Tuesday, 17 Sep 2019


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16 Sep 2019 Social Review of 24 guidance papers on gouts shows agreement over T2T fo ruric acid level and long-term controlindications for urate-lowering therapy 1st line drugs acute attack. Inconsistent were the initiation of ULT & Rx of asymptomatic hyperuricemia. https://t.co/j6v2Jp8L9t
11 Sep 2019 Social UK Clinical Practice Database compared 68,897 gout pts vs 554,964 without gout, showing gout doubles risk of (8.5/1000PY vs 4.1/1000PY w/o gout). Risk highest with ESRD. Gout did not increase CKD related deaths. https://t.co/oHpxa3ybVK
05 Sep 2019 News Modifiable Risk Factors for Hyperuricemia
20 Aug 2019 Social 87 #Gout patients treated with ULT and followed with serial Xrays and DECT scanning shows that lowering uric acid in a T2T strategy did not change xray over 2 years, but did show significantly less urate erosions by DECT. https://t.co/XRwkyyI4lr
14 Aug 2019 Social Cross sectional analysis of ~3000 and meta-analysis (14 studies) finds #gout has a higher risk of hypothyroidism, esp in female gout pts (OR=2.44;1.15-5.17); Metaanalysis ^risk hypothyroidism in gout (OR=1.51) and hyperuricemic pts (OR=1.34) https://t.co/1w3xfHqryJ
08 Aug 2019 Social Internet based study by Choi et al - looked at 517 gout patients and examined if gout flares were associated with vaccination. They found a twofold higher odds of gout flare (adjusted OR 1.99; 95% CI 1.01 to 3.89 in those who were vaccinated (any vaccine). https://t.co/8zLSt3YVZF
07 Aug 2019 Social Prospective study of 83 gout patients; 77 on urate lowering Rx, 6 discontinued Rx. The D/C group had no change in MSU deposits or SUA levels, In the ULT group MSU burden significantly decreased (MSU volume: p=0.007) and sUA dropped from 7.2 to 5,8 mg/dl. https://t.co/YfXjTKz1va
07 Aug 2019 Social PLoS reports that a study of 10,059 men from Israel were followed serially showing that higher variability in serum Uric Acid levels over 5 years was clearly predictive of 18-year Coronary heart disease and all-cause mortality. https://t.co/bDqI32aVXt
02 Aug 2019 Social 70 #gout pts studied & 44.3% developed post-surgical flares. Risk factors included Presurgical sUA ≥ 9 mg/dL (OR 3.77) & sUA changes before and after surgery (OR 1.62); but \allopurinol reduced risk (OR 0.15). Mean time to flare=3.7 days. Knee > MTP1 https://t.co/U6rl5c8Cf3
31 Jul 2019 Social Observational study of 124 gouty patients with high cholesterol & triglycerides treated with ULT (febuxostat, allopurinol, benzbromarone) showed that ULT significantly lowered SUA and lipid levels too. https://t.co/JSdh3TRTX3
31 Jul 2019 Social NHANES analysis shows that higher serum uric acid (SUA) levels had a greater risk of coronary heart disease and stroke mortality (mainly women >50 years); but there was no link between SUA and all-cause and cancer mortality. https://t.co/UGNSiKsjQl
26 Jul 2019 Social FDA has approved generic febuxostat 40 mg & 80 mg tabs, for gout - to be made by Read more at Business Medical Dialogues: Alembic Pharma gets USFDA nod for generic version of Uloric tablets https://t.co/QpnIoltFEP
21 Jul 2019 Social The RheumNow Podcast is up! Discussions on MDA-5 Abs & DM; gout & narcotics; IA capsaicin in OA; and ADA vs UPA. Watch here>> https://t.co/gZRJ2eHCqB or listen on iTunes or SoundCloud>> https://t.co/x6mCEqg6gU
19 Jul 2019 Social Mayo study comparing 429 Gout patients in 1990 and 2010 shows less 1st time Podagra 74% to 59% (p<0.001) and 24% higher flare rates in 2010. Predictors of future flares were hyperuricemia (HR 1.59) and CKD (HR 1.34) https://t.co/ZCgCzO7dUs
16 Jul 2019 Social ER study from 2015-17 shows that among 456 #gout patients, 28.3%) received opioid at discharge; 80% of these were new. Average dose was 38mg morphine equivalent for a median of 8 days - more likely w/ polyarticular gout, hx diabetes & hx prior opioids https://t.co/xf2jD1i4hg
08 Jul 2019 News Opioids Overused in Acute Gout
04 Jul 2019 Social RT @RheumNow: Comparison of high and low iris acid levels in a large cohort of gout patients shows high SUA associated with more comorbidit…
03 Jul 2019 Social RT @GoutGroup: #Hyperuricemia (HUC) /#gout found to be associated with CVD in a cohort of 37,315 PsA patients. Investigators at Icahn Mt S…
03 Jul 2019 News Allopurinol Fails to Curtail Hypertension
03 Jul 2019 Social RT @RheumNow: Dr. Peter Lipsky - 1 Million #Gout Patients & who cares for them. SAT0435 #EULAR2018 https://t.co/WfFR4tRf2p