Thursday, 21 Nov 2019

Drug Safety

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19 Nov 2017 Social RheumNow Week in Review is up! Watch on or subscribe to the podcase on iTunes or here
25 Oct 2015 Social RT @LCalabreseDO: ACIP approves updates to 2016 adult immunization schedule - Rheumatologists need to know!! @Rheu…
09 Jan 2018 Social Gabapentinoid use steadily rose from 1.2% of adults in 2002 to 3.9% in 2015
15 Jun 2018 Social RT @pkiely500: #EULAR2018 Relative risk of post surgical infections in bDMARD users finds no difference between MOA but picks up co-prescri…
25 Oct 2018 Social RT @psufka: Even low dose prednisone (5mg/day) associated with increased cumulative risk of infection #ACR18 @rheumnow…
08 Apr 2019 Social Long term safety study of 4481 tofacitinib pts w/ 9.5yrs exposure (16,291PYs). 52% discontinued Rx (4% insufficient response; 24% adverse events). AE incidence rates were 3.4/100PY for H zoster, 2.4/100Py SIE, 0.8 cancer, 0.4 MACE, 0.3 Mortality.
15 Oct 2019 Social Statin induced myopathy is occurs in less than 1%; rhabdomyolysis and necrotizing myositis are very rare. HMGCR Abs against (HMG-CoA) reductase are seen 2- 3 of every 100,000 patients treated with statins.
19 Sep 2016 Social In Spain, after a neg PPD, in 1st 1-2 yrs on TNFI theres a 4.3% seroconvert w/ repeat PPD, thought to be LTBI
17 Feb 2017 Social RT @DrRachelTate: TNFi induced PsO. George Martin, MD #rwcs2017 @RWCSmtg @RheumNow
14 Jul 2015 Social Drug Safety DONTs:1) use anothers pills; 2) change dosingt; 3) crush tablets; 4) ignore expire date; 5) store in heat
13 May 2016 Social FDA warns that serious side effx of fluoroquinolones obviates use in sinusitis, bronchitis, UTI (safer Rx options)
24 May 2017 Social Claims data on 2495 JIA pts shows significantly more serious bacterial infx w/ TNFi use (HR 2.72) compared to DMARDs
22 Oct 2017 Social RT @DrPetryna: CRIB:1/14 newborns had minim CZP levels, rest undetect,umb cord 3/15 +CZP -safe to cont CZP in pregnancy…
10 Feb 2018 Social Dr Mark Genovese #RWCS - the rate of venous thromboembolic everts with baricitinib exposure appears to be 0.5 events per 100PY (basically the same rate seen in RA alone 0.5/100 PY)
03 Jul 2018 Social DMARD Tip: Leflunomide has a 1/2 life of nearly 20days. Once pt improved w/ 20mg/d (~6-12 wks) I switch dosing to once weekly, often less total mg (eg, LEF 4-6 tab q friday (80-120mg/wk). Monitoring and risks are same.
26 Nov 2018 Social TB Testing - Do PPD or IGRA before TNFi or biologic - If negative, start therapy - If Positive, Eval for active TB (Sxs, CXR, C/S); if neg --> LTBI Rx BEFORE biologic - If "Indeterminate", repeat or change test. If same or neg--> start biologic - Do not do annual TST or IGRA
07 May 2019 Social RT @philipcrobinson: A bit of welcome data on this -> Abatacept concentrations in maternal serum and breast milk during breastfeeding and a…
11 Nov 2019 Social RT @philipcrobinson: Toxicity of JAK inhibitors #ACR19 @RheumNow
12 Oct 2016 Social Medicare study shows no increased risk of breast cancer in RA or IBD women taking MTX, 6MP or TNF inhibitors!
20 Mar 2017 Social IBD may be a rare complication of systemic JIA treated with IL-1 inhibitors - 3/81 cases ID by retrospective review