Friday, 20 Apr 2018

Drug Safety

Datesort ascending Type Title Save
07 Mar 2018 Social Checkout #RWCS fellow video by Dr. Anna Postolova as she presents a case of MTX in the Treatment of Granulomatosis Mastitis https://t.co/pt4wAPXsGr
05 Mar 2018 Social @RichardPAConway Read the article. While only a pilot study it showed that TCZ worked by all clinical parameters but that MRA looked poorly sensitive, even before Rx began. FDG-PET looks more reliable as an imaging assessment tool. https://t.co/r2r2oCk0Kj
05 Mar 2018 Social Rituximab associated adverse events are more common in treating lymphoma/leukemi ( 25-36%) than with autoimmune dz (9-17%) and are more common with splenomegaly, anemia, hx of allergies, age. https://t.co/gUREPFvbUb
02 Mar 2018 News Steroid Use During Rheumatoid Pregnancies
28 Feb 2018 News Inflammatory Arthritis Variants with Checkpoint Inhibitors
26 Feb 2018 Social Of 134 RTX treated pts (mean 79 mos), 23 (17%) developed Hypogammaglobulinemia after a mean 64 mos & assoc w/ 4x risk of severe infections. Gammaglobulin <8 g/L at baseline was a predictor of hypogamma (HR 7.34), but MTX was protective (HR 0.26) https://t.co/AMOtNAUeXR
26 Feb 2018 Social Nice update and review of Vaccination issues in Rheumatology - featuring insights from Drs. Len Calabrese, Steve Lindsey, Jeff Curtis, Kevin Winthrop & Betsy Kirchner ANP. https://t.co/xDTiO9xpHS
24 Feb 2018 Social Dr. Hyman Zimmerman is famous for drug-induced hepatocellular injury plus jaundice conferring a 10% mortality rate. "Hy's Law" is used by the FDA to judge serious hepatotoxicity and risk of death; Requires evidence of jaundice and ALT/AST >3x ULN https://t.co/fHa5ayHxmH
23 Feb 2018 Social Based on FDA review of a 10yr study, the FDA recommends that Biaxin (clarithromycin) not be used in patients with cardiac disesase as there may be a risk of increased risk of heart problems or death years later.
22 Feb 2018 News Equal Cardiovascular Risks in Hypertensive Patients Treated with Selective and Nonselective NSAIDS
21 Feb 2018 Social Dr. Hyman Zimmerman is famous for drug-induced hepatocellular injury plus jaundice conferring a 10% mortality rate. "Hy's Law" is used by the FDA to judge serious hepatotoxicity and risk of death; Requires evidence of jaundice and ALT/AST >3x ULN https://t.co/qu65fdGscf
21 Feb 2018 News ASCO/NCCN Guidelines for Checkpoint Inhibitor Immune-Related Adverse Events
16 Feb 2018 Social Pharmacovigilance using Twitter? A UK study compared glucocorticoid AE on Twitter vs UK MHRA regulatory system; in 3 yrs, Twitter Identified 20,210 Steroid AE, but only 3022 via MHRA. Twitter AE “common but not serious”, most being insomnia and weight gain https://t.co/T49kterWXS
15 Feb 2018 Social Lilly announces top line results of COAST-V trial showing the safety and efficacy of Taltz/ixekizumab (vs PBO vs adalimumab) in Ankylosing Spondylitis meeting primary and secondary endpoints (ASAS40) at 16 weeks. Resuts to likely be presented at EULAR https://t.co/0UBAjZTjDr
14 Feb 2018 Social FDA grants priority review for Genentechs Rituxan for use in pemphigus vulgaris https://t.co/e6uKQOf55f
11 Feb 2018 Social The RheumNow Wk in Review is up! Dr. Jack Cush discusses RWCS mtg, uricase exercise capillaroscopy & manpower. https://t.co/2WWmWNEL7G or listen to the podcast https://t.co/PgyBRjBq9w
10 Feb 2018 Social Dr Mark Genovese #RWCS - the rate of venous thromboembolic everts with baricitinib exposure appears to be 0.5 events per 100PY (basically the same rate seen in RA alone 0.5/100 PY) https://t.co/fRvLpHuDFP
09 Feb 2018 Social RT @uptoTate: Tofa 10mg BID may work for UC. Drs. Kavanaugh and Ruderman. #RWCS @RheumNow https://t.co/LE3tbTaKbF
04 Feb 2018 Social Risk factors for retinal toxicity associated with hydroxychloroquine include longer duration of HCQ use [adj OR 4.71], higher daily dose (3.34), presence of kidney disease (8.56) https://t.co/p8M4ezWLvG.
01 Feb 2018 Social Risk factors for retinal toxicity associated with hydroxychloroquine include longer duration of HCQ use [adj OR 4.71], higher daily dose (3.34), presence of kidney disease (8.56) https://t.co/A6sDsudCRq.