Friday, 15 Nov 2019


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13 Nov 2019 ACR Video Panel Presentation: Gout
11 Nov 2019 ACR Video Treatment to Reduce Inflammation During Gout Flares: Dr. Olga Petryna
08 Nov 2019 News T2T Lowers Mortality in Gout
29 Oct 2019 News Novel Inhibition of MSU Crystal Inflammation
26 Oct 2019 Social Matched cohort study of 3763 AS & 19,214 controls, shows that gout and AS can coexist - gout found in 1.94% of AS and 0.56% of controls (OR 3.53, P < 0.001). AS was independently associated with gout (OR 1.41, P = 0.037).
24 Oct 2019 News Patients Prefer Nurse Led Care for their Gout
03 Oct 2019 Social Choi and colleagues have shown that allopurinol-associated severe cutaneous adverse reactions are higher with Heart (RR 1.44) and Renal (11 fold) disease. Initating low-dosage allopurinol may substantially mitigate this risk.
01 Oct 2019 News Anakinra Use in Hospitalized Gout Patients
20 Sep 2019 News Higher Rates of Venous Thromboembolism in Gout
16 Sep 2019 Social Review of 24 guidance papers on gouts shows agreement over T2T fo ruric acid level and long-term controlindications for urate-lowering therapy 1st line drugs acute attack. Inconsistent were the initiation of ULT & Rx of asymptomatic hyperuricemia.
11 Sep 2019 Social UK Clinical Practice Database compared 68,897 gout pts vs 554,964 without gout, showing gout doubles risk of (8.5/1000PY vs 4.1/1000PY w/o gout). Risk highest with ESRD. Gout did not increase CKD related deaths.
05 Sep 2019 News Modifiable Risk Factors for Hyperuricemia
20 Aug 2019 Social 87 #Gout patients treated with ULT and followed with serial Xrays and DECT scanning shows that lowering uric acid in a T2T strategy did not change xray over 2 years, but did show significantly less urate erosions by DECT.
14 Aug 2019 Social Cross sectional analysis of ~3000 and meta-analysis (14 studies) finds #gout has a higher risk of hypothyroidism, esp in female gout pts (OR=2.44;1.15-5.17); Metaanalysis ^risk hypothyroidism in gout (OR=1.51) and hyperuricemic pts (OR=1.34)
08 Aug 2019 Social Internet based study by Choi et al - looked at 517 gout patients and examined if gout flares were associated with vaccination. They found a twofold higher odds of gout flare (adjusted OR 1.99; 95% CI 1.01 to 3.89 in those who were vaccinated (any vaccine).
07 Aug 2019 Social Prospective study of 83 gout patients; 77 on urate lowering Rx, 6 discontinued Rx. The D/C group had no change in MSU deposits or SUA levels, In the ULT group MSU burden significantly decreased (MSU volume: p=0.007) and sUA dropped from 7.2 to 5,8 mg/dl.
07 Aug 2019 Social PLoS reports that a study of 10,059 men from Israel were followed serially showing that higher variability in serum Uric Acid levels over 5 years was clearly predictive of 18-year Coronary heart disease and all-cause mortality.
02 Aug 2019 Social 70 #gout pts studied & 44.3% developed post-surgical flares. Risk factors included Presurgical sUA ≥ 9 mg/dL (OR 3.77) & sUA changes before and after surgery (OR 1.62); but \allopurinol reduced risk (OR 0.15). Mean time to flare=3.7 days. Knee > MTP1
31 Jul 2019 Social Observational study of 124 gouty patients with high cholesterol & triglycerides treated with ULT (febuxostat, allopurinol, benzbromarone) showed that ULT significantly lowered SUA and lipid levels too.
31 Jul 2019 Social NHANES analysis shows that higher serum uric acid (SUA) levels had a greater risk of coronary heart disease and stroke mortality (mainly women >50 years); but there was no link between SUA and all-cause and cancer mortality.