Friday, 18 Oct 2019

Drug Safety

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04 Jan 2018 Social Study of ~300k Canadian pregnancies (1998-2015) finds 51 1st Trimester exposures to Arava & 21 w/ 2nd/3rd Tri exposure; no incr risk of spont Abortion (11), Malformations (5), prematurity (7) or LBW (8)
01 Jun 2018 Social NSAIDs may reduce risk of certain cancers, esp colorectal CA. But NSAIDs combined with phosphatidylcholine is superior to NSAIDs alone in animal models at preventing colon cancer
24 Oct 2018 Social RT @CCalabreseDO: incidence of hypogam with rituximab is low but progressively identified overtime. infection rates remain low. abstract #2…
29 Sep 2019 Social The RheumNow Podcast is up - Watch it here>> or listen to the podcast on iTunes, or SoundCloud>>
14 Jul 2015 Social Drug Safety DONTs:1) use anothers pills; 2) change dosingt; 3) crush tablets; 4) ignore expire date; 5) store in heat
24 May 2017 Social Claims data on 2495 JIA pts shows significantly more serious bacterial infx w/ TNFi use (HR 2.72) compared to DMARDs
20 Mar 2017 Social IBD may be a rare complication of systemic JIA treated with IL-1 inhibitors - 3/81 cases ID by retrospective review
25 Aug 2017 Social RheumNow Wk in Review is up! Or do the podcast on iTunes or here - give us a good review!
06 Nov 2017 Social RT @psufka: No difference in outcomes compared to baseline for pts exposed to certolizumab during 1st tri of pregnancy #ACR17 @rheumnow #13…
09 Jan 2018 Social Gabapentinoid use steadily rose from 1.2% of adults in 2002 to 3.9% in 2015
15 Jun 2018 Social RT @pkiely500: #EULAR2018 Relative risk of post surgical infections in bDMARD users finds no difference between MOA but picks up co-prescri…
25 Oct 2018 Social RT @psufka: Even low dose prednisone (5mg/day) associated with increased cumulative risk of infection #ACR18 @rheumnow…
08 Apr 2019 Social Long term safety study of 4481 tofacitinib pts w/ 9.5yrs exposure (16,291PYs). 52% discontinued Rx (4% insufficient response; 24% adverse events). AE incidence rates were 3.4/100PY for H zoster, 2.4/100Py SIE, 0.8 cancer, 0.4 MACE, 0.3 Mortality.
25 Oct 2015 Social RT @LCalabreseDO: ACIP approves updates to 2016 adult immunization schedule - Rheumatologists need to know!! @Rheu…
30 Jan 2016 Social @RonanTKavanagh Very large 683 cohort only showed NS trend. Probs? 1) mixed RA w/ PsA/IBD; 2) unable to adjust for Dz activity,Age, comorb.
27 Oct 2016 Social Hydroxychloroquine hearing loss/ototoxicity - a rare complication that I did not know about!
19 Sep 2016 Social In Spain, after a neg PPD, in 1st 1-2 yrs on TNFI theres a 4.3% seroconvert w/ repeat PPD, thought to be LTBI
12 Aug 2015 Social Leflunomide (Arava) shortages driving you crazy? Access and options covered at RheumNow
14 Aug 2017 Social Study shows etanercept may be stored at conditions of 25°C±2°C (77F) for up to 1 month within expiry dates
18 Feb 2016 Social Opioid Use Increases the Risk of Hospitalized Infections in Rheumatoid Arthritis patients.