Wednesday, 18 Sep 2019

Drug Safety

Date Typesort ascending Title Save
07 Mar 2018 Social Checkout #RWCS fellow video by Dr. Anna Postolova as she presents a case of MTX in the Treatment of Granulomatosis Mastitis
13 May 2016 Social FDA warns that serious side effx of fluoroquinolones obviates use in sinusitis, bronchitis, UTI (safer Rx options)
07 May 2019 Social RT @philipcrobinson: A bit of welcome data on this -> Abatacept concentrations in maternal serum and breast milk during breastfeeding and a…
29 Apr 2017 Social #SOTA2017 Dr Sherine Gabriel retrospective cohort study suggests acute MI risk maybe be lower with a be abatacept c…
19 Sep 2016 Social In Spain, after a neg PPD, in 1st 1-2 yrs on TNFI theres a 4.3% seroconvert w/ repeat PPD, thought to be LTBI
17 Feb 2017 Social RT @DrRachelTate: TNFi induced PsO. George Martin, MD #rwcs2017 @RWCSmtg @RheumNow
19 Apr 2015 Social w/ recent Listeria outbreaks, @ risk include infliximab, otherTNFi, MTX & Pred; rarely RTX or ABA, Mortality 11-27% ?
03 Jul 2018 Social DMARD Tip: Leflunomide has a 1/2 life of nearly 20days. Once pt improved w/ 20mg/d (~6-12 wks) I switch dosing to once weekly, often less total mg (eg, LEF 4-6 tab q friday (80-120mg/wk). Monitoring and risks are same.
26 Nov 2018 Social TB Testing - Do PPD or IGRA before TNFi or biologic - If negative, start therapy - If Positive, Eval for active TB (Sxs, CXR, C/S); if neg --> LTBI Rx BEFORE biologic - If "Indeterminate", repeat or change test. If same or neg--> start biologic - Do not do annual TST or IGRA
08 Oct 2017 Social RheumNOw Wk in Review is Up! Tof lymphoma risk, early Dx of RA, Preg & biologics, 2016 top 5 Rheumatology drugs.
19 Nov 2017 Social RheumNow Week in Review is up! Watch on or subscribe to the podcase on iTunes or here
15 Apr 2018 Social RT @SGottliebFDA: #FDA is taking new steps to encourage drug companies to include pregnant women in clinical trials, issuing a draft guidan…
24 May 2017 Social Claims data on 2495 JIA pts shows significantly more serious bacterial infx w/ TNFi use (HR 2.72) compared to DMARDs
12 Oct 2016 Social Medicare study shows no increased risk of breast cancer in RA or IBD women taking MTX, 6MP or TNF inhibitors!
20 Mar 2017 Social IBD may be a rare complication of systemic JIA treated with IL-1 inhibitors - 3/81 cases ID by retrospective review
05 May 2015 Social Review of Legionairres disease and deaths revealed higher risk in men, patients w/ leukemia or RA.
22 Aug 2018 Social Systematic review show that adherence and persistence on etanercept and adalimumab are quite low, often 50% or less, somewhat better w/ infliximab. How to improve? Supervised injectables or infusions, pt education, drug levels?
13 Jan 2019 Social Rheumatology Year in Review : New Drugs, irAEs, Enbrel in court, Opioids, new JAKs, Hot PsA Trial, new Lupus drugs, Medical Marijuana, Expen$ive Rheum drugs, Senolytics.
30 Jan 2016 Social @RonanTKavanagh Very large 683 cohort only showed NS trend. Probs? 1) mixed RA w/ PsA/IBD; 2) unable to adjust for Dz activity,Age, comorb.
22 Oct 2017 Social RT @DrPetryna: CRIB:1/14 newborns had minim CZP levels, rest undetect,umb cord 3/15 +CZP -safe to cont CZP in pregnancy…