Friday, 15 Nov 2019

Drug Safety

Datesort ascending Type Title Save
23 Apr 2019 Social Do you use PJP prophylaxis w/ Bactrim in RA pts? 2640 RA pts found only 19 cases of pneumocystis pneumonia. Risk factors were high dose MTX (OR 4.5), >65 yrs (OR 3.7), ≥2 ISPs (3.7), prednisolone ≥5 (OR 12.4) - a combo of these has a 2.3-5.8% riskof PJP.
22 Apr 2019 Slide of the day Vaccination Deficit in Rheumatology
12 Apr 2019 News Update on Vaccines in Autoimmune Patients
11 Apr 2019 Social 36 studies of 6662 depression patients shows the addition of antiinflammatory drugs (NSAIDs, steriods, statins, cytokine inhib, minocycline) improved antidepressant effects in Major Depression pts without increasing the risk of side‐effects.
11 Apr 2019 Social MMWR reports that for the 8th yr in a row the US TB rate dropped 1.3% to 2.8 per 100,000. In 2018 there were 9029 TB cases (69% in non–U.S.-born). TB risk in non-US born was >14 times that of U.S.-born persons.
10 Apr 2019 ACR Video RheumNow Live Preview with Dr. Len Calabrese
09 Apr 2019 Social 151 pts w/ myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) were treated with either rituximab or PBO showing no effect of RTX!! Really? someone, somewhere believes ME/CFS or FM is an immunologic dz? Do NOT use biologics, DMARDS in such pts.
08 Apr 2019 Social Long term safety study of 4481 tofacitinib pts w/ 9.5yrs exposure (16,291PYs). 52% discontinued Rx (4% insufficient response; 24% adverse events). AE incidence rates were 3.4/100PY for H zoster, 2.4/100Py SIE, 0.8 cancer, 0.4 MACE, 0.3 Mortality.
04 Apr 2019 Social RT @MattieRheumMD: NSAIDS can reduce fertility in women - from Dr Sammaritano. #RNL2019
03 Apr 2019 Social RT @RheumNow: #RNL2019 Dr Carol Langford discusses when to use RTX vs CTX in GPA
01 Apr 2019 News RheumNowLive On Demand: Infection Prevention and Management with Newer Agents - Jack Cush, MD
28 Mar 2019 Social Claims data analysis of 11,248 matched patients starting abatacept or TNFi showed the risk of hospitalized infection was 37 ABA vs 47 TNFi (HR 0.78; 95% CI 0.64-0.95). Thus ABA was associated with a 22% less risk any hospitalized infection.
27 Mar 2019 Social QD Clinic - Medication Reminders | RheumNow -Measures taken to remind or ensure medication compliance
27 Mar 2019 News Acute Problems Associated With Cannabis Use
25 Mar 2019 Social In newly Dx GPA it’s ok to treat with steroids PLUS MTX or MMF or RTX. #RNL2019 Dr Carol Langford
25 Mar 2019 Social #RNL2019 Dr Carol Langford discusses when to use RTX vs CTX in GPA
25 Mar 2019 Social After either RTX or CTX induction, 102 pts w/ ANCA-associated vasculitis were give maintenance w/ azathioprine plus belimumab or placebo. Belimumab did not reduce the flare rate (HR=1.07;) or relapse (HR=0.88) (NS) in these patients
18 Mar 2019 Social QD Clinic - When To Stop MTX- Should/Can a Patient ever stop MTX? | RheumNow
15 Mar 2019 Social The Weekly RheumNow Podcast is up! or listen to it on iTunes or SoundCloud
13 Mar 2019 Social GSK has issued a new safety warning on Benlysta with a low frequency risk of serious depression & suicidal ideation; new data added to PI based on new 4003 SLE pt trial with Suicidal ideation seen in 0.7% on BEL and 0.2% on PBO; depression (0.3% vs <0.1%)