Friday, 19 Oct 2018

Drug Safety

Datesort ascending Type Title Save
27 Aug 2018 Social FDA info on insulin use during disaster/hurricaine applies well to biologic use - "...that insulin be stored...~36°F to 46°F" until use... but "may be left unrefrigerated at 59°F to 86°F for up to 28 days and continue to work" Avoid extremes in temp! https://t.co/gyxbhDdxVt
26 Aug 2018 Slide of the day Avoiding Teratogens in Pregnancy
25 Aug 2018 Social @CCalabreseDO @HealioRheum I STRONGLY disagree. The FDA, CDC and ETN, ADA & Infliximab worked this out long ago with Package insert language for LTBI saying "anti-TB therapy must be started BEFORE the TNF inhibitor" Specifically they meant give 300 mg INH, then give TNFi. "2-8wks" has no scientific basis
25 Aug 2018 Social @RajkiranDudam @psufka @PatelAarat @RheumRegistrar @RheumJC @shikhsingla @rajsengupta @MedReuma Easy. Lower MTX dose. Folate every day may help. In my experience vitamin A 8000 IU qd helps w/ nausea and oral ulcers much moreso than playing with folate use. https://t.co/Lryb3KAaWC
24 Aug 2018 Social RT @RheumNow: Which Anti-Rheumatic is shown/known to be a clear teratogen and thus pregnancy must be prevented/avoided when taking this dru…
23 Aug 2018 Social Which Anti-Rheumatic is shown/known to be a clear teratogen and thus pregnancy must be prevented/avoided when taking this drug?
22 Aug 2018 Social Systematic review show that adherence and persistence on etanercept and adalimumab are quite low, often 50% or less, somewhat better w/ infliximab. How to improve? Supervised injectables or infusions, pt education, drug levels? https://t.co/7tP8zmDr4R
20 Aug 2018 News Health Secretary Azar Eyes Rebate Reform
06 Aug 2018 Social MAINRITSAN2 compared fixed dose (q 6 mos) RTX to "tailored" RTX (to CD19, ANCA titers) in 162 AAV (GPA, MPA) pts - BVAS/relapse rates similar betw fixed (17%) vs tailored (10%) (p=0.22) w/ less infusions in the latter (248 vs 381). https://t.co/swFosJvgGp
06 Aug 2018 Social Open label study from India - 60 pts w/ diffuse systemic sclerosis Rx with open label monthly IV CYC 500 mg/m2 or RTX 1000 mg × 2 doses. At 6 months, the FVC and Rodnan skin score improved in RTX, but not CYC, pts. CYC had more toxicity. UNCONTROLLED. https://t.co/9ZqaIw7uM5
26 Jul 2018 Social FDA grants orphan drug status to lenabasum for dermatomyositis https://t.co/moiw3jCqyi
25 Jul 2018 Social Limited data on pregnancy outcomes with tofacitinib exposure encouraging. In RA , 47 women, 44 men exposed, w/ 1 congenital defect. https://t.co/Nti7w4ZscU In UC studies 11 maternal and 14 paternal exposures w/ no congenital malformations https://t.co/qOnzopZkB3
18 Jul 2018 Social CDC warns there is a shortage of the Shingles vaccine SHINGRIX. GSK has stated there are "order limits and shipping delays will continue throughout 2018.” https://t.co/tJb3qaDgtS
17 Jul 2018 Social Great Suggestions from Janet Pope - reduce MTX Rx errors by only prescribing it on their (Pts) preferred day of the week! https://t.co/gvXULBOm23
15 Jul 2018 Social Great Suggestions from Janet Pope - reduce MTX Rx errors by only prescribing it on their (Pts) preferred day of the week! https://t.co/gvXULBOm23
13 Jul 2018 Social Australian Safety update 28 cases of MTX mis-dosing - most taking weekly MTX dose as DAILY dose! AE: pancytopenia, thrombocytopenia, neutropenia, stomatitis, mucosal ulcers, GI effects. @Risk: nonEnglish, confusion w/ Folate,etc https://t.co/axTZWVyU9E
11 Jul 2018 Social Testosterone use in USA tripled from 2001 - 2011, mostly men without clear indication. In late 2013 2 studies reported increased MI & CVA risk associated with testosterone use and since decreased 50%. https://t.co/qpKT5WuLru
09 Jul 2018 Social RT @MattieRheumMD: Once again PBM OBFUSCATION at its best! https://t.co/M8HNbtlqUA
09 Jul 2018 News Hydroxychloroquine Being Over-Dosed with New Guidelines?
09 Jul 2018 Social Pilot study of 23 pre-surgical Dupuytren's patients shows lesional injections of adalimumab reduced myofibroblast fibrotic markers in surgically removed tissues. Grounds for a study - Yes, but not for clinical current use https://t.co/u5rAhkKDmk