Tuesday, 21 May 2019

Drug Safety

Datesort ascending Type Title Save
11 Jan 2019 Social FDA AAC + DSRM advisory committee votes 19 yes, 2 no and 1 abstain on continued use of Uloric/febuxostat after reviewing CV risk in the CARES study. Await FDA decision, but Look for label changes.
08 Jan 2019 Social QD Video from RheumNow - Dicusssion of statins and myalgias/arthralgias. https://t.co/zKFZEF6MiL
07 Jan 2019 Social RheumNow Weekly Podcast is up - watch here: https://t.co/vAtEYSPIhG or listen on iTunes or here https://t.co/D3n7so7mN9
04 Jan 2019 Social FDA warns fluoroquinolone use may increase risk ofruptures or tears in the aorta. Thus Fluoroquinolones should not be used w/ aortic aneurysms, peripheral vascular Dz, HTN, Marfans/Ehlers-Danlos, or the elderly, unless there are no other options available https://t.co/aTEE0keIS8
01 Jan 2019 News Best of 2018: The Safety of Paternal Exposure to DMARDs and Biologics
31 Dec 2018 Social RT @NYTHealth: From @NYTOpinion: CBD is being touted as the latest miracle cure. Enthusiasts rave about its supposed anti-anxiety, anti-inf…
30 Dec 2018 Social "Prednisone is the best drug we have, and prednisone is the worst drug we have"- Peter A. Merkel, MD
28 Dec 2018 News Best of 2018: Hydroxychloroquine Being Over-Dosed with New Guidelines?
19 Dec 2018 Social Case reports of non-infectious pneumonia with Ustekinumab reported from FDA Adverse Event Reporting System (medwatch) - 12 cases, 7 interstitial pneumonia, 3 eosinophilic pneumonia, 1 each organizing pneumonia & hypersensitivity pneumonitis https://t.co/r9zGR0nTmc
17 Dec 2018 Social Check out Vinay Prasads @VPplenarysesh Plenary Session Podcast that discusses studies on Fish oils and MTX in cardiology - the CIRT NEJM study appears at 35:23 - interesting to hear non-Rheum views on this approach https://t.co/MQCWLYgEnD
15 Dec 2018 Social With irAEs arthralgias snd arthritis are common, but also can present as tendinitis tenosynovitis, dactylitis, PMR and most are seronegative https://t.co/WRvczdEsh9
13 Dec 2018 News CDC Top 15 Most Common Opioid Overdose Drugs
08 Dec 2018 Social RT @AngusWorthing: Bipartisan senators introduce new drug pricing bill https://t.co/mDWxPEtHhz
30 Nov 2018 Social The RheumNow Podcast is Up! To Needle or Not to Needle; Watch https://t.co/pjYZh5LXzi or listent to the weekly news and review https://t.co/AmXgjki2dL
30 Nov 2018 Social 296 women with HTN during pregnancy (half/147 NSAID-exposed) - NSAID use was not associated with a significant change in BP (vs no NSAID) and there was no added need to start or increase BP meds in those on NSAIDS. https://t.co/csDljBJI3r
26 Nov 2018 Social TB Testing - Do PPD or IGRA before TNFi or biologic - If negative, start therapy - If Positive, Eval for active TB (Sxs, CXR, C/S); if neg --> LTBI Rx BEFORE biologic - If "Indeterminate", repeat or change test. If same or neg--> start biologic - Do not do annual TST or IGRA
26 Nov 2018 News Trazodone High Risk of Falls and Fractures
26 Nov 2018 Social Could routine use of hydroxychloroquine reduce the rate of serious infections in immunosuppressed patients? A modest to moderate risk reduction noted in two large SLE cohort studies. https://t.co/pssLrteRRq
22 Nov 2018 Social Sudden discontinuation of duloxetine may have Adverse Events in up to 44% - dizziness, nauseam headache, paresthesia, vomiting, irritability, nightmares. Instead, its rec to gradually reduce dose over 2 weeks before D/C of duloxetine.https://t.co/aSGU0CVldB
19 Nov 2018 Social Drug interactions with Xeljanz (tofacitinib) - CP3A4 (ketoconazole) & CYP2C19 Inhibitors (fluconazole) may increase TOFA exposure; CYP3A4 Inducers (rifampin) may reduce TOFA; do not combine with other immunosuppressants (AZA, CsA, tacrolimus) https://t.co/yrs7RBmn2P