Thursday, 21 Nov 2019


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04 Nov 2017 Social RT @DrPetryna: FORTUNE1: stepwise ⬆️ of Uloric dose comparable to colchicine+Uloric in flare prevention during intro Rx…
16 Jul 2019 Social ER study from 2015-17 shows that among 456 #gout patients, 28.3%) received opioid at discharge; 80% of these were new. Average dose was 38mg morphine equivalent for a median of 8 days - more likely w/ polyarticular gout, hx diabetes & hx prior opioids
03 Jan 2019 Social Analysis of pegloticase clinical trial data shows that tophus resolution was achieved by 69.6% of 23 responders, 27.9% of 43 nonresponders, and 14.3% of 21 patients who received placebo. Resolution time = 9.9 mos.
27 Oct 2015 Social Study of 97 pts: Risk of anaphylaxis with 1st infusion of rasburicase is zero, but goes to 6.1% with 2nd infusion.
13 Feb 2018 Social Systematic review of DECT Scanning in Gout included 32 articles & 1502 pts. DECT takes little time and has low radiation exposure but limited availability. It showed Sensitivity & Specificity > 80%. Dx performance was better than Xray, CT, equal to US
17 May 2016 Social Gout prevalencein NIDDM is ~10%; Those w/ both likely to be elderly, men, obese, high lipids, neuropathy w/ Low GFR
06 Nov 2017 Social RT @DrRachelTate: How do you approach your hyperuricemia pts? #ACR17 @RheumNow
31 Mar 2018 Social RT @Rheuma_suffolk: @RonanTKavanagh @psufka @Dr_BoAbrahamsen Just reading on #gout and found this gem of a paragraph about good practice in…
27 Jul 2016 Social Quercetin shown to signif. reduce Uric acid, it inhibits xanthine oxidoreductase in vitro. Not studied in gout.
13 Jul 2018 Social 5 year analysis of gout descriptors from 549 articles looked at 11 basic Dz elements & 343 unique labels, most being imprecise. An acute attack was represented by 162 unique labels w/ 1/3 articles referring to this element used at least four unique labels
13 May 2015 Social NonAlcoholic fatty liver dz signif lower w/ regular low dose ASA; but higher w/ hyperuricemia
13 Jun 2018 Social Dr Solomons plenary session on CANTOS substudy in @risk CVD pts shows Canakinumab lowered the risk of acute gout attacks by 50-60%, lowered hsCRP but not SUA levels. #EULAR2018 @RheumNow OP0014
05 Oct 2016 Social Systematic review of gout shows that allopurinol Rx significantly lowers systolic & diastolic BP & creatinine levels
12 Apr 2019 Social 71-80% of primary care diagnosed gout patients meet criteria for a gout diagnosis.
30 May 2017 Social British Soc.Rheumatology releases new guideline for Rx of gout; noting curative ULT must be offered to all pts early
02 Oct 2015 Social Cactus Registry of 3079 #Gout pts, more than 1/2 have obesity, HTN, Hi-Lipids. Mean entry urate = 8.7 mg/dl
07 Dec 2017 Social Systematic review of ULT discontinuation - 5 studies shows that ULT D/C has good short term outcomes (esp if SUA is low) but delayed relapse rates occcuring 1-4.5 yrs later - more in gout (36-81%), less w/ urolithiasis (15%).
21 Apr 2016 Social Gout on urate lowering Rx who get attacks are: 1) noncompliant; 2) not on right dose; 3) havent reached target <6; 4) new renal dysfunction
06 Nov 2017 Social RT @KDAO2011: Gout pts more likely to achieve sUA goal< 6 mg/dL if managed by a rheumatologist. Go team Rheum! #ACR17 #166 @rheumnow https:…
07 Aug 2019 Social PLoS reports that a study of 10,059 men from Israel were followed serially showing that higher variability in serum Uric Acid levels over 5 years was clearly predictive of 18-year Coronary heart disease and all-cause mortality.