Monday, 16 Sep 2019

Bone/OP&OA

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23 Apr 2019 News NIH Workshop on Unmet Needs in Osteoporosis
22 Apr 2019 Social RCT of 63 knee OA pts - given PBO or 40 g/d freeze-dried blueberry powder x 4 mos. Significant improvement in WOMAC total, Pain scoresand ADL scores in the blueberry group, but no change in TNFα,IL-1β, IL-6, IL-10, IL-13, MMP3, MMP-13, MCP-1 levels. https://t.co/wHzCJDOuiJ
19 Apr 2019 Social Phase 3 study tanezumab (anti-NGF) 2.5 mg or 5 mgin knee or hip OA find that 5 mg met 2/3 of 3 primary endpoints at 16wks; but the lower dose failed to be superior to NSAIDs in this 1 yr study. Safety outcomes where less favorable w/ tanezumab. https://t.co/l4Qffdn1nl
17 Apr 2019 Social Lateral wedge insoles are often used medial knee OA. Study of 63 preselected pts shows a significant pain reduction (vs neutral soles) but mean difference was 0.7 on 0–10 scale; thus benefitting only a minority of pts https://t.co/7SK7Cl1Uft
16 Apr 2019 News Intraarticular Trans-Capsaicin Effective in Knee OA
16 Apr 2019 News Smoking Not Protective Against Knee OA
16 Apr 2019 Social The price of new osteoporosis drug Evenity (romosuzumab; sclerostin inhibitor) is $1,825/mo. or $21,900/Yr; Just FDA approved for post-menopausal OP at high risk for Fx . Amgen estimates Evenity to be 34-74% lower than Tymlos & Forteo. https://t.co/lYHyukTRPw
15 Apr 2019 Social Metanalysis of 6 studies suggests that metformin use was inversely associated with the risk of fracture (RR 0.82; 95% CI 0.72, 0.93). https://t.co/ZTmHnpMvS6
10 Apr 2019 News FDA Approves Romosuzumab (Evenity) for High Risk Osteoporosis
09 Apr 2019 Social Data from the Osteoarthritis Initiative (n 4369) shows that fluctuating or persistent Knee pain over 1 yr had an increased risk of cartilage volume loss and structural progression over 4 years (OR 1.62, 95% CI 1.04–2.54) https://t.co/Inf4WsQ4Lz
27 Mar 2019 News Guidelines for Osteoporosis Management in Postmenopausal Women
23 Mar 2019 Social Dr Phil Conaghan on the similarity between OA and PsA #RNL2019 https://t.co/za9YDAWilE
21 Mar 2019 Social A review of OP Guidelines, published in Osteoporosis International, shows only 27 of the 70 guidelines patient Beliefs, Values or Perceptions. https://t.co/zGoX2aaxdP
21 Mar 2019 Social AAOS meeting presentation of 114,698 TKR pts shows younger pts (age <40) have a 3 fold greater risk of early mechanical complications & are 63% more likely to be rehospitalized w/in 90D. Younger have more obesity, DM, inflamm arthritis, ACL surgery https://t.co/DoePD5GXl9
20 Mar 2019 Social QD Clinic - Goldilocks and Osteoarthritis | RheumNow - Finding the Right Ddose for the Right Patient? https://t.co/SMmVYDxPeX
20 Mar 2019 News Risky Painkillers Commonly Prescribed for Osteoarthritis
20 Mar 2019 Social Study of 151,305 pts from Clinical Practice Research Datalink, shows that THR/TKR patients exposed to statins for 1-5 years had ~25% reduced risk of arthroplasty revision (HR 0.74 (0.62, 0.88)). https://t.co/AQhKHuAwkD
19 Mar 2019 ACR Video QD Clinic - Goldilocks and Osteoarthritis
18 Mar 2019 Social Nice comprehensive full read review of the Diagnosis and Management of Paget's Disease of Bone in Adults: A Clinical Guideline from the JBMR. https://t.co/Eh9xfPJ2B0
15 Mar 2019 Social 2,933 adults >50 yrs went to the ER with a new vertebral fracture (2008-2014) but 98% did not have a DXA in 2yrs before and 1 yr after; and only 7% started OP Rx; In the ensuing 2 yrs, 38% developed another Fx https://t.co/JYYLFawV5z