Monday, 20 Jan 2020


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22 May 2019 Social Fibomyalgia patients who undergo Knee replacements have significantly more complications (OR 1.55), revisions (OR 1.5), mechanical loosening (OR 1.34) & infection (OR 1.33). MDs and FM pts should be made aware of increased postoperative risks.
21 May 2019 Social US Supreme court has rejected lawsuits against Merck & Fosamax over rare atypical femoral Fx and has directed the lower court to reconsider ruling allowing lawsuits against despite the FDA denying Mercks attempt to update the label about fracture risk
17 May 2019 Social Review of Factors Contributing to Functional Outcomes after Knee replacement includes: Weight, pain & smoking (increase post-op complications), pain, infection (2% w/in 1st 90days), post-operative range of motion and (severity of) the OTHER knee.
06 May 2019 News CDC: One in Four US Adults have Arthritis
02 May 2019 Social Osteoarticular involvement with sarcoidosis is uncommon (<13%); in the hands shows a honeycomb/latticework trabecular pattern in metacarpals
25 Apr 2019 News More Studies Needed to Optimize the Use of Osteoporosis Drugs
24 Apr 2019 ACR Video RheumNow Live Preview with Dr. Kenneth Mathis
23 Apr 2019 News NIH Workshop on Unmet Needs in Osteoporosis
22 Apr 2019 Social RCT of 63 knee OA pts - given PBO or 40 g/d freeze-dried blueberry powder x 4 mos. Significant improvement in WOMAC total, Pain scoresand ADL scores in the blueberry group, but no change in TNFα,IL-1β, IL-6, IL-10, IL-13, MMP3, MMP-13, MCP-1 levels.
19 Apr 2019 Social Phase 3 study tanezumab (anti-NGF) 2.5 mg or 5 mgin knee or hip OA find that 5 mg met 2/3 of 3 primary endpoints at 16wks; but the lower dose failed to be superior to NSAIDs in this 1 yr study. Safety outcomes where less favorable w/ tanezumab.
17 Apr 2019 Social Lateral wedge insoles are often used medial knee OA. Study of 63 preselected pts shows a significant pain reduction (vs neutral soles) but mean difference was 0.7 on 0–10 scale; thus benefitting only a minority of pts
16 Apr 2019 News Intraarticular Trans-Capsaicin Effective in Knee OA
16 Apr 2019 News Smoking Not Protective Against Knee OA
16 Apr 2019 Social The price of new osteoporosis drug Evenity (romosuzumab; sclerostin inhibitor) is $1,825/mo. or $21,900/Yr; Just FDA approved for post-menopausal OP at high risk for Fx . Amgen estimates Evenity to be 34-74% lower than Tymlos & Forteo.
15 Apr 2019 Social Metanalysis of 6 studies suggests that metformin use was inversely associated with the risk of fracture (RR 0.82; 95% CI 0.72, 0.93).
10 Apr 2019 News FDA Approves Romosuzumab (Evenity) for High Risk Osteoporosis
09 Apr 2019 Social Data from the Osteoarthritis Initiative (n 4369) shows that fluctuating or persistent Knee pain over 1 yr had an increased risk of cartilage volume loss and structural progression over 4 years (OR 1.62, 95% CI 1.04–2.54)
27 Mar 2019 News Guidelines for Osteoporosis Management in Postmenopausal Women
23 Mar 2019 Social Dr Phil Conaghan on the similarity between OA and PsA #RNL2019
21 Mar 2019 Social A review of OP Guidelines, published in Osteoporosis International, shows only 27 of the 70 guidelines patient Beliefs, Values or Perceptions.