Friday, 18 Jan 2019

Drug Safety

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01 Jun 2018 Social In RCTs, among 1157 ulcerative colitis pts receiving tofacitinib, 65 (5.6%) developed herpes zoster, 11 multidermatomal & 1 HZ encephalitis. HZ=4.07 with higher risk in elderly, Asians, prior TNFi failure & tofa 10 mg bid. https://t.co/LsPGIrzDvu
31 May 2018 Social CMAJ reports on a Canadian population study of 290,939 girls 12–17 yrs who received quadravalent HPV vaccine with no increased risk of subsequent autoimmune disease (eg, Graves, Bells, JIA, SLE, AIHA, etc) https://t.co/jtJBDlE6jv
27 May 2018 Social Dr Ridker announced the NIH stopped enrolling the CIRT trial; MTX vs PBO in high risk (non-RA) pts looking at CV outcomes. DSMB rec. stopping after 4,786/7000 enrolled, not for safety, but because of enough efficacy data accrued. Look for results in 11/18 https://t.co/n4PGybItkS
24 May 2018 Social Paul Ridker, MD announced the NIH stopped enrolling the CIRT trial; MTX vs PBO in high risk (non-RA) pts looking at CV outcomes. DSMB rec. stopping after 4,786/7000 enrolled, not for safety, but because of enough efficacy data. Look for results in 11/18 https://t.co/n4PGybItkS
14 May 2018 Social RheumNow Wk in Review is up; Nonadherence and Atronomic Costs. Listen to the podcast on iTunes or here https://t.co/fvuI23Oez6 or watch the videocast https://t.co/Mks5i6XVHm
09 May 2018 Social In an animal model of induced large vessel vasculitis, in vivo Rx w/ tofacitinib reduced JAK2 & JAK 2 cytokine signaling and suppressed tissue-resident memory T cells and vasculitic pathology. https://t.co/7JIMbryFxo
28 Apr 2018 Social RheumNow week in Review is up - FDA Showdown! Listen to the podcast on iTunes or here https://t.co/Kp5tcuaR2B or watch the video that makes children cry https://t.co/YjU5DgK0OH
25 Apr 2018 Social Among 2619 RA patients, use of hydroxychloroquine (n 1212) was associated with a lower risk of CKD (10.3 vs 13.8 per 1000PY); thus HCQ assoc w/ a lower risk of incident CKD (HZ 0.64; 95% confidence interval, 0.45 to 0.90; P=0.01) & was dose dependent https://t.co/MaTsZEDBKG
23 Apr 2018 Social French open label study 46 Takayasu pts shows tocilizumab IV improves disease activity and reduces steroid use and relapse rates. https://t.co/GXoxAtWvzw
19 Apr 2018 News Tobacco Associated Deaths in the USA
18 Apr 2018 Social Do the RheumNow LIVE VOTE Survey: is DVT/PE Risk from Disease or Drugs? If youre a RHEUMATOLOGIST - please vote in our quick 4Q survey today https://t.co/rmilEeZthL
17 Apr 2018 Social RheumNow is doing a Survey on DVT/PE Risk from Disease or Drugs; If youre a RHEUMATOLOGIST - please vote in our quick 4Q survey today https://t.co/rmilEeZthL
16 Apr 2018 Social RheumNow LIVE VOTE for RHEUMATOLOGISTS - What causes VTE - drugs or disease. RHEUMS Vote here: https://t.co/rmilEeZthL
16 Apr 2018 News EMA to Review Methotrexate Overdose and Dosing Errors
16 Apr 2018 News MMWR: Cannabis Use in the Colorado Workers
15 Apr 2018 Social RT @SGottliebFDA: #FDA is taking new steps to encourage drug companies to include pregnant women in clinical trials, issuing a draft guidan…
13 Apr 2018 Social RheumNow week in review is up! Do you Dig Shingrix? Listen to podcast on iTunes, Apple Car play, Stitcher https://t.co/CBksZ6eroy or watch it on the website https://t.co/retUQs5KLp
12 Apr 2018 Social In early arthritis clinics in Leeds and UK ERAS study (454 &895 pts), DMARD free remission seen in 15-9.4%; predictors included acute onset, short Sx duration, NO smoking, No Xray damage, Seronegativity, absent HLA shared epitope alleles https://t.co/3yulHyrS4O
11 Apr 2018 Social Generic drugs became law in 1967 & grew w/ Hatch-Waxman Act of 1984. They currently comprise 2/3 of all prescriptions. Heres a nice review of Generics by a pharmacist, for patients. https://t.co/K6xgkGreUE
07 Apr 2018 Social RT @philipcrobinson: Great data on tocilizumab and breast feeding https://t.co/1OQ5vhoSYL