Tuesday, 19 Nov 2019

Drug Safety

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13 Jul 2016 Social German RABBIT registry study >13K pts shows incr. risk of lower GI perforations w/ Actemra (2.7/1000PY);1/4 pts died https://t.co/u9A4TRFMso
05 Aug 2017 Social Dr. Cush reviews FDA on sirukumab & tofacitinib and other news from the past week on https://t.co/V10S4oVFsv https://t.co/1EBh6uYTDI
13 Nov 2019 Social RT @Janetbirdope: Do you combine bDMARD with apremilast? #ACR #ACR19 @RheumNow abstract 1481
26 Feb 2018 Social Of 134 RTX treated pts (mean 79 mos), 23 (17%) developed Hypogammaglobulinemia after a mean 64 mos & assoc w/ 4x risk of severe infections. Gammaglobulin <8 g/L at baseline was a predictor of hypogamma (HR 7.34), but MTX was protective (HR 0.26) https://t.co/AMOtNAUeXR
25 Jul 2018 Social Limited data on pregnancy outcomes with tofacitinib exposure encouraging. In RA , 47 women, 44 men exposed, w/ 1 congenital defect. https://t.co/Nti7w4ZscU In UC studies 11 maternal and 14 paternal exposures w/ no congenital malformations https://t.co/qOnzopZkB3
05 Jun 2019 Social CDC has updated its recommendations for TB testing of health care personnel. All HCP should be tested initially but after TB risk assessment, there is no need for routine or serial TB testing in the absence of exposure or ongoing risk of TB. https://t.co/qtAdz8d7OK
14 Sep 2017 Social No difference in folic acid low dose vs high dose use with regard to hepatotoxicity of MTX. https://t.co/fnqqqwyE23
01 May 2015 Social Necrotizing aspergillosis reviewed. CTD (RA,AS) @risk. Dx by A. fumigatus IgG Abs & upper lobe cavitary lesions http://buff.ly/1IdaanE 
14 Mar 2017 Social VA study 748 RA pts w/ HCV, ALT incr only in 3.4%; Hepatotoxicity more common w/ Biologic than cDMARD(4.8 v 2.3%) https://t.co/KSHXUdVAai
23 Mar 2016 Social Statin use is assoc. w/ a 21% increased risk of skin cancer (NMSC) - data from >130K postmenopausal women (WHI) https://t.co/2uxJOC719Y
14 Oct 2015 Social Plaquenil retinopathy is rare; risk incr w/ doses >6.5 mg/kg/d, total >1000g, Rx for >5 yrs, CKD, liver dz, elderly http://t.co/Dch3tqKb12
18 Aug 2016 Social Great rheumatology primer on sorting out tropical mosquito related viruses from @LCalabreseDO & CCF https://t.co/j4AdfSQX7P
08 Sep 2018 Social RheumNow Week in Review is up! This week the sunshine folder & ugly tie rack! Watch the video here https://t.co/Lb0mFGPTHc or try the podcast on iTunes in your car or on Android Auto in your car on Stitcher or https://t.co/Lb0mFGPTHc
16 Feb 2019 Social Dr Anne Stevens. Other arc options for localized scleroderma include tocilizumab and abatacept. #RWCS2019 https://t.co/AIfARTZ3CD
18 Jul 2019 Social anti-MDA5+ amyopathic dermatomyositis (ADM) with ILD is severe and refractory. NEJM letter reports on 18 ADM Rx w/ tofacitinibs who showed better 6 mo survival (100% vs 78%) (P=0.04) and improved ferritin, FVC, DLCO, & CT Chest over time. https://t.co/lsVGPxChoO
03 Oct 2017 Social `07 JIA pts followed for 3 yrs on Biologics- 25% (35) had Serious/Opportunistic infx. range 10.6-14.8/100py https://t.co/8kad5PmLKR
11 Nov 2017 Social RT @NYTHealth: Fentanyl, not heroin, drove 2016 surge in drug-overdose deaths, C.D.C. says. https://t.co/5LH0z5rtcz
05 May 2016 Social BMJ study shows >250,000 deaths/Yr in US due to medical errors – making it the 3rd leading cause of death https://t.co/IviNCTvaaL
12 Apr 2017 Social NY Times article on "deprescribing" and polypharmacy - 1/3 hosp involve a drug AE, 400,000 preventable drug AE/year https://t.co/XyPnjbmC4e
15 Nov 2015 Social Periprosthetic Joint infx: obesity, malnurish, diabetes, RA, anemia, CV dz, CRF, smoking, EtOH abuse, depression https://t.co/yVaSMkQIUX