Tuesday, 19 Nov 2019

Drug Safety

Datesort ascending Type Title Save
09 Apr 2019 Social 151 pts w/ myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) were treated with either rituximab or PBO showing no effect of RTX!! Really? someone, somewhere believes ME/CFS or FM is an immunologic dz? Do NOT use biologics, DMARDS in such pts. https://t.co/1xXG94QEnP
08 Apr 2019 Social Long term safety study of 4481 tofacitinib pts w/ 9.5yrs exposure (16,291PYs). 52% discontinued Rx (4% insufficient response; 24% adverse events). AE incidence rates were 3.4/100PY for H zoster, 2.4/100Py SIE, 0.8 cancer, 0.4 MACE, 0.3 Mortality. https://t.co/Qv5keuKXr3
04 Apr 2019 Social RT @MattieRheumMD: NSAIDS can reduce fertility in women - from Dr Sammaritano. #RNL2019
03 Apr 2019 Social RT @RheumNow: #RNL2019 Dr Carol Langford discusses when to use RTX vs CTX in GPA https://t.co/w0vWVrf7JX
01 Apr 2019 News RheumNowLive On Demand: Infection Prevention and Management with Newer Agents - Jack Cush, MD
28 Mar 2019 Social Claims data analysis of 11,248 matched patients starting abatacept or TNFi showed the risk of hospitalized infection was 37 ABA vs 47 TNFi (HR 0.78; 95% CI 0.64-0.95). Thus ABA was associated with a 22% less risk any hospitalized infection. https://t.co/Ij6b0IYcAZ
27 Mar 2019 Social QD Clinic - Medication Reminders | RheumNow -Measures taken to remind or ensure medication compliance https://t.co/7xnuGPeFxI
27 Mar 2019 News Acute Problems Associated With Cannabis Use
25 Mar 2019 Social In newly Dx GPA it’s ok to treat with steroids PLUS MTX or MMF or RTX. #RNL2019 Dr Carol Langford https://t.co/rihhR6x7u3
25 Mar 2019 Social #RNL2019 Dr Carol Langford discusses when to use RTX vs CTX in GPA https://t.co/w0vWVrf7JX
25 Mar 2019 Social After either RTX or CTX induction, 102 pts w/ ANCA-associated vasculitis were give maintenance w/ azathioprine plus belimumab or placebo. Belimumab did not reduce the flare rate (HR=1.07;) or relapse (HR=0.88) (NS) in these patients https://t.co/5EgdzRRXq8
18 Mar 2019 Social QD Clinic - When To Stop MTX- Should/Can a Patient ever stop MTX? | RheumNow https://t.co/z0Dhwdbr3Q
15 Mar 2019 Social The Weekly RheumNow Podcast is up! https://t.co/qA4wADpPN8 or listen to it on iTunes or SoundCloud https://t.co/mZ3y0yvwA3
13 Mar 2019 Social GSK has issued a new safety warning on Benlysta with a low frequency risk of serious depression & suicidal ideation; new data added to PI based on new 4003 SLE pt trial with Suicidal ideation seen in 0.7% on BEL and 0.2% on PBO; depression (0.3% vs <0.1%) https://t.co/cMp52MLKxs
12 Mar 2019 ACR Video QD Clinic - Shingles Happens
11 Mar 2019 Social PODCast of the last weeks QD Clinics can be found on iTUnes and here >> https://t.co/6SJHvbA2ho
08 Mar 2019 Social Systematic review of Paternal DMARD exposure prior to pregnancy shows no firm evidence of harm with TNFi, ABA, RTX, azathioprine, cyclosporine, HCQ, leflunomide, MTX or mycophenolate mofetil. Data from 84 papers, 611 male exposures, 5986 pregnancies https://t.co/yfIYoMqaRs
08 Mar 2019 Social Study of 6529 Afib pts on warfarin, 37.5% were also on aspirin. Adding aspirin to warfarin yielded significantly more bleeding (26 vs 20%), major bleeding (5.7 vs 3.3%), ER visits (13.3 vs 9.8%) but similar thrombosis rates (2.3 vs 2.7%) at 1 yr. https://t.co/m5XDBEN6jh
07 Mar 2019 Social Risk of pancreatitis with azathioprine in adults estimated to be 3-7%, but unknown in kids. 3374 pairs of pediatric IBD pts compared pts on AZA vs not. AZA use was associated with a 5.82 events/100PY risk of pancreatitis (AZA 49·1 vs NOT 8·4 events/100PY) https://t.co/arap2ShTPN
06 Mar 2019 Social QD Clinic - Five Leflunomide Pearls | from RheumNow https://t.co/A4dwd0eTQ9