Wednesday, 21 Nov 2018

Drug Safety

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11 Jul 2018 Social Testosterone use in USA tripled from 2001 - 2011, mostly men without clear indication. In late 2013 2 studies reported increased MI & CVA risk associated with testosterone use and since decreased 50%.
09 Jul 2018 Social RT @MattieRheumMD: Once again PBM OBFUSCATION at its best!
09 Jul 2018 News Hydroxychloroquine Being Over-Dosed with New Guidelines?
09 Jul 2018 Social Pilot study of 23 pre-surgical Dupuytren's patients shows lesional injections of adalimumab reduced myofibroblast fibrotic markers in surgically removed tissues. Grounds for a study - Yes, but not for clinical current use
04 Jul 2018 Social "Prednisone is the best drug we have, and prednisone is the worst drug we have"- Peter A. Merkel, MD
03 Jul 2018 Social Year in Review. Dan Solomon reviews and shows no cancer risk with Biologics. #ACR17
03 Jul 2018 Social DMARD Tip: Leflunomide has a 1/2 life of nearly 20days. Once pt improved w/ 20mg/d (~6-12 wks) I switch dosing to once weekly, often less total mg (eg, LEF 4-6 tab q friday (80-120mg/wk). Monitoring and risks are same.
03 Jul 2018 Social Risk factors for retinal toxicity associated with hydroxychloroquine include longer duration of HCQ use [adj OR 4.71], higher daily dose (3.34), presence of kidney disease (8.56)
03 Jul 2018 Social Metanalysis of checkpoint inhibitor (nivolumab, pembrolizumab or atezolizumab)shows high rates of hypothyroidism (OR 7.6), pneumonitis (5.4), colitis (2.9), hypophysitis (3.4), rash (2.4), fatigue (32%), diarrhea (19%) &> 20% w/ arthraligia or back pain.
30 Jun 2018 Social The RheumNow Week in Review is up! Life Savers for Rheumatologists - on vaccinations, Bactrim prophylaxis & the downside of Febuxostat. Check out the podcast on iTunes, Stitcher,
27 Jun 2018 Social TMP/SMX prophylaxis following rituximab in ANCA+ associated vasculitis reduces infections by 70% (HR 0.30) - 192 AAV pts with 92 infx in 49 pts (only 1 due to PJP).
22 Jun 2018 Social RT @ACRheum: The ACR believes that safe and effective treatments should be accessible to all patients at the lowest possible cost. https://…
22 Jun 2018 Social RT @DrDavidKarp: Dr. Bonnie Bermas enlightens IM Grand Rounds no immune related adverse effects of checkpoint inhibitors. Great info!! ⁦@U…
21 Jun 2018 News NSAID Use Around Conception Increases Miscarriage Risk
20 Jun 2018 Social Cool video from Dr. Calabrese at #EULAR2018 on the use of avacopan (CCX168), an oral selective C5a receptor inhibitor, in treating ANCA associated vasculitis
19 Jun 2018 Social Checkout this audio file PODCAST from Day 1 & 2 at EULAR 2018 - listen here on on iTunes, Stitcher, etc.
18 Jun 2018 Social Checkout the EULAR Day 4 podcast on RheumNow, iTunes, etc.
17 Jun 2018 News Could Measuring Drug Levels with TNF Treatment Hurt Your Patients?
17 Jun 2018 Social RT @RonanTKavanagh: Nice summary of Checkpoint inhibitor immunologic side effects of relevance to rheumatologists from @zandbelt . https://…
16 Jun 2018 Social RT @LCalabreseDO: Beautiful study by Kostine suggesting IrAEs indicate + ant- tumor effect at #eular2018 Cancer Therapies Inducing Immune-R…