Thursday, 21 Nov 2019

Drug Safety

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19 Nov 2017 Social RheumNow Week in Review is up! Watch on https://t.co/o6Mv4n9vQp or subscribe to the podcase on iTunes or here https://t.co/r4ndrsHSSl
25 Oct 2015 Social RT @LCalabreseDO: ACIP approves updates to 2016 adult immunization schedule - Rheumatologists need to know!! https://t.co/CDIykESO8C @Rheu…
09 Jan 2018 Social Gabapentinoid use steadily rose from 1.2% of adults in 2002 to 3.9% in 2015 https://t.co/seC0thDIX9
15 Jun 2018 Social RT @pkiely500: #EULAR2018 Relative risk of post surgical infections in bDMARD users finds no difference between MOA but picks up co-prescri…
25 Oct 2018 Social RT @psufka: Even low dose prednisone (5mg/day) associated with increased cumulative risk of infection #ACR18 @rheumnow https://t.co/UULnw8L…
08 Apr 2019 Social Long term safety study of 4481 tofacitinib pts w/ 9.5yrs exposure (16,291PYs). 52% discontinued Rx (4% insufficient response; 24% adverse events). AE incidence rates were 3.4/100PY for H zoster, 2.4/100Py SIE, 0.8 cancer, 0.4 MACE, 0.3 Mortality. https://t.co/Qv5keuKXr3
15 Oct 2019 Social Statin induced myopathy is occurs in less than 1%; rhabdomyolysis and necrotizing myositis are very rare. HMGCR Abs against (HMG-CoA) reductase are seen 2- 3 of every 100,000 patients treated with statins. https://t.co/44DGaHEGjo
19 Sep 2016 Social In Spain, after a neg PPD, in 1st 1-2 yrs on TNFI theres a 4.3% seroconvert w/ repeat PPD, thought to be LTBI https://t.co/f7anCsSvma
17 Feb 2017 Social RT @DrRachelTate: TNFi induced PsO. George Martin, MD #rwcs2017 @RWCSmtg @RheumNow https://t.co/eda8N9bQZ3
14 Jul 2015 Social Drug Safety DONTs:1) use anothers pills; 2) change dosingt; 3) crush tablets; 4) ignore expire date; 5) store in heat http://t.co/RXiBA4jQgB
13 May 2016 Social FDA warns that serious side effx of fluoroquinolones obviates use in sinusitis, bronchitis, UTI (safer Rx options) https://t.co/lWLyBfbd5V
24 May 2017 Social Claims data on 2495 JIA pts shows significantly more serious bacterial infx w/ TNFi use (HR 2.72) compared to DMARDs https://t.co/CKu9oIOzlj
22 Oct 2017 Social RT @DrPetryna: CRIB:1/14 newborns had minim CZP levels, rest undetect,umb cord 3/15 +CZP -safe to cont CZP in pregnancy https://t.co/lcqHTK…
10 Feb 2018 Social Dr Mark Genovese #RWCS - the rate of venous thromboembolic everts with baricitinib exposure appears to be 0.5 events per 100PY (basically the same rate seen in RA alone 0.5/100 PY) https://t.co/fRvLpHuDFP
03 Jul 2018 Social DMARD Tip: Leflunomide has a 1/2 life of nearly 20days. Once pt improved w/ 20mg/d (~6-12 wks) I switch dosing to once weekly, often less total mg (eg, LEF 4-6 tab q friday (80-120mg/wk). Monitoring and risks are same. https://t.co/IDd1UaCbp7
26 Nov 2018 Social TB Testing - Do PPD or IGRA before TNFi or biologic - If negative, start therapy - If Positive, Eval for active TB (Sxs, CXR, C/S); if neg --> LTBI Rx BEFORE biologic - If "Indeterminate", repeat or change test. If same or neg--> start biologic - Do not do annual TST or IGRA
07 May 2019 Social RT @philipcrobinson: A bit of welcome data on this -> Abatacept concentrations in maternal serum and breast milk during breastfeeding and a…
11 Nov 2019 Social RT @philipcrobinson: Toxicity of JAK inhibitors #ACR19 @RheumNow https://t.co/rqy1IfSEyP
12 Oct 2016 Social Medicare study shows no increased risk of breast cancer in RA or IBD women taking MTX, 6MP or TNF inhibitors! https://t.co/lHyUbyjNCQ
20 Mar 2017 Social IBD may be a rare complication of systemic JIA treated with IL-1 inhibitors - 3/81 cases ID by retrospective review https://t.co/EAa0xNrD69