Wednesday, 21 Nov 2018

Drug Safety

Datesort ascending Type Title Save
31 Aug 2018 News New BSR Guidelines on Biologic Safe Use with Inflammatory Arthritis
28 Aug 2018 News The Safety of Paternal Exposure to DMARDs and Biologics
27 Aug 2018 News 2018-2019 ACIP Recommendations for Seasonal Influenza Vaccination
27 Aug 2018 Social FDA no longer labels drugs for pregnancy as A, B, C, D, X. New PLLR rule of 2015 - says pregnancy info includes more written data, from human studies, registries, less animal data. This review article looks a the history and what the new labeling entails https://t.co/0nWInWO1A4
27 Aug 2018 Social FDA info on insulin use during disaster/hurricaine applies well to biologic use - "...that insulin be stored...~36°F to 46°F" until use... but "may be left unrefrigerated at 59°F to 86°F for up to 28 days and continue to work" Avoid extremes in temp! https://t.co/gyxbhDdxVt
26 Aug 2018 Slide of the day Avoiding Teratogens in Pregnancy
25 Aug 2018 Social @CCalabreseDO @HealioRheum I STRONGLY disagree. The FDA, CDC and ETN, ADA & Infliximab worked this out long ago with Package insert language for LTBI saying "anti-TB therapy must be started BEFORE the TNF inhibitor" Specifically they meant give 300 mg INH, then give TNFi. "2-8wks" has no scientific basis
25 Aug 2018 Social @RajkiranDudam @psufka @PatelAarat @RheumRegistrar @RheumJC @shikhsingla @rajsengupta @MedReuma Easy. Lower MTX dose. Folate every day may help. In my experience vitamin A 8000 IU qd helps w/ nausea and oral ulcers much moreso than playing with folate use. https://t.co/Lryb3KAaWC
24 Aug 2018 Social RT @RheumNow: Which Anti-Rheumatic is shown/known to be a clear teratogen and thus pregnancy must be prevented/avoided when taking this dru…
23 Aug 2018 Social Which Anti-Rheumatic is shown/known to be a clear teratogen and thus pregnancy must be prevented/avoided when taking this drug?
22 Aug 2018 Social Systematic review show that adherence and persistence on etanercept and adalimumab are quite low, often 50% or less, somewhat better w/ infliximab. How to improve? Supervised injectables or infusions, pt education, drug levels? https://t.co/7tP8zmDr4R
20 Aug 2018 News Health Secretary Azar Eyes Rebate Reform
06 Aug 2018 Social MAINRITSAN2 compared fixed dose (q 6 mos) RTX to "tailored" RTX (to CD19, ANCA titers) in 162 AAV (GPA, MPA) pts - BVAS/relapse rates similar betw fixed (17%) vs tailored (10%) (p=0.22) w/ less infusions in the latter (248 vs 381). https://t.co/swFosJvgGp
06 Aug 2018 Social Open label study from India - 60 pts w/ diffuse systemic sclerosis Rx with open label monthly IV CYC 500 mg/m2 or RTX 1000 mg × 2 doses. At 6 months, the FVC and Rodnan skin score improved in RTX, but not CYC, pts. CYC had more toxicity. UNCONTROLLED. https://t.co/9ZqaIw7uM5
26 Jul 2018 Social FDA grants orphan drug status to lenabasum for dermatomyositis https://t.co/moiw3jCqyi
25 Jul 2018 Social Limited data on pregnancy outcomes with tofacitinib exposure encouraging. In RA , 47 women, 44 men exposed, w/ 1 congenital defect. https://t.co/Nti7w4ZscU In UC studies 11 maternal and 14 paternal exposures w/ no congenital malformations https://t.co/qOnzopZkB3
18 Jul 2018 Social CDC warns there is a shortage of the Shingles vaccine SHINGRIX. GSK has stated there are "order limits and shipping delays will continue throughout 2018.” https://t.co/tJb3qaDgtS
17 Jul 2018 Social Great Suggestions from Janet Pope - reduce MTX Rx errors by only prescribing it on their (Pts) preferred day of the week! https://t.co/gvXULBOm23
15 Jul 2018 Social Great Suggestions from Janet Pope - reduce MTX Rx errors by only prescribing it on their (Pts) preferred day of the week! https://t.co/gvXULBOm23
13 Jul 2018 Social Australian Safety update 28 cases of MTX mis-dosing - most taking weekly MTX dose as DAILY dose! AE: pancytopenia, thrombocytopenia, neutropenia, stomatitis, mucosal ulcers, GI effects. @Risk: nonEnglish, confusion w/ Folate,etc https://t.co/axTZWVyU9E