Monday, 20 May 2019


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09 Aug 2018 News Fractures Augment 10 Year Mortality Risks
09 Aug 2018 Social Matched cohort study shows that exposure to NSAIDs, Cox-2, acetaminophen, narcotics or glucosamine (in 3 yrs prior) does not increase the rate of knee replacement in Knee #OA patients
08 Aug 2018 News Early Hip Fracture Surgery Reduces Mortality
06 Aug 2018 News Big Advances for Two Osteoporosis Drugs
01 Aug 2018 Social Study of 6644 hip & femoral fractures found 2.95% were atypical femoral Fx (90 subtrochanter & 106 femoral shaft Fx). Risk factors were osteopenia/osteoporosis, RA, increased ant. & lat. femoral curvatures, & thicker lateral femoral cortex at the shaft
26 Jul 2018 Social 22,289 women in the Melbourne were studied, 1208 1had knee replacement (TKA) for OA; Increased risk of TKA seen in women who were ever pregnant (HR 1.32) or took oral contraceptives (HR 1.25)
24 Jul 2018 Social Study from Norway showd that Osteoporosisin Psoriatic arthritis patients (mean age 52 yrs) is uncommon (6.4%). No associations BMD and disease activity measures.
20 Jul 2018 Social Pfizer & Lilly report on Phase 3 Tanezumab (NGF inhibitor) in 698 Knee or Hip OA pts. At 16wks TNZ yielded significantly better pain, function & the Pt Global (vs PBO). Rapidly progressive OA seen in <1.5% on TNZ; 0 on PBO.
19 Jul 2018 Social 4543 patients followed for mean 8.4 yrs, crude incidence of knee chondrocalcinosis was 3.2 per 1000 PY and whole cumulative incidence of chondrocalcinosis was 2.7%, more with age and higher HbA1C
17 Jul 2018 Social Amgen and UCB have re-filed for FDA approval of osteoporosis drug romosozumab one year after a complete response letter citing CV risks. New data includes 7,180 ph3, 4,093 ph3 and a 245 pt male OP trial.
15 Jul 2018 Social Sytematic review of supplements for osteoarthritis finds (despite poor quality studies) Limited research evidence to recommend the oral use of Boswellia serrata extract and Pycnogenol, curcumin and methylsulfonylmethane
02 Jul 2018 Social Metanalysis of 11 RCTs show that DMARDs and biologics are no better than Placebo in treating symptomatic Osteoarthritis
27 Jun 2018 Social 233,608 statin initiators not shown to increase the risk of hand osteoarthritis when compared 1:10 with non users (from UK Clinical Practice Research Datalink)
21 Jun 2018 Social Metanalysis of 11 RCTs show that DMARDs and biologics are no better than Placebo in treating symptomatic Osteoarthritis
16 Jun 2018 Social RT @DrAiLynTan: Secondary #osteoporosis in systemic mastocytosis! Prevalence ~ 30% Beware in cascade of multiple vertebral #fractures! m…
16 Jun 2018 Social Dr. David Felson shows bone marrow lesions correlate well with pain of osteoarthritis, and may improve either treatment. from #EULAR SP0152
16 Jun 2018 Social Felson shows diastolic BP shows 2x risk of OA from #EULAR SP0152
15 Jun 2018 Social RT @DrAiLynTan: Osteonecrosis of the #jaw & antiresorptive treatments statistics, prevalence & incidence via Roux #EULAR2018 #ONJ #mand…
15 Jun 2018 News Update on Osteoporosis
13 Jun 2018 Social Denosumab (Prolia) was approved by the European commission for use in glucocorticoid induced osteoporosis (GIOP) for use in the EU. Timing is perfect given all the GIOP and SIOP abstracts presenting at #EULAR2018