Monday, 20 Jan 2020

Drug Safety

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09 Jan 2020 Social Dr. Heidi Jacobi #UTSW lecturing on PSS. Other options for refractory dz include IVIG, RTX, TCZ, ABA and uVA1 therapy
08 Jan 2020 Social Misuse and abuse of Gabapentin in US? Between 2003-2016 there were 260 million gabapentinoid visits. Annual use nearly quadrupled from 2003 to 2016 (mostly PCPs 46%). Nearly half w/ concurrent opioids (32.9%) or benzodiazepines (15.3%).
05 Jan 2020 Social 2019 YEAR IN REVIEW Podcast is up! Superheros, women, New Drugs, Novel Approaches, Failed drugs, MTX, Who's killing medicine & low dose pred Watch here>> or Podcast Listen on iTunes or Soundcloud >>
01 Jan 2020 Social A review of 376 FDA advisory panels between 2008-15, finds that 22% of FDA’s final actions were discordant with an advisory panels recommendations (moreso w/ safety panels). Of these, 3/4 lead to more restrictive actions and 1/4 less restrictive decisions
01 Jan 2020 News Best of 2019 - Biologic Safety Guidelines from the British Society for Rheumatology
31 Dec 2019 Social CBD isn't entirely safe. Forbes reviews evidence of hepatotoxicity, esp with the CBD-based epilepsy drug Epidiolex; in studies 5-20% had liver issues. FDA has also warned of suicidal ideation, agitation, suicide, depression, aggression & panic attacks
31 Dec 2019 Social RTX product label list these postmarketing AEs (not seen in trials) - uveitis, optic neuritis, systemic vasculitis, pleuritis, lupus-like syndrome, serum sickness, polyarticular arthritis, and vasculitis with rash.
30 Dec 2019 Social FDA has approved Otezla 30 mg bid for adults with oral ulcers associated with Behcet's Disease; based on the results showing apremilast lowers the number and pain of oral ulcers in a 12-week placebo-controlled Phase 3 study.
30 Dec 2019 News Best of 2019 - Methotrexate and the Risk of Lung Disease
30 Dec 2019 Social I would never allow my patient to self medicate or regulate their Prednisone or MTX, immunosuppresives or biologics. It's what they don't know that will hurt them.
28 Dec 2019 Social RT @NYTHealth: Patients and insurance companies in the United States pay higher prices for medications, imaging tests, basic health visits…
24 Dec 2019 Slide of the day Injection Site Reactions
23 Dec 2019 Social FDA has approved a new sleep drug, Dayvigo, 5 mg and 10 mg, based on two late-stage placeboe controlled studies for insomnia. Use for 1-6 months, to be classified as a controlled substance because it can be addictive and has the potential to be abused
20 Dec 2019 Social Gabapentin and baclofen use, misuse, toxicity, & suicide attempts increased in the United States since 2013. Gabapentin use increased 72% and baclofen increased 37% from 2014 to 2017.
16 Dec 2019 News No Cancer Risk with Systemic Necrotizing Vasculitis
12 Dec 2019 Social Abarca, a pharmacy benefits manager, reports Amgen has agreed to give its health insurer clients an additional discount (amount$$??) on Enbrel, if patients discontinue taking it after three months - to help health insurers save costs if pts d/c Enbrel
12 Dec 2019 Social American College of Cardiology review of Colchicine (biology, hx, pharmacology, use) in the treatment of pericardial disease (acute/chronic/recurrent pericarditis, pericardial effusion, Post-cardiac Injury Syndrome). Full read review available.
09 Dec 2019 Social TB is highly endemic in S. Africa - S. African registry reports 97 TB cases in biologic users w/ TB rate 1240/100000 PYs vs zero in biologic naive pts. 1/3 were extra-pulmonary. TB risk highest w/ TNFi Mabs (1683) vs 861 ETN or 681 other MOAs.
08 Dec 2019 Social The RheumNow Podcast is up! Monitoring Methotrexate Safety, Palmoplantar pustulosis, diet in SLE, enthesitis Rx, & benefits of smoking cessation..... Listen here>>
06 Dec 2019 Social ACR MTX monitoring guidelines from 1994 (Alarcon et al) -pts should be screened for HBV, HCV, Alb. At AST, ALT should be checked at intervals of every 4-8 weeks. MTX should be stopped/adjusted or liver Bx if AST abnl in 5 of 9 (or 6/12) in 12 mos.