Friday, 06 Dec 2019

Bone/OP&OA

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04 Jan 2019 Social Finnish followup study of 68,800 hip fracture pts w hip surgery finds 4.6% w/ complications - esp with heavy alcoholism (HR 1.38); Parkinson’s (1.22); osteoarthritis (2.02); rheumatic Dz (1.44); those w/ depression/psychosis, operative delay, prior THR https://t.co/StahnHXRuZ
03 Jan 2019 Social Chronic Urticaria associated with a 23% higher risk of osteoporosis, irrespective of steroid use. Population study from Israel compared 11,944 Chr urticaria w/ 59,829 controls. (HR = 1.23, 95% CI 1.10–1.37, p <0.001) https://t.co/eSq4BPV2J4
03 Jan 2019 News Uncertain Long Term Efficacy in Trials of Knee Osteoarthritis
27 Dec 2018 Social PLEASE- stop trying Plaquenil, DMARDs, biologics in Hand OA - they dont work!!. My best regimen is: simple analgesics (acetaminophen 1950 mg qd) plus 2.5 mg prednisone, hand OT, and painful PIP/DIP immobilization with 2inch Cohesive tape x 14days https://t.co/I6JvgXuAo2
20 Dec 2018 News Zolendronate Protects Against Fracture in Osteopenia
17 Dec 2018 Social Metanalysis of 24 PPI studies, 319,568 hip fracture pts, suggests PPIs associated with a greater risk of hip fracture (RR 1.20, 95% CI 1.14–1.28, p < 0.0001) and may be greater with higher dose (RR 1.30, 95% CI 1.20–1.40, p < 0.0001). https://t.co/nbiEIPRaXg
03 Dec 2018 News Dendrimer Nanocarrier Delivers IGF-1 to Degenerative Cartilage
02 Dec 2018 Social Bisphosphonate safety review — risk of Atypical Femoral Fracture is 1/1000 and risk of osteonecrosis of the jaw is 1/10,000. One-third of IV zolendronic acid pts will have arthralgia/myalgias or flu like sxs. https://t.co/80xBkZlKgn
28 Nov 2018 Social Claims data study from Germany looked at OA of hip or knee in adults > 60 yrs finding 595,754 pts (mean 75 yrs; 70% female) Dx with OA (21.8%); 63% received analgesics, higher with increasing age. PT in 43.1% and 5.3% w/ joint replacement in 2014. https://t.co/shLSlDeO9h
27 Nov 2018 Social Bisphosphonate safety review - risk of Atypical Femoral Fracture is 1/1000 and risk of osteonecrosis of the jaw is 1/10,000. One-third of IV zolendronic acid pts will have arthralgia/myalgias or flu like sxs. https://t.co/80xBkZlKgn
26 Nov 2018 Social Metanalysis shows DMARDs (6 studies) and biologics (5 studies) offer NO clinically significant benefit compared with placebo in Osteoarthritis. https://t.co/fNGVzuNQNo
21 Nov 2018 News Low Risk of Serious Complications with Meniscectomy
19 Nov 2018 Social 80 overweight & obese pts w/ mild to moderate Knee OA Rx in RDBPCT showing garlic 1000 mg/D significantly lowers pain scores, resistin levels (but not TNF). Garlic may work by effects on MMPs, cytokines? shown to lower CRP levels https://t.co/bg5nwzUpJe https://t.co/us0uBLdCau
13 Nov 2018 News Pre-Diabetes Associated Risk for Arthritis, Obesity and Physical Inactivity
05 Nov 2018 News Controversial New Super Opioid Approved by FDA
05 Nov 2018 News Late Breaker: Can Tanezumab Be Revived for OA?
30 Oct 2018 ACR Video Dr. Olga Petryna: Osteoporotic Refractures in Autoimmune Patients
25 Oct 2018 Social RT @WIRheum: MTX for OA of the knee 12 months, 155 pts, endpoint=pain statistically significant improvement, probably not clinically mean…
24 Oct 2018 Social RT @samwhittle: Merkel Year in Review: SPACE trial (JAMA 18) - opioids NOT superior to NSAIDs for function or pain in OA & back pain. #ACR1…
24 Oct 2018 Social RT @DrBhana: Dr. Cush abstract 428 Significant Pain Reduction with Oral Methotrexate in Knee Osteoarthritis; Results from a Randomised Cont…