Friday, 18 Oct 2019

Gout/Crystal

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08 Aug 2019 Social Internet based study by Choi et al - looked at 517 gout patients and examined if gout flares were associated with vaccination. They found a twofold higher odds of gout flare (adjusted OR 1.99; 95% CI 1.01 to 3.89 in those who were vaccinated (any vaccine). https://t.co/8zLSt3YVZF
27 Apr 2016 Social Erosive polyarthritis a RARE presentation of hydroxyapatite deposition Dz. More common is calcific periarthritis https://t.co/FosL2jRnN4
22 Feb 2019 Social FDAhas added a boxed warning to the label for gout drug febuxostat (Uloric) based on results of a large postmarketing safety study and AAC panel Recs. FDA concluded that there is an increased risk for death with febuxostat compared allopurinol https://t.co/v1ANA3lI0g
23 Mar 2017 Social 3 US features of GOUT: double contour sign, tophus (hyperechoic aggregates), “snowstorm” of MSU aggregates https://t.co/ragnHxBTRW
19 Jun 2018 Social Using medicare claims data, Singh & Cleveland show that elderly >65 yrs gout pts have a risk of MI = 4.1 per 1000 PYs and is 2 fold higher than those without gout. https://t.co/jozY7tc40r
14 Jun 2016 Social Tophaceous gout occurs after >10yrs & found on ear helix, fingers, toes, wrists knees, olecranon Achilles & sclera https://t.co/6BlVuEgM89
14 May 2018 Social UAB to lead the RECIPE trial in gout - a phase II trial to evaluate the utility of background mycophenolate (MMF) in patient receiving IV pegloticase injection for gout. Presumeably the MMF will block any interferring immunogenicity to PEG. https://t.co/ypBjwkeLpf
05 Mar 2019 Social An Internet survey of 320 physician-diagnosed #gout pts finds that 23% diagnosed as having a sleep disorder (sleep apnea, 17%). Their mean sleep time was 6.7 h per night; 86% reported snoring during sleep and 2/3 reported feeling sleepy during the day https://t.co/7DiuZOM1aw
31 Aug 2017 Social RT @pg_saavedra: Acute #gout treatment algorithm by Mayo Clinics #GoutFlare #AcuteGout @RheumPearls @RheumNow @ACRheum @RheumJnl https://t.…
31 Aug 2016 Social Canadian data same as US; #RA hosp. cut in half while #Gout hospitalizations have doubled https://t.co/qVnEAvN538 https://t.co/KFOpKxEPd3
16 Jun 2018 Social RT @DrPetryna: #eular18 @RheumNow ABST sat0357 only 51.7% of pts compliant with ULT ( allopurinol&uloric predominantly) after 1 year. The m…
06 Nov 2017 Social RT @philipcrobinson: Many many gout patients who are uncontrolled in the US. Need to get them on Rx #ACR17 #168 @RheumNow https://t.co/MOY3…
06 Nov 2017 Social RT @DrRachelTate: How do you approach your hyperuricemia pts? #ACR17 @RheumNow
07 Dec 2017 Social Systematic review of ULT discontinuation - 5 studies shows that ULT D/C has good short term outcomes (esp if SUA is low) but delayed relapse rates occcuring 1-4.5 yrs later - more in gout (36-81%), less w/ urolithiasis (15%). https://t.co/RTIwuH154S
13 May 2015 Social NonAlcoholic fatty liver dz signif lower w/ regular low dose ASA; but higher w/ hyperuricemia http://t.co/8tS9dAkmuA http://t.co/Jod0578pcw
16 Jul 2019 Social ER study from 2015-17 shows that among 456 #gout patients, 28.3%) received opioid at discharge; 80% of these were new. Average dose was 38mg morphine equivalent for a median of 8 days - more likely w/ polyarticular gout, hx diabetes & hx prior opioids https://t.co/xf2jD1i4hg
03 Jan 2019 Social Analysis of pegloticase clinical trial data shows that tophus resolution was achieved by 69.6% of 23 responders, 27.9% of 43 nonresponders, and 14.3% of 21 patients who received placebo. Resolution time = 9.9 mos. https://t.co/4Pu16t3BV8
13 Feb 2018 Social Systematic review of DECT Scanning in Gout included 32 articles & 1502 pts. DECT takes little time and has low radiation exposure but limited availability. It showed Sensitivity & Specificity > 80%. Dx performance was better than Xray, CT, equal to US https://t.co/GkbSKNP7D2
17 May 2016 Social Gout prevalencein NIDDM is ~10%; Those w/ both likely to be elderly, men, obese, high lipids, neuropathy w/ Low GFR https://t.co/FWnneUXn11
31 Mar 2018 Social RT @Rheuma_suffolk: @RonanTKavanagh @psufka @Dr_BoAbrahamsen Just reading on #gout and found this gem of a paragraph about good practice in…