Wednesday, 21 Nov 2018

Drug Safety

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16 Jun 2018 News Methotrexate Update
15 Jun 2018 Social RT @DrPetryna: #EULAR18 @RheumNow ABST op0241 tocilizumab may reduce the incidence of vascular complications in TAkayasu Arteritis. Failur…
15 Jun 2018 Social RT @pkiely500: #EULAR2018 Relative risk of post surgical infections in bDMARD users finds no difference between MOA but picks up co-prescri…
15 Jun 2018 ACR Video Dr. Olga Petryna at EULAR2018 Discusses Pregnancy Outcomes with Secukinumab
14 Jun 2018 Social RT @DrPetryna: #EULAR18 @RheumNow ABST thu0294 5year aremilast update: improved PASI-50 65.8% (98/149) & PASI-75 43.6% (65/149). 62.4% of…
14 Jun 2018 Social RT @RonanTKavanagh: Allanor (EUSTAR) oral Retrospective multi centre study of Rituximab for SSc. 248 patients. Mean follow up 2.4 yrs. Imp…
14 Jun 2018 Social RT @Janetbirdope: When you stop adalimumab you are still on it for MONTHS THU0211 poster showed novel TNFI assay showing still bound TNFI…
13 Jun 2018 News Cancer Therapies Inducing Immune-Related Adverse Events (irAEs)
01 Jun 2018 Social NSAIDs may reduce risk of certain cancers, esp colorectal CA. But NSAIDs combined with phosphatidylcholine is superior to NSAIDs alone in animal models at preventing colon cancer https://t.co/Glgi21Ealg
01 Jun 2018 Social In RCTs, among 1157 ulcerative colitis pts receiving tofacitinib, 65 (5.6%) developed herpes zoster, 11 multidermatomal & 1 HZ encephalitis. HZ=4.07 with higher risk in elderly, Asians, prior TNFi failure & tofa 10 mg bid. https://t.co/LsPGIrzDvu
31 May 2018 Social CMAJ reports on a Canadian population study of 290,939 girls 12–17 yrs who received quadravalent HPV vaccine with no increased risk of subsequent autoimmune disease (eg, Graves, Bells, JIA, SLE, AIHA, etc) https://t.co/jtJBDlE6jv
27 May 2018 Social Dr Ridker announced the NIH stopped enrolling the CIRT trial; MTX vs PBO in high risk (non-RA) pts looking at CV outcomes. DSMB rec. stopping after 4,786/7000 enrolled, not for safety, but because of enough efficacy data accrued. Look for results in 11/18 https://t.co/n4PGybItkS
24 May 2018 Social Paul Ridker, MD announced the NIH stopped enrolling the CIRT trial; MTX vs PBO in high risk (non-RA) pts looking at CV outcomes. DSMB rec. stopping after 4,786/7000 enrolled, not for safety, but because of enough efficacy data. Look for results in 11/18 https://t.co/n4PGybItkS
14 May 2018 Social RheumNow Wk in Review is up; Nonadherence and Atronomic Costs. Listen to the podcast on iTunes or here https://t.co/fvuI23Oez6 or watch the videocast https://t.co/Mks5i6XVHm
09 May 2018 Social In an animal model of induced large vessel vasculitis, in vivo Rx w/ tofacitinib reduced JAK2 & JAK 2 cytokine signaling and suppressed tissue-resident memory T cells and vasculitic pathology. https://t.co/7JIMbryFxo
28 Apr 2018 Social RheumNow week in Review is up - FDA Showdown! Listen to the podcast on iTunes or here https://t.co/Kp5tcuaR2B or watch the video that makes children cry https://t.co/YjU5DgK0OH
25 Apr 2018 Social Among 2619 RA patients, use of hydroxychloroquine (n 1212) was associated with a lower risk of CKD (10.3 vs 13.8 per 1000PY); thus HCQ assoc w/ a lower risk of incident CKD (HZ 0.64; 95% confidence interval, 0.45 to 0.90; P=0.01) & was dose dependent https://t.co/MaTsZEDBKG
23 Apr 2018 Social French open label study 46 Takayasu pts shows tocilizumab IV improves disease activity and reduces steroid use and relapse rates. https://t.co/GXoxAtWvzw
19 Apr 2018 News Tobacco Associated Deaths in the USA
18 Apr 2018 Social Do the RheumNow LIVE VOTE Survey: is DVT/PE Risk from Disease or Drugs? If youre a RHEUMATOLOGIST - please vote in our quick 4Q survey today https://t.co/rmilEeZthL