Monday, 11 Nov 2019

Bone/OP&OA

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25 Jun 2019 Social 2,899 RA and 112,571 OA pts had THA or TKA. RA had more infections (HR 1.29;1.03-1.61) post THA/TKA, but fewer VTE (HR 0.60; 0.26-0.98) post TKA. Biologics in RA had a similar infx risk but more VTE (HR 4.82;1.67-13.9) vs non-biologics. https://t.co/Lv1QLbjZjx
24 Jun 2019 Social After reviewing the safety data, the FDA has removed the risk ofosteoporosis and fracture from the drug facts listing for OTC proton pump inhibitor (PPI) medications https://t.co/RnjtTl2oVV
18 Jun 2019 Social RT @GoutGroup: Achilles’ tendon issues can be painful and disabling, and are something we all want to avoid. Dr Simon Otter presents imagin…
17 Jun 2019 Social RT @sclerodermaUM: Going beyond scleroderma. 1. Tanezumab is effective for OA related pain and no new safety concerns. #EULAR2019 https://…
04 Jun 2019 News Knee Injuries Increases Osteoarthritis Risk
02 Jun 2019 Social Prospective study of 4796 pts in the Osteoarthritis Initiative shows metformin use in obese pts (BMI>30) was Assoc with significantly less medial cartilage loss (0.71% vs. 1.57%/yr) & a trend towards fewer knee replacements over 6 yrs (OR 0.30, p = 0.11) https://t.co/LD0jFWtSLM
30 May 2019 Social In a study of 678 first-degree relatives (FDRs) of RA patients and 330 osteoarthritis (OA) subjects, increasing age is associated with increasing positive results for the CCP3.1 and CCP-IgA test results - just like RF. https://t.co/0iwK0CjxUj
29 May 2019 Social Research by Robinson and colleagues at Stanford show that mast cell inhibition or depletion significantly improved osteoarthritis in a mouse model. Mast cell driven tryptase increases inflammation, chondrocyte apoptosis, and cartilage breakdown https://t.co/LpgZUhDHvQ
28 May 2019 Social Prospective study of 4796 pts in Osteoarthritis Initiative shows metformin use in obese pts (BMI >30) was Assoc with significantly less medial cartilage loss (0.71% vs. 1.57%/yr) & a trend towards fewer knee replacements over 6 yrs (OR 0.30, p = 0.11) https://t.co/LD0jFWtSLM
23 May 2019 News Additive Effects of Insomnia and Depression on Osteoarthritis
22 May 2019 Social Fibomyalgia patients who undergo Knee replacements have significantly more complications (OR 1.55), revisions (OR 1.5), mechanical loosening (OR 1.34) & infection (OR 1.33). MDs and FM pts should be made aware of increased postoperative risks. https://t.co/muFQoco9zg
21 May 2019 Social US Supreme court has rejected lawsuits against Merck & Fosamax over rare atypical femoral Fx and has directed the lower court to reconsider ruling allowing lawsuits against despite the FDA denying Mercks attempt to update the label about fracture risk https://t.co/xvJlDntuuK
17 May 2019 Social Review of Factors Contributing to Functional Outcomes after Knee replacement includes: Weight, pain & smoking (increase post-op complications), pain, infection (2% w/in 1st 90days), post-operative range of motion and (severity of) the OTHER knee. https://t.co/mKe8EQnk8q
06 May 2019 News CDC: One in Four US Adults have Arthritis
02 May 2019 Social Osteoarticular involvement with sarcoidosis is uncommon (<13%); in the hands shows a honeycomb/latticework trabecular pattern in metacarpals https://t.co/bE4VgWaEzN
25 Apr 2019 News More Studies Needed to Optimize the Use of Osteoporosis Drugs
24 Apr 2019 ACR Video RheumNow Live Preview with Dr. Kenneth Mathis
23 Apr 2019 News NIH Workshop on Unmet Needs in Osteoporosis
22 Apr 2019 Social RCT of 63 knee OA pts - given PBO or 40 g/d freeze-dried blueberry powder x 4 mos. Significant improvement in WOMAC total, Pain scoresand ADL scores in the blueberry group, but no change in TNFα,IL-1β, IL-6, IL-10, IL-13, MMP3, MMP-13, MCP-1 levels. https://t.co/wHzCJDOuiJ
19 Apr 2019 Social Phase 3 study tanezumab (anti-NGF) 2.5 mg or 5 mgin knee or hip OA find that 5 mg met 2/3 of 3 primary endpoints at 16wks; but the lower dose failed to be superior to NSAIDs in this 1 yr study. Safety outcomes where less favorable w/ tanezumab. https://t.co/l4Qffdn1nl