Wednesday, 16 Oct 2019

Drug Safety

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04 Feb 2018 Social Risk factors for retinal toxicity associated with hydroxychloroquine include longer duration of HCQ use [adj OR 4.71], higher daily dose (3.34), presence of kidney disease (8.56) https://t.co/p8M4ezWLvG.
03 Jul 2018 Social Metanalysis of checkpoint inhibitor (nivolumab, pembrolizumab or atezolizumab)shows high rates of hypothyroidism (OR 7.6), pneumonitis (5.4), colitis (2.9), hypophysitis (3.4), rash (2.4), fatigue (32%), diarrhea (19%) &> 20% w/ arthraligia or back pain. https://t.co/zdH0A0GEPs
26 Nov 2018 Social Could routine use of hydroxychloroquine reduce the rate of serious infections in immunosuppressed patients? A modest to moderate risk reduction noted in two large SLE cohort studies. https://t.co/pssLrteRRq
06 May 2019 Social The RheumNow Podcast is up – DESIREABLE Results (5.3.19) WATCH it here https://t.co/uyYKxw21Kd or listen to the PODCAST on iTunes (Apple Car Play) or SoundCloud here>> https://t.co/HW0aDJo90Q
05 Jul 2016 Social @RonanTKavanagh Jury still out. ACR says DMARDs or RTX but pts on RTX or TNFi can get melanoma. I would use best biologic avail. & avoid TNF
06 Oct 2017 Social 2016 US Top selling drugs: Humira $13.6 billion, Enbrel $7.4 billion, Remicade $5.3 billion, Lyrica $4.4B,RTX $3.9B https://t.co/FZM2Vow44n
15 Nov 2017 Social FDA issues a Safety Alert over FEBUXOSTAT and increased risk of Cardiac Death (compared to allopurinol users). This… https://t.co/3clsintj7L
05 Mar 2018 Social Rituximab associated adverse events are more common in treating lymphoma/leukemi ( 25-36%) than with autoimmune dz (9-17%) and are more common with splenomegaly, anemia, hx of allergies, age. https://t.co/gUREPFvbUb
06 Aug 2018 Social MAINRITSAN2 compared fixed dose (q 6 mos) RTX to "tailored" RTX (to CD19, ANCA titers) in 162 AAV (GPA, MPA) pts - BVAS/relapse rates similar betw fixed (17%) vs tailored (10%) (p=0.22) w/ less infusions in the latter (248 vs 381). https://t.co/swFosJvgGp
08 Jan 2019 Social QD Video from RheumNow - Dicusssion of statins and myalgias/arthralgias. https://t.co/zKFZEF6MiL
17 Jun 2019 Social RT @tuna0sashimi: Please please publish this so we can quote it for our patients RT @CreakyJoints: Reassuring news about hair loss and meth…
27 Jul 2016 Social FDA warns against using fluoroquinolones (to Rx UTI, bronchitis etc) if other safer Rx options exist. https://t.co/UA0uNmcW3O
09 Aug 2017 Social "Prednisone is the best drug we have, and prednisone is the worst drug we have"- Peter A. Merkel, MD
20 Oct 2017 Social At #APLAR2017 I taught how to manage post-MTX related CNS toxicity "the blahs" with weekly dextromethorphan 20-50mg given w MTX & day after
17 Dec 2017 Social Sanofi recalls SYNVISC-One, specifically one batch of ~12,000 plus distributed between Oct. 25 -Nov. 7, 2017 only in the USA https://t.co/3f4ocIoEEl
12 Apr 2018 Social In early arthritis clinics in Leeds and UK ERAS study (454 &895 pts), DMARD free remission seen in 15-9.4%; predictors included acute onset, short Sx duration, NO smoking, No Xray damage, Seronegativity, absent HLA shared epitope alleles https://t.co/3yulHyrS4O
17 Sep 2018 Social NSAID-exacerbated respiratory disease occurs in 1/10 pts with asthma and rhinosinusitis- There are new expert guidelines on recognition, management, high morbidity and mortality risks. https://t.co/kY1RYSizqz
24 Feb 2019 Social QD Clinic Week 6 Podcast - case based lessons from the real world. Discusion of Pregnancy Rules, Optimizing MTX, Changing DMARDs, Stopping Anakinra in Still's, NP decisions. Listen on iTUNES or Here https://t.co/61KO2jKxJp
22 Aug 2016 Social Patients receiving IL-1 inhibitors (anakinra) may be at higher risk for Streptococcus infections. https://t.co/rXaUQKHlFZ
13 Jan 2017 Social ARTIS & DANBIO registries: SpA(AS, PsA) TNFI Rx does NOT increase risk of cancer overall, nor 6 most common types CA https://t.co/vjQ1SJ3olk