Wednesday, 16 Oct 2019

Drug Safety

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25 Apr 2019 Social Danish study of 92 355 adults compared Fx rates between new users of denosumab (DEN) or alendronate - finds no advantage for DEN for hip Fx (aHR 1.08; 0.92-1.28) or any Fx (aHR 0.92; 0.83-1.02). Data doesnt support preference for DEN in high risk pts. https://t.co/dpyRF9VxH6
24 Apr 2019 Social Metanalysis shows NSAIDS increase rates of delayed union or nonunion (OR 2.07; 1.19 to 3.61) in adults with fracture, osteotomy, fusion surgery; but not in pediatrics (OR 0.58) or with low dose/short duration NSAID exposure (OR 1.68). https://t.co/0tM8OFLhzt
23 Apr 2019 Social Do you use PJP prophylaxis w/ Bactrim in RA pts? 2640 RA pts found only 19 cases of pneumocystis pneumonia. Risk factors were high dose MTX (OR 4.5), >65 yrs (OR 3.7), ≥2 ISPs (3.7), prednisolone ≥5 (OR 12.4) - a combo of these has a 2.3-5.8% riskof PJP. https://t.co/5Pf2FskE30
22 Apr 2019 Slide of the day Vaccination Deficit in Rheumatology
12 Apr 2019 News Update on Vaccines in Autoimmune Patients
11 Apr 2019 Social 36 studies of 6662 depression patients shows the addition of antiinflammatory drugs (NSAIDs, steriods, statins, cytokine inhib, minocycline) improved antidepressant effects in Major Depression pts without increasing the risk of side‐effects. https://t.co/RdRNtVCfjh
11 Apr 2019 Social MMWR reports that for the 8th yr in a row the US TB rate dropped 1.3% to 2.8 per 100,000. In 2018 there were 9029 TB cases (69% in non–U.S.-born). TB risk in non-US born was >14 times that of U.S.-born persons. https://t.co/qdzvyavNVX
10 Apr 2019 ACR Video RheumNow Live Preview with Dr. Len Calabrese
09 Apr 2019 Social 151 pts w/ myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) were treated with either rituximab or PBO showing no effect of RTX!! Really? someone, somewhere believes ME/CFS or FM is an immunologic dz? Do NOT use biologics, DMARDS in such pts. https://t.co/1xXG94QEnP
08 Apr 2019 Social Long term safety study of 4481 tofacitinib pts w/ 9.5yrs exposure (16,291PYs). 52% discontinued Rx (4% insufficient response; 24% adverse events). AE incidence rates were 3.4/100PY for H zoster, 2.4/100Py SIE, 0.8 cancer, 0.4 MACE, 0.3 Mortality. https://t.co/Qv5keuKXr3
04 Apr 2019 Social RT @MattieRheumMD: NSAIDS can reduce fertility in women - from Dr Sammaritano. #RNL2019
03 Apr 2019 Social RT @RheumNow: #RNL2019 Dr Carol Langford discusses when to use RTX vs CTX in GPA https://t.co/w0vWVrf7JX
01 Apr 2019 News RheumNowLive On Demand: Infection Prevention and Management with Newer Agents - Jack Cush, MD
28 Mar 2019 Social Claims data analysis of 11,248 matched patients starting abatacept or TNFi showed the risk of hospitalized infection was 37 ABA vs 47 TNFi (HR 0.78; 95% CI 0.64-0.95). Thus ABA was associated with a 22% less risk any hospitalized infection. https://t.co/Ij6b0IYcAZ
27 Mar 2019 Social QD Clinic - Medication Reminders | RheumNow -Measures taken to remind or ensure medication compliance https://t.co/7xnuGPeFxI
27 Mar 2019 News Acute Problems Associated With Cannabis Use
25 Mar 2019 Social In newly Dx GPA it’s ok to treat with steroids PLUS MTX or MMF or RTX. #RNL2019 Dr Carol Langford https://t.co/rihhR6x7u3
25 Mar 2019 Social #RNL2019 Dr Carol Langford discusses when to use RTX vs CTX in GPA https://t.co/w0vWVrf7JX
25 Mar 2019 Social After either RTX or CTX induction, 102 pts w/ ANCA-associated vasculitis were give maintenance w/ azathioprine plus belimumab or placebo. Belimumab did not reduce the flare rate (HR=1.07;) or relapse (HR=0.88) (NS) in these patients https://t.co/5EgdzRRXq8
18 Mar 2019 Social QD Clinic - When To Stop MTX- Should/Can a Patient ever stop MTX? | RheumNow https://t.co/z0Dhwdbr3Q