Friday, 15 Nov 2019

Gout/Crystal

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02 Oct 2015 Social Cactus Registry of 3079 #Gout pts, more than 1/2 have obesity, HTN, Hi-Lipids. Mean entry urate = 8.7 mg/dl http://t.co/XVx11sqIG5
07 Dec 2017 Social Systematic review of ULT discontinuation - 5 studies shows that ULT D/C has good short term outcomes (esp if SUA is low) but delayed relapse rates occcuring 1-4.5 yrs later - more in gout (36-81%), less w/ urolithiasis (15%). https://t.co/RTIwuH154S
27 Jul 2016 Social Quercetin shown to signif. reduce Uric acid, it inhibits xanthine oxidoreductase in vitro. Not studied in gout. https://t.co/0Fq95UK3PS
04 Nov 2017 Social RT @DrPetryna: FORTUNE1: stepwise ⬆️ of Uloric dose comparable to colchicine+Uloric in flare prevention during intro Rx https://t.co/MifSt…
27 Oct 2015 Social Study of 97 pts: Risk of anaphylaxis with 1st infusion of rasburicase is zero, but goes to 6.1% with 2nd infusion. https://t.co/GAnejQK2Ja
13 Feb 2018 Social Systematic review of DECT Scanning in Gout included 32 articles & 1502 pts. DECT takes little time and has low radiation exposure but limited availability. It showed Sensitivity & Specificity > 80%. Dx performance was better than Xray, CT, equal to US https://t.co/GkbSKNP7D2
05 Oct 2016 Social Systematic review of gout shows that allopurinol Rx significantly lowers systolic & diastolic BP & creatinine levels https://t.co/F1LbrU1UUA
06 Nov 2017 Social RT @DrRachelTate: How do you approach your hyperuricemia pts? #ACR17 @RheumNow
03 Jan 2019 Social Analysis of pegloticase clinical trial data shows that tophus resolution was achieved by 69.6% of 23 responders, 27.9% of 43 nonresponders, and 14.3% of 21 patients who received placebo. Resolution time = 9.9 mos. https://t.co/4Pu16t3BV8
26 Apr 2018 Social A large CV prevention trial found 722 new gout cases among 12,866 men (age 35–57). Chronic kidney dz assoc w/ a 61% incr risk of gout (HR 1.61), increased w/ proteinuria & hematuria, but not by serum urate https://t.co/DOUBaACaM6
10 Jun 2015 Social The relationship between urate, allopurinol & CV events & renal disease reviewed Am J Kid Dz http://t.co/vN1hKzLtO5
21 Apr 2016 Social Gout on urate lowering Rx who get attacks are: 1) noncompliant; 2) not on right dose; 3) havent reached target <6; 4) new renal dysfunction
14 Mar 2017 Social Great review of Gout 2017 by Dr. Keenan. Gout care cost $31.8 billion from 2005-11 https://t.co/hq8zGLNzUw
02 Aug 2018 Social Olmstead county study of 429 gout patients shows that hospitalization was associated with a 10 fold increase risk of gout flares & in hosp gout flares prolonged hospitalization by avg of 1.8 days. (all highly significant) https://t.co/ICyq4RzCds
16 Jun 2018 Social RT @RonanTKavanagh: Vazquez-Mellado. Mexican patients with severe gout tend to be younger age at onset, lower educational level and socioec…
12 Aug 2015 Social In CKD patients allopurinol adjustments may not be needed; but Colchicine must be adjusted w/ CKD- high toxicity risk http://t.co/ZsfwuCXxwv
18 Aug 2017 Social Study of Acute gout: 26% had SF MSU & CPP crystals. CPP crystals assoc w/ gout duration, CKD, erosive dz; not age https://t.co/K8OT8yanNW
28 Sep 2018 Social Horizon announces a new trial to evaluate the efficacy of MTX in prolonging efficacy and preventing anti-PEG antibodies in refractory gout patients treated with Pegloticase IV https://t.co/x47QSzwdmO
07 Aug 2019 Social PLoS reports that a study of 10,059 men from Israel were followed serially showing that higher variability in serum Uric Acid levels over 5 years was clearly predictive of 18-year Coronary heart disease and all-cause mortality. https://t.co/bDqI32aVXt
28 Aug 2016 Social Gout patients have a 17% increased risk of fractures ( limbs & spine). Interestingly allopurinol use lowers risk https://t.co/aPKeAQTy0w