Friday, 15 Nov 2019

Drug Safety

Datesort ascending Type Title Save
30 Nov 2018 Social 296 women with HTN during pregnancy (half/147 NSAID-exposed) - NSAID use was not associated with a significant change in BP (vs no NSAID) and there was no added need to start or increase BP meds in those on NSAIDS.
26 Nov 2018 Social TB Testing - Do PPD or IGRA before TNFi or biologic - If negative, start therapy - If Positive, Eval for active TB (Sxs, CXR, C/S); if neg --> LTBI Rx BEFORE biologic - If "Indeterminate", repeat or change test. If same or neg--> start biologic - Do not do annual TST or IGRA
26 Nov 2018 News Trazodone High Risk of Falls and Fractures
26 Nov 2018 Social Could routine use of hydroxychloroquine reduce the rate of serious infections in immunosuppressed patients? A modest to moderate risk reduction noted in two large SLE cohort studies.
22 Nov 2018 Social Sudden discontinuation of duloxetine may have Adverse Events in up to 44% - dizziness, nauseam headache, paresthesia, vomiting, irritability, nightmares. Instead, its rec to gradually reduce dose over 2 weeks before D/C of duloxetine.
19 Nov 2018 Social Drug interactions with Xeljanz (tofacitinib) - CP3A4 (ketoconazole) & CYP2C19 Inhibitors (fluconazole) may increase TOFA exposure; CYP3A4 Inducers (rifampin) may reduce TOFA; do not combine with other immunosuppressants (AZA, CsA, tacrolimus)
18 Nov 2018 Social The RheumNow Podcast is up! THe Heartbreak of CIRT & MTX. view it or listen to the Podcast on iTunes or here
12 Nov 2018 Social NEJM publishes the CIRT trial - Methotrexate given to stable atherosclerosis patients for nearly 3 years was equal to placebo in the prevention of cardiovascular outcomes (MI, CVA, death, unstable angina). Story covered on RheumNow
11 Nov 2018 Social The RheumNow Podcast is up - 3 Wiseguy Rheumatologists. Watch it here or listen on iTunes or here
07 Nov 2018 News Musculoskeletal Events with Statin Use
06 Nov 2018 News Low Short-Term Risks of NSAIDs in High Risk Patients
05 Nov 2018 Social DEA report says 2017 was a record year for Opioid Overdose deaths - 72,000 or ~ 200 deaths per day; lead by Heroin, fentanyl, other opioids, methamphetamine and cocaine.
01 Nov 2018 News Update on Checkpoint Inhibitor Safety
29 Oct 2018 News Anti-phospholipid Antibodies and Myocardial Infarction.
29 Oct 2018 Social The ACR 2018 RheumNow Review is up! Watch it here or listen on iTunes or SoundCloud
26 Oct 2018 Social RT @ARD_BMJ: New ACR guidelines for treatment management during pregnancy in patients with rheumatic diseases #ACR18 > AM…
25 Oct 2018 Social RT @NicoleBitencou5: Compunded triamcinolone hexacetonide (the steroid formerly know as #Aritospan) showed significantly lower rates of joi…
25 Oct 2018 Social RT @psufka: Even low dose prednisone (5mg/day) associated with increased cumulative risk of infection #ACR18 @rheumnow…
25 Oct 2018 Social RT @synovialjoints: Case reports prompted prospective trial from Tsuji H showing evidence of combined high dose GC + TAC + CYC beneficial i…
24 Oct 2018 Social RT @ArthurRheum: Bimekizimab phase 2 presented at #ACR18 with extremely impressive results for joints and skin improvement (in fact the pri…