Wednesday, 28 Jun 2017

Drug Safety

Date Typesort ascending Title Save
30 Jun 2016 Social Adherence to MTX 10-20% less than expected in CORRONA CERTAIN study- found 8.3% D/C MTX & 11.4% missed >=1 dose/mo https://t.co/EDjqkrgIRz
06 May 2017 Social FDA Guide to Drug Safety. Black Box Warning; appears on drugs label to alert of serious or life-threatening risks https://t.co/1gNk2RB5C0
14 Aug 2015 Social Do you have the means of formal clinical med reviews w/ pharmacist? They can improve adherence, compliance, outcomes http://t.co/HgShWp94Gp
14 Feb 2017 Social Do HBV testing with TCZ! Study shows HBV reactivation w/ tocilizumab Rx only with Chronic HBV, not Resolved HBV https://t.co/NZQXQ8xWHB
20 Jun 2015 Social Drug Safety Bulletin: EULAR 2015 Safety Reports @RheumNow, TNFi and Biologics lower risk of Sepsis & death after SIE http://t.co/aMu1hNXR0K
13 Jul 2016 Social German RABBIT registry study >13K pts shows incr. risk of lower GI perforations w/ Actemra (2.7/1000PY);1/4 pts died https://t.co/u9A4TRFMso
14 Mar 2017 Social VA study 748 RA pts w/ HCV, ALT incr only in 3.4%; Hepatotoxicity more common w/ Biologic than cDMARD(4.8 v 2.3%) https://t.co/KSHXUdVAai
23 Mar 2016 Social Statin use is assoc. w/ a 21% increased risk of skin cancer (NMSC) - data from >130K postmenopausal women (WHI) https://t.co/2uxJOC719Y
18 Aug 2016 Social Great rheumatology primer on sorting out tropical mosquito related viruses from @LCalabreseDO & CCF https://t.co/j4AdfSQX7P
14 Oct 2015 Social Plaquenil retinopathy is rare; risk incr w/ doses >6.5 mg/kg/d, total >1000g, Rx for >5 yrs, CKD, liver dz, elderly http://t.co/Dch3tqKb12
05 May 2016 Social BMJ study shows >250,000 deaths/Yr in US due to medical errors – making it the 3rd leading cause of death https://t.co/IviNCTvaaL
12 Apr 2017 Social NY Times article on "deprescribing" and polypharmacy - 1/3 hosp involve a drug AE, 400,000 preventable drug AE/year https://t.co/XyPnjbmC4e
02 Dec 2016 Social J&J/Dupuy hit with $1billion verdict to 6 plantiffs who recv metal on metal THR; appeal planned w/ >8000 more suits https://t.co/OBuirKGvO7
01 May 2015 Social Necrotizing aspergillosis reviewed. CTD (RA,AS) @risk. Dx by A. fumigatus IgG Abs & upper lobe cavitary lesions http://buff.ly/1IdaanE 
15 Nov 2015 Social Periprosthetic Joint infx: obesity, malnurish, diabetes, RA, anemia, CV dz, CRF, smoking, EtOH abuse, depression https://t.co/yVaSMkQIUX
07 Jun 2016 Social Spanish pts on TNFi note 2 fold higher SAE/mortality risk in RA than PsA; w/ more infx, CVS, Pulm, Infusion AE in RA https://t.co/ltcErtY64p
01 Oct 2016 Social Rates of Septic arthritis increased 43% in UK (5.5-->7.8/100k) over last 15yrs, especially in elderly >75. https://t.co/Ol5ZSZu7bb
29 Apr 2017 Social #SOTA2017 Dr. Bingham Most common joints are large - knees ankels shoulders, many w/ Small - MCPs PIPs wrists, ReA in 2 pts
23 Jan 2017 Social Study of 565k people shows chronic PPI has a nearly 2 fold risk of C. dificile & 4 fold risk of campylobacter infxn https://t.co/3pik6fmEMc
25 May 2015 Social 10,763 AS pts from Taiwan showed long-term Cox2 or NSAIDs had fewer CV events & short term NSAIDs had incr CV events http://t.co/215iU29t1K