Monday, 10 Dec 2018

Drug Safety

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25 Oct 2018 Social RT @synovialjoints: Case reports prompted prospective trial from Tsuji H showing evidence of combined high dose GC + TAC + CYC beneficial i…
24 Oct 2018 Social RT @ArthurRheum: Bimekizimab phase 2 presented at #ACR18 with extremely impressive results for joints and skin improvement (in fact the pri…
24 Oct 2018 Social RT @ELittlejohnDO: Common patient concern: Humira and pregnancy. IgG does not cross the placenta until 12-15 weeks. Consider discontinuing…
24 Oct 2018 Social RT @DrBhana: Dr. Cush ABSTRACT 898 Efficacy and Safety of Tocilizumab for the Treatment of Systemic Sclerosis: Results from a Phase 3 Rando…
24 Oct 2018 Social RT @NicoleBitencou5: #Plaquenil related #hyperpigmentation can occur soon after starting tx even though usually associated with long term u…
24 Oct 2018 Social RT @CCalabreseDO: incidence of hypogam with rituximab is low but progressively identified overtime. infection rates remain low. abstract #2…
23 Oct 2018 Social RT @MissbeeMD: "We conditionally recommend against methotrexate in breastfeeding women." "We strongly recommend that TNF-inhibitors as a c…
23 Oct 2018 Social RT @KDAO2011: For joint replacement surgery, how long do you hold tofacitinib?
23 Oct 2018 Social RT @ArthurRheum: Japanese data show adding a biologic did not increase risk of solid cancers... small numbers though @RheumNow #ACR18 https…
23 Oct 2018 Social RT @DrBhana: Dr. Spiegal: On going big data study for early prediction of major CVD events using remote monitoring. #ACR18 @RheumNow https:…
22 Oct 2018 Social RT @KDAO2011: Great Pearl by Dr J Kremer: if a patient complains about hair loss with MTX, add leucovorin (but don’t administer same day as…
17 Oct 2018 News Update on Immune Checkpoint Inhibitor Toxicity
11 Oct 2018 Social Ustekinumab is already approved for Crohn's colitis, now shows efficacy in 960 refractory ulcerative colitis patients given 2 doses of 130 mg sc https://t.co/5ILFRAwOcZ
11 Oct 2018 Social Rituximab shown to be superior to tacrolimus in treating children with nephrotic syndrome with better 12 mos relapse-free survival rate (90.0% vs 63.3%) and less mean cumulative steroid use (25.8 vs 86.3 mg/kg). https://t.co/P1YzDmTvPh
07 Oct 2018 Social 6 million women get pregnant in the US annually, yet ~90% take at least one medication while pregnant or lactating. Why is there so little research done in pregnant women? NICHHD has sent 15 recommendations to Alex Azar at HHS for change. https://t.co/NSlK2Iv3fv
03 Oct 2018 Social ASPECT trial in 1250 Belgians shows a 20 and 30% increased risk of developing IBD & acute anterior uveitis, respectively after 10 yrs of axial SpA; IBD and AAU risk (not psoriasis) related to Dz duration and inflammation, https://t.co/BnMFCAKSSB
02 Oct 2018 Social RT @ArthurRheum: @RheumNow Have a number of patients on a IL17i and Otezla with mixed results... although not unexpected as most of these p…
02 Oct 2018 Social RT @DrPetryna: TCZ doesn’t meet primary end point in ph3 trial for AOSD but helps⬇️ steroid dose: ACR50 at wk 4 61.5% vs 30.8% PBO but p=0.…
01 Oct 2018 Social Most drugs have a labeled shelf life of 1-5 years; but this only applies to unopened containers. Study of 3005 lots different meds shows 88% unopened meds retain potency for 66 mos. Estimated that unopened meds retain >90% potency for 5 yrs https://t.co/Tv6DTYzUdS
27 Sep 2018 Social Systematic review examined 10 studies, 1156 patients with undifferentiated (UA) or arthralgia & showed that DMARD/steroids did not reduce the risk of RA in arthralgia only pts, but use in UA significantly reduced the risk (OR 0.73; 95% CI 0.56 to 0.97) https://t.co/ZImmumitD2