Friday, 18 Oct 2019


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27 Oct 2017 Social Metanalysis of ULT adherence in Gout, 16 studies show adherence 46-48%, higher w/age, DM, HTN comorbidity
22 Sep 2016 Social Pegloticase failure linked to PEG Abs - may be improved/tolerated by concomitant Imuran - interesting case report
04 Jun 2019 Social UK Clinical Practice Database matched 62,234 pts with and without gout showing more venous thromboembolic events in gout (0.373 vs 0.27 per 100 Pt-yrs) (aHR 1.25, 95% CI 1.15–1.35) - not affected by ULT & not significant while in hospital (aHR 1.01)
25 Oct 2016 Social Rheumatoid nodules almost never ulcerate; but gout tophi DO! Risk factors age, tophus size & no protective sensation
18 Jun 2019 Social RT @GoutGroup: #EULAR2019 Come hear the latest on gout! Room N103 16:15-17:45 today. Risk:Exciting new genetics, occupational hazard, diet…
23 Oct 2018 Social Filming now: our gout panel with these terrific people. We'll post it up tonight on #gout #ACR18
18 Dec 2017 Social Check out Dr. Ken Saags #ACR17 video on the Triple study - how a tolerizing dose of pegloticase makes it safer and more tolerable!
31 Jul 2019 Social Observational study of 124 gouty patients with high cholesterol & triglycerides treated with ULT (febuxostat, allopurinol, benzbromarone) showed that ULT significantly lowered SUA and lipid levels too.
25 Jan 2019 Social Using the 1998-2014 U.S. National Inpatient Sample- gout was associated with 9-20% higher healthcare utilization and 6% higher hazard of transfusion after primary hip replacement surgery.
23 Feb 2018 Social Gout management by UK Rheums conform to guidelines, yet ~45% reach target SUA<6.0. Study of 4343 Gout pts; 82% M; 13% crystal-proven. 29% stopped diuretic, 76% on ULT; prophylaxis was co-prescribed for 94%.
01 Aug 2015 Social 81 arthritis pts (1/2 w/ gout) were studied w/ DECT scans. DECT had sensitivity of 90% and specificity of 83%.
13 Mar 2017 Social In 2002, there was 3.9 million outpatient visits for #Gout - only 1.3% were to rheumatologists.
17 Apr 2018 Social Using the 2012 ACR gout guidelines, an ACR working group developed new quality measures for gout: 1) evaluating indications for ULT; 2) monitoring serum urate; 3)treat-to-target outcome. But only 32%-58% of pts achieve these; thus room for improvement!
07 Oct 2015 Social The price of generics more than doubled in 1/7 generics. Colchicine price rose 2000% w/ FDA new safety policies.
24 Jul 2017 Social Discrepancy between ultrasound and DECT quantification of urate tophi in gout joints; lower sensitivity w/ DECT
31 Jul 2018 Social NLRP3 inflammasome-associated diseases (Gout, RA) could be regulated by inhibitors of CMPK2, produced after engagement of Toll receptors, CMPK2 needed for synthesis of mitochondrial DNA that drives NLRP3 activity and IL-1.
26 Aug 2016 Social Gout patients have a 17% increased risk of fractures ( limbs & spine). Interestingly allopurinol use lowers risk
16 Jun 2018 Social RT @Janetbirdope: A sore toe can kill you! Danish population study excluded past cancers and found pts with goit had mor cancer. Lymphoma c…
25 Nov 2015 Social Danish population study shows 7127 people on allopurinol have 11% less CV mortality and 32% all cause mortality
05 Nov 2017 Social RT @_connectedcare: DASH diet lowering urate in specific subgroups #ACR17 @rheumnow