumNow Wk in Review is up! Hot news on CIRT, OP, MPO & what SLE will and wont do. Checkout podcast on iTUnes or here https://t.co/0vxHMCOfHD