Friday, 18 Jan 2019

Drug Safety

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02 Oct 2018 Social RT @ArthurRheum: @RheumNow Have a number of patients on a IL17i and Otezla with mixed results... although not unexpected as most of these p…
02 Oct 2018 Social RT @DrPetryna: TCZ doesn’t meet primary end point in ph3 trial for AOSD but helps⬇️ steroid dose: ACR50 at wk 4 61.5% vs 30.8% PBO but p=0.…
01 Oct 2018 Social Most drugs have a labeled shelf life of 1-5 years; but this only applies to unopened containers. Study of 3005 lots different meds shows 88% unopened meds retain potency for 66 mos. Estimated that unopened meds retain >90% potency for 5 yrs https://t.co/Tv6DTYzUdS
27 Sep 2018 Social Systematic review examined 10 studies, 1156 patients with undifferentiated (UA) or arthralgia & showed that DMARD/steroids did not reduce the risk of RA in arthralgia only pts, but use in UA significantly reduced the risk (OR 0.73; 95% CI 0.56 to 0.97) https://t.co/ZImmumitD2
24 Sep 2018 Social Annals Int Med - analysis of adults prescribed opioids between 2006-2015 shows 31943 Rx visits for opioids - 5% for cancer pain, 66% for noncancer pain & 28.5% an Opioid was Rx without a pain Dx. https://t.co/6vKQbwEdkR
24 Sep 2018 Social Useful listing of Pregnancy Registries for drug info during pregnancy with arthritis, lupus and many other disorders including Mother to Baby, Pregnancy in FM, MS, OP, Breast cancer etc. https://t.co/sPETyaH9jX
18 Sep 2018 Social Open study of adalimumab and infliximab in recalcitrant (RV) retinal vasculitis (unresponsive to other therapies) - 48 pts Rx (1/2 ADA, 1/2 INFL) - RV remission within 54% @3 mos and 86% @ 12 mos. with no added benefit to other cotherapies. https://t.co/EvbFj6vXly
17 Sep 2018 Social NSAID-exacerbated respiratory disease occurs in 1/10 pts with asthma and rhinosinusitis- There are new expert guidelines on recognition, management, high morbidity and mortality risks. https://t.co/kY1RYSizqz
17 Sep 2018 Social Metanalysis of NSAID effects on CV risk (CVR) shows an overall, significant increased CVR (RR 1.24), especially for vascular events. Moreso for coxibs (RR 1.22) vs nonselective NSAIDs (1.18). CVR highest w/ rofecoxib (RR 1.39), then diclofenac & etoricoxib https://t.co/8LEDxYFTK4
14 Sep 2018 Social Correction 42%; Systemic onset JIA patients may have higher Injection Site Reaction rates when taking sc tocilizumab (42% sJIA) compared to polyarticular JIA (15-29%). RA ( 7-10%) or GCA https://t.co/ooDo1LjGlA
08 Sep 2018 Social RheumNow Week in Review is up! This week the sunshine folder & ugly tie rack! Watch the video here https://t.co/Lb0mFGPTHc or try the podcast on iTunes in your car or on Android Auto in your car on Stitcher or https://t.co/Lb0mFGPTHc
31 Aug 2018 News New BSR Guidelines on Biologic Safe Use with Inflammatory Arthritis
28 Aug 2018 News The Safety of Paternal Exposure to DMARDs and Biologics
27 Aug 2018 News 2018-2019 ACIP Recommendations for Seasonal Influenza Vaccination
27 Aug 2018 Social FDA no longer labels drugs for pregnancy as A, B, C, D, X. New PLLR rule of 2015 - says pregnancy info includes more written data, from human studies, registries, less animal data. This review article looks a the history and what the new labeling entails https://t.co/0nWInWO1A4
27 Aug 2018 Social FDA info on insulin use during disaster/hurricaine applies well to biologic use - "...that insulin be stored...~36°F to 46°F" until use... but "may be left unrefrigerated at 59°F to 86°F for up to 28 days and continue to work" Avoid extremes in temp! https://t.co/gyxbhDdxVt
26 Aug 2018 Slide of the day Avoiding Teratogens in Pregnancy
25 Aug 2018 Social @CCalabreseDO @HealioRheum I STRONGLY disagree. The FDA, CDC and ETN, ADA & Infliximab worked this out long ago with Package insert language for LTBI saying "anti-TB therapy must be started BEFORE the TNF inhibitor" Specifically they meant give 300 mg INH, then give TNFi. "2-8wks" has no scientific basis
25 Aug 2018 Social @RajkiranDudam @psufka @PatelAarat @RheumRegistrar @RheumJC @shikhsingla @rajsengupta @MedReuma Easy. Lower MTX dose. Folate every day may help. In my experience vitamin A 8000 IU qd helps w/ nausea and oral ulcers much moreso than playing with folate use. https://t.co/Lryb3KAaWC
24 Aug 2018 Social RT @RheumNow: Which Anti-Rheumatic is shown/known to be a clear teratogen and thus pregnancy must be prevented/avoided when taking this dru…