Friday, 18 Oct 2019

Drug Safety

Datesort ascending Type Title Save
06 Aug 2018 Social MAINRITSAN2 compared fixed dose (q 6 mos) RTX to "tailored" RTX (to CD19, ANCA titers) in 162 AAV (GPA, MPA) pts - BVAS/relapse rates similar betw fixed (17%) vs tailored (10%) (p=0.22) w/ less infusions in the latter (248 vs 381).
06 Aug 2018 Social Open label study from India - 60 pts w/ diffuse systemic sclerosis Rx with open label monthly IV CYC 500 mg/m2 or RTX 1000 mg × 2 doses. At 6 months, the FVC and Rodnan skin score improved in RTX, but not CYC, pts. CYC had more toxicity. UNCONTROLLED.
26 Jul 2018 Social FDA grants orphan drug status to lenabasum for dermatomyositis
25 Jul 2018 Social Limited data on pregnancy outcomes with tofacitinib exposure encouraging. In RA , 47 women, 44 men exposed, w/ 1 congenital defect. In UC studies 11 maternal and 14 paternal exposures w/ no congenital malformations
18 Jul 2018 Social CDC warns there is a shortage of the Shingles vaccine SHINGRIX. GSK has stated there are "order limits and shipping delays will continue throughout 2018.”
17 Jul 2018 Social Great Suggestions from Janet Pope - reduce MTX Rx errors by only prescribing it on their (Pts) preferred day of the week!
15 Jul 2018 Social Great Suggestions from Janet Pope - reduce MTX Rx errors by only prescribing it on their (Pts) preferred day of the week!
13 Jul 2018 Social Australian Safety update 28 cases of MTX mis-dosing - most taking weekly MTX dose as DAILY dose! AE: pancytopenia, thrombocytopenia, neutropenia, stomatitis, mucosal ulcers, GI effects. @Risk: nonEnglish, confusion w/ Folate,etc
11 Jul 2018 Social Testosterone use in USA tripled from 2001 - 2011, mostly men without clear indication. In late 2013 2 studies reported increased MI & CVA risk associated with testosterone use and since decreased 50%.
09 Jul 2018 Social RT @MattieRheumMD: Once again PBM OBFUSCATION at its best!
09 Jul 2018 News Hydroxychloroquine Being Over-Dosed with New Guidelines?
09 Jul 2018 Social Pilot study of 23 pre-surgical Dupuytren's patients shows lesional injections of adalimumab reduced myofibroblast fibrotic markers in surgically removed tissues. Grounds for a study - Yes, but not for clinical current use
04 Jul 2018 Social "Prednisone is the best drug we have, and prednisone is the worst drug we have"- Peter A. Merkel, MD
03 Jul 2018 Social Year in Review. Dan Solomon reviews and shows no cancer risk with Biologics. #ACR17
03 Jul 2018 Social DMARD Tip: Leflunomide has a 1/2 life of nearly 20days. Once pt improved w/ 20mg/d (~6-12 wks) I switch dosing to once weekly, often less total mg (eg, LEF 4-6 tab q friday (80-120mg/wk). Monitoring and risks are same.
03 Jul 2018 Social Risk factors for retinal toxicity associated with hydroxychloroquine include longer duration of HCQ use [adj OR 4.71], higher daily dose (3.34), presence of kidney disease (8.56)
03 Jul 2018 Social Metanalysis of checkpoint inhibitor (nivolumab, pembrolizumab or atezolizumab)shows high rates of hypothyroidism (OR 7.6), pneumonitis (5.4), colitis (2.9), hypophysitis (3.4), rash (2.4), fatigue (32%), diarrhea (19%) &> 20% w/ arthraligia or back pain.
30 Jun 2018 Social The RheumNow Week in Review is up! Life Savers for Rheumatologists - on vaccinations, Bactrim prophylaxis & the downside of Febuxostat. Check out the podcast on iTunes, Stitcher,
27 Jun 2018 Social TMP/SMX prophylaxis following rituximab in ANCA+ associated vasculitis reduces infections by 70% (HR 0.30) - 192 AAV pts with 92 infx in 49 pts (only 1 due to PJP).
22 Jun 2018 Social RT @ACRheum: The ACR believes that safe and effective treatments should be accessible to all patients at the lowest possible cost. https://…