Friday, 18 Oct 2019


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16 May 2019 Social Medicare analysis shows Gout patients are twice as likely to have chronic pain (HR 2.02; 95% CI 1.98-2.05) and use of allopurinol or febuxostat was associated with a lower risk of chronic pain (HR 0.72-0.79)
26 Apr 2016 Social Astra-Zeneca sells the rights to sell gout drug Zurampic (lesinurad) to Ironwood pharmaceutical for $265 million.
10 Jun 2015 Social Efficacy of Anakinra in Crystal synovitis. Complete improvement is seen in 3-5 days
07 Nov 2017 Social RT @KDAO2011: Prior allopurinol use may reduce risk for NSAID induce acute kidney injury in gout pts #141 #ACR17 @rheumnow…
07 Aug 2018 Social 10 yr study of ~13k US VA gout pts who did/didnt increase allopurinol shows dose escalation seldom achieved target SUA <6.0, but was associated with increased mortality (HR 1.08; 95%CI 1.01–1.17). Escalation more a marker of severity, not T2T
11 Jun 2016 Social 1,280 gout compared to 1,231 OA pts; gout had more CVD risk factors, hypertension, ^lipids, CKD but not more MI.
01 Dec 2016 Social Takeda 2 yr study of 314 early #gout pts showed less acute flares w/ Uloric vs PBO (29% v 41%), but not in 1st 6mos.
04 Mar 2018 Social RheumNow Wk in Review is up. Cool stuff on FDG PET in Lg Vessel vasculitis, gout Rx, nutraceuticals in OA. Listen here ht tps:// or watch it on website
17 Aug 2015 Social Salivery uric acid levels measureable in gout - more proof that gout is a systemic uric acid deposition disease
07 Aug 2019 Social Prospective study of 83 gout patients; 77 on urate lowering Rx, 6 discontinued Rx. The D/C group had no change in MSU deposits or SUA levels, In the ULT group MSU burden significantly decreased (MSU volume: p=0.007) and sUA dropped from 7.2 to 5,8 mg/dl.
15 Mar 2017 Social Xrays & DECT in 92 gout pts, tophi and urate assoc w/ 80% of all erosions. Urate, tophus volume predict erosions
22 Sep 2016 Social #Gout & anti-HTN meds: diuretics, ꞵ-blockers, α-1 blockers signif increase uric acid levels. No effect w/ CCB, ACEI
16 May 2017 Social Drug induced hyperuricemia: Diuretics, EMB, PZA, ASA, CyA, fructose, nicotinic acid, Xylitol, lactate, cytotoxics
26 Oct 2015 Social 75 pts >50 yrs w knee effusions were studied:Ultrasound was more sensitive(60 v 40%) & specific (97 v 83%) than Xray
27 Oct 2017 Social RheumNow Wk in Review is up! Cush on gout, CV risk, Biosimilars,FDA approvals.Vid or podcast
16 Mar 2016 Social In a 6 mos RCT, Febuxostat slows the decline in GFR in CKD stages 3/4 compared to placebo.
09 May 2015 Social Review of Losartan shows its uricosuric, can lower Uric acid ~1.6 mg/dl & may be useful in HTN w/ hyperuricemia
06 Nov 2017 Social RT @Janetbirdope: #GAMECHANGERS If you have gout and typeII diabetes you have worse gout. More tophi and erosions. #acr17 @rheumnow #1118…
06 Jun 2019 Social The overall prevalence of gout among US adults is 3.9%, affecting 9.2 million people. Hyperuricaemia prevalence is 14.6% - affecting 32.5 million in the US. Data from NHANES NHANES 2015–16
10 May 2016 Social Population (34K) based Taiwan study shows gout assoc w/ higher risk of depression; that is normalized w/ pred or ULT