Friday, 17 Aug 2018

Drug Safety

Datesort ascending Type Title Save
06 Aug 2018 Social MAINRITSAN2 compared fixed dose (q 6 mos) RTX to "tailored" RTX (to CD19, ANCA titers) in 162 AAV (GPA, MPA) pts - BVAS/relapse rates similar betw fixed (17%) vs tailored (10%) (p=0.22) w/ less infusions in the latter (248 vs 381). https://t.co/swFosJvgGp
06 Aug 2018 Social Open label study from India - 60 pts w/ diffuse systemic sclerosis Rx with open label monthly IV CYC 500 mg/m2 or RTX 1000 mg × 2 doses. At 6 months, the FVC and Rodnan skin score improved in RTX, but not CYC, pts. CYC had more toxicity. UNCONTROLLED. https://t.co/9ZqaIw7uM5
26 Jul 2018 Social FDA grants orphan drug status to lenabasum for dermatomyositis https://t.co/moiw3jCqyi
25 Jul 2018 Social Limited data on pregnancy outcomes with tofacitinib exposure encouraging. In RA , 47 women, 44 men exposed, w/ 1 congenital defect. https://t.co/Nti7w4ZscU In UC studies 11 maternal and 14 paternal exposures w/ no congenital malformations https://t.co/qOnzopZkB3
18 Jul 2018 Social CDC warns there is a shortage of the Shingles vaccine SHINGRIX. GSK has stated there are "order limits and shipping delays will continue throughout 2018.” https://t.co/tJb3qaDgtS
17 Jul 2018 Social Great Suggestions from Janet Pope - reduce MTX Rx errors by only prescribing it on their (Pts) preferred day of the week! https://t.co/gvXULBOm23
15 Jul 2018 Social Great Suggestions from Janet Pope - reduce MTX Rx errors by only prescribing it on their (Pts) preferred day of the week! https://t.co/gvXULBOm23
13 Jul 2018 Social Australian Safety update 28 cases of MTX mis-dosing - most taking weekly MTX dose as DAILY dose! AE: pancytopenia, thrombocytopenia, neutropenia, stomatitis, mucosal ulcers, GI effects. @Risk: nonEnglish, confusion w/ Folate,etc https://t.co/axTZWVyU9E
11 Jul 2018 Social Testosterone use in USA tripled from 2001 - 2011, mostly men without clear indication. In late 2013 2 studies reported increased MI & CVA risk associated with testosterone use and since decreased 50%. https://t.co/qpKT5WuLru
09 Jul 2018 Social RT @MattieRheumMD: Once again PBM OBFUSCATION at its best! https://t.co/M8HNbtlqUA
09 Jul 2018 News Hydroxychloroquine Being Over-Dosed with New Guidelines?
09 Jul 2018 Social Pilot study of 23 pre-surgical Dupuytren's patients shows lesional injections of adalimumab reduced myofibroblast fibrotic markers in surgically removed tissues. Grounds for a study - Yes, but not for clinical current use https://t.co/u5rAhkKDmk
04 Jul 2018 Social "Prednisone is the best drug we have, and prednisone is the worst drug we have"- Peter A. Merkel, MD
03 Jul 2018 Social Year in Review. Dan Solomon reviews and shows no cancer risk with Biologics. #ACR17 https://t.co/vIa6gieN4L
03 Jul 2018 Social DMARD Tip: Leflunomide has a 1/2 life of nearly 20days. Once pt improved w/ 20mg/d (~6-12 wks) I switch dosing to once weekly, often less total mg (eg, LEF 4-6 tab q friday (80-120mg/wk). Monitoring and risks are same. https://t.co/IDd1UaCbp7
03 Jul 2018 Social Risk factors for retinal toxicity associated with hydroxychloroquine include longer duration of HCQ use [adj OR 4.71], higher daily dose (3.34), presence of kidney disease (8.56) https://t.co/OrN99DD2k1
03 Jul 2018 Social Metanalysis of checkpoint inhibitor (nivolumab, pembrolizumab or atezolizumab)shows high rates of hypothyroidism (OR 7.6), pneumonitis (5.4), colitis (2.9), hypophysitis (3.4), rash (2.4), fatigue (32%), diarrhea (19%) &> 20% w/ arthraligia or back pain. https://t.co/zdH0A0GEPs
30 Jun 2018 Social The RheumNow Week in Review is up! Life Savers for Rheumatologists - on vaccinations, Bactrim prophylaxis & the downside of Febuxostat. https://t.co/Jn8vv8ZJIz Check out the podcast on iTunes, Stitcher, https://t.co/ly5ZMFV2mn https://t.co/IMPwCFurbE
27 Jun 2018 Social TMP/SMX prophylaxis following rituximab in ANCA+ associated vasculitis reduces infections by 70% (HR 0.30) - 192 AAV pts with 92 infx in 49 pts (only 1 due to PJP). https://t.co/VmVDXQqlSZ
22 Jun 2018 Social RT @ACRheum: The ACR believes that safe and effective treatments should be accessible to all patients at the lowest possible cost. https://…