Tuesday, 25 Sep 2018

Drug Safety

Date Typesort ascending Title Save
14 Oct 2015 Social Plaquenil retinopathy is rare; risk incr w/ doses >6.5 mg/kg/d, total >1000g, Rx for >5 yrs, CKD, liver dz, elderly http://t.co/Dch3tqKb12
02 Dec 2016 Social J&J/Dupuy hit with $1billion verdict to 6 plantiffs who recv metal on metal THR; appeal planned w/ >8000 more suits https://t.co/OBuirKGvO7
03 Oct 2017 Social `07 JIA pts followed for 3 yrs on Biologics- 25% (35) had Serious/Opportunistic infx. range 10.6-14.8/100py https://t.co/8kad5PmLKR
04 Jan 2018 Social RT @DrAiLynTan: "Medicine used to be simple, ineffective & relatively safe It is now complex, effective & potentially dangerous" Cyril Cha…
01 Oct 2016 Social Rates of Septic arthritis increased 43% in UK (5.5-->7.8/100k) over last 15yrs, especially in elderly >75. https://t.co/Ol5ZSZu7bb
25 Jul 2018 Social Limited data on pregnancy outcomes with tofacitinib exposure encouraging. In RA , 47 women, 44 men exposed, w/ 1 congenital defect. https://t.co/Nti7w4ZscU In UC studies 11 maternal and 14 paternal exposures w/ no congenital malformations https://t.co/qOnzopZkB3
15 Nov 2015 Social Periprosthetic Joint infx: obesity, malnurish, diabetes, RA, anemia, CV dz, CRF, smoking, EtOH abuse, depression https://t.co/yVaSMkQIUX
20 Oct 2017 Social U-ACT shows early TCZ (+/- MTX) is superior to MTX alone at sustained remission >6 most Iin very early RA patients https://t.co/qSK9Hslgie
01 May 2015 Social Necrotizing aspergillosis reviewed. CTD (RA,AS) @risk. Dx by A. fumigatus IgG Abs & upper lobe cavitary lesions http://buff.ly/1IdaanE 
27 Jan 2018 Social RheumNow Wk in Review is up. Discussing MPO bronchiectasis, $$ biologics, comorbidity in myositis, secondary TNF failure & ADAbs. Listen here https://t.co/ti9vRQrNaE Watch there https://t.co/TnC5Jg5knN
11 Nov 2017 Social RT @NYTHealth: Fentanyl, not heroin, drove 2016 surge in drug-overdose deaths, C.D.C. says. https://t.co/5LH0z5rtcz
30 Jun 2016 Social Adherence to MTX 10-20% less than expected in CORRONA CERTAIN study- found 8.3% D/C MTX & 11.4% missed >=1 dose/mo https://t.co/EDjqkrgIRz
12 Apr 2017 Social NY Times article on "deprescribing" and polypharmacy - 1/3 hosp involve a drug AE, 400,000 preventable drug AE/year https://t.co/XyPnjbmC4e
08 Sep 2018 Social RheumNow Week in Review is up! This week the sunshine folder & ugly tie rack! Watch the video here https://t.co/Lb0mFGPTHc or try the podcast on iTunes in your car or on Android Auto in your car on Stitcher or https://t.co/Lb0mFGPTHc
23 Mar 2016 Social Statin use is assoc. w/ a 21% increased risk of skin cancer (NMSC) - data from >130K postmenopausal women (WHI) https://t.co/2uxJOC719Y
14 Feb 2017 Social Do HBV testing with TCZ! Study shows HBV reactivation w/ tocilizumab Rx only with Chronic HBV, not Resolved HBV https://t.co/NZQXQ8xWHB
05 Nov 2017 Social RT @philipcrobinson: MTX does nothing in GCA. It is so sad I really really want a steroid sparing agent to work in GCA. Bring on toci #ACR1…
26 Feb 2018 Social Of 134 RTX treated pts (mean 79 mos), 23 (17%) developed Hypogammaglobulinemia after a mean 64 mos & assoc w/ 4x risk of severe infections. Gammaglobulin <8 g/L at baseline was a predictor of hypogamma (HR 7.34), but MTX was protective (HR 0.26) https://t.co/AMOtNAUeXR
14 Dec 2017 Social NICE and NHS reject the approval of Tocilizumab for use in GCA citing cost concerns https://t.co/TZMmnj91sp https://t.co/aQMFLKVCYo
13 Jul 2016 Social German RABBIT registry study >13K pts shows incr. risk of lower GI perforations w/ Actemra (2.7/1000PY);1/4 pts died https://t.co/u9A4TRFMso